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Biology and Biochemistry

D-Index
75
Citations
21767
World Ranking
5277
National Ranking
2508

Overview

Wen Xie is affiliated with the University of Pittsburgh in the United States and has a significant body of research published primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans a range of subfields including Molecular Biology, Pharmacology, Epidemiology, Immunology, and Hepatology.

The scientist's research topics cover diverse areas related to disease mechanisms, drug metabolism, and hormonal regulation. Key topics include:

  • Liver Disease Diagnosis and Treatment
  • Pharmacogenetics and Drug Metabolism
  • Hormonal Regulation and Hypertension
  • Drug Transport and Resistance Mechanisms
  • Estrogen and related hormone effects
  • Drug-Induced Hepatotoxicity and Protection
  • Adipose Tissue and Metabolism

Wen Xie has collaborated frequently with several researchers over the years, including Meishu Xu, Da Yang, Xiaochao Ma, Xinran Cai, and Songrong Ren. These collaborations reflect strong research partnerships contributing to their extensive publication record.

Their published work appears in a variety of journals, with repeated contributions to:

  • Acta Pharmaceutica Sinica B
  • SSRN Electronic Journal
  • The FASEB Journal
  • Science Advances
  • Drug Metabolism and Disposition

Some notable recent papers include:

  • "AI in small-molecule drug discovery: a coming wave?" (2022) in Nature Reviews Drug Discovery
  • "Sirt6 Alleviated Liver Fibrosis by Deacetylating Conserved Lysine 54 on Smad2 in Hepatic Stellate Cells" (2020) in Hepatology
  • "Smart Health" (2022) in Journal of Organizational and End User Computing
  • "The landscape for lipid-nanoparticle-based genomic medicines" (2023) in Nature Reviews Drug Discovery
  • "Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis" (2021) in Gastroenterology

The collected work of Wen Xie reflects an ongoing focus on liver-related diseases, drug metabolism, and molecular biology with a multidisciplinary approach intersecting medicine, pharmacology, and epidemiology.

Best Publications

  • Vitamin D Receptor As an Intestinal Bile Acid Sensor

    Makoto Makishima;Timothy T. Lu;Wen Xie;G. Kerr Whitfield

  • An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

    Wen Xie;Anna Radominska-Pandya;Yanhong Shi;Cynthia M. Simon

  • Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase.

    Hongwu Chen;Richard J Lin;Richard J Lin;Wen Xie;Damien Wilpitz

  • Humanized xenobiotic response in mice expressing nuclear receptor SXR.

    Wen Xie;Joyce L. Barwick;Michael Downes;Bruce Blumberg

  • Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR

    Wen Xie;Joyce L. Barwick;Cynthia M. Simon;Alexis M. Pierce

  • Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

    Jie Zhou;Maria Febbraio;Taira Wada;Yonggong Zhai

  • lncRNA epigenetic landscape analysis identifies EPIC1 as an oncogenic lncRNA that interacts with MYC and promotes cell-cycle progression in cancer

    Zehua Wang;Bo Yang;Min Zhang;Weiwei Guo

  • Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

    Wen Xie;Mei-Fei Yeuh;Anna Radominska-Pandya;Simrat P. S. Saini

  • A Novel Pregnane X Receptor-mediated and Sterol Regulatory Element-binding Protein-independent Lipogenic Pathway

    Jie Zhou;Yonggong Zhai;Ying Mu;Haibiao Gong

  • Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents.

    Xinsheng Gu;Sui Ke;Duan Liu;Tao Sheng

  • ERRγ Directs and Maintains the Transition to Oxidative Metabolism in the Postnatal Heart

    William A. Alaynick;Richard P. Kondo;Wen Xie;Weimin He

  • Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR)

    Junichiro Sonoda;Wen Xie;John M. Rosenfeld;Joyce L. Barwick

  • Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

    Clifford R. Elcombe;Richard C. Peffer;Douglas C. Wolf;Jason Bailey

  • Orphan nuclear receptors: the exotics of xenobiotics.

    Wen Xie;Ronald M. Evans

  • A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification.

    Simrat P. S. Saini;Junichiro Sonoda;Li Xu;David Toma

  • PXR and CAR in energy metabolism.

    Taira Wada;Jie Gao;Wen Xie

  • A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis.

    Jung Hoon Lee;Taira Wada;Maria Febbraio;Jinhan He

  • The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity.

    Jie Gao;Jinhan He;Yonggong Zhai;Taira Wada

  • Nuclear Receptor PXR, transcriptional circuits and metabolic relevance

    Chibueze A. Ihunnah;Mengxi Jiang;Wen Xie

  • Unique forms of human and mouse nuclear receptor corepressor SMRT.

    Peter Ordentlich;Michael Downes;Wen Xie;Anna Genin

Frequent Co-Authors

Song Li
Song Li University of Pittsburgh
Ronald M. Evans
Ronald M. Evans Salk Institute for Biological Studies
Jie Fan
Jie Fan University of Pittsburgh
Raman Venkataramanan
Raman Venkataramanan University of Pittsburgh
Timothy R. Billiar
Timothy R. Billiar University of Pittsburgh
Su Zeng
Su Zeng Zhejiang University
Bruce R. Pitt
Bruce R. Pitt University of Pittsburgh
Youhua Liu
Youhua Liu University of Pittsburgh
Frank J. Gonzalez
Frank J. Gonzalez National Institutes of Health
Bruce Blumberg
Bruce Blumberg University of California, Irvine

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