World's Best Scientists 2026 revealed!
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Wen Xie

D-Index & Metrics

Biology and Biochemistry

D-Index
75
Citations
21767
World Ranking
5277
National Ranking
2508

Wen Xie publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Wen Xie sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 234 publications — 62nd percentile

62% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Wen Xie D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Wen Xie sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 75 D-Index — 74th percentile

74% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Wen Xie is affiliated with the University of Pittsburgh in the United States and has a significant body of research published primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans a range of subfields including Molecular Biology, Pharmacology, Epidemiology, Immunology, and Hepatology.

The scientist's research topics cover diverse areas related to disease mechanisms, drug metabolism, and hormonal regulation. Key topics include:

  • Liver Disease Diagnosis and Treatment
  • Pharmacogenetics and Drug Metabolism
  • Hormonal Regulation and Hypertension
  • Drug Transport and Resistance Mechanisms
  • Estrogen and related hormone effects
  • Drug-Induced Hepatotoxicity and Protection
  • Adipose Tissue and Metabolism

Wen Xie has collaborated frequently with several researchers over the years, including Meishu Xu, Da Yang, Xiaochao Ma, Xinran Cai, and Songrong Ren. These collaborations reflect strong research partnerships contributing to their extensive publication record.

Their published work appears in a variety of journals, with repeated contributions to:

  • Acta Pharmaceutica Sinica B
  • SSRN Electronic Journal
  • The FASEB Journal
  • Science Advances
  • Drug Metabolism and Disposition

Some notable recent papers include:

  • "AI in small-molecule drug discovery: a coming wave?" (2022) in Nature Reviews Drug Discovery
  • "Sirt6 Alleviated Liver Fibrosis by Deacetylating Conserved Lysine 54 on Smad2 in Hepatic Stellate Cells" (2020) in Hepatology
  • "Smart Health" (2022) in Journal of Organizational and End User Computing
  • "The landscape for lipid-nanoparticle-based genomic medicines" (2023) in Nature Reviews Drug Discovery
  • "Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis" (2021) in Gastroenterology

The collected work of Wen Xie reflects an ongoing focus on liver-related diseases, drug metabolism, and molecular biology with a multidisciplinary approach intersecting medicine, pharmacology, and epidemiology.

Best Publications

  • Vitamin D Receptor As an Intestinal Bile Acid Sensor

    Makoto Makishima;Timothy T. Lu;Wen Xie;G. Kerr Whitfield

  • An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

    Wen Xie;Anna Radominska-Pandya;Yanhong Shi;Cynthia M. Simon

  • Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase.

    Hongwu Chen;Richard J Lin;Richard J Lin;Wen Xie;Damien Wilpitz

  • Humanized xenobiotic response in mice expressing nuclear receptor SXR.

    Wen Xie;Joyce L. Barwick;Michael Downes;Bruce Blumberg

  • Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR

    Wen Xie;Joyce L. Barwick;Cynthia M. Simon;Alexis M. Pierce

  • Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

    Jie Zhou;Maria Febbraio;Taira Wada;Yonggong Zhai

  • lncRNA epigenetic landscape analysis identifies EPIC1 as an oncogenic lncRNA that interacts with MYC and promotes cell-cycle progression in cancer

    Zehua Wang;Bo Yang;Min Zhang;Weiwei Guo

  • Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

    Wen Xie;Mei-Fei Yeuh;Anna Radominska-Pandya;Simrat P. S. Saini

  • A Novel Pregnane X Receptor-mediated and Sterol Regulatory Element-binding Protein-independent Lipogenic Pathway

    Jie Zhou;Yonggong Zhai;Ying Mu;Haibiao Gong

  • Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents.

    Xinsheng Gu;Sui Ke;Duan Liu;Tao Sheng

  • ERRγ Directs and Maintains the Transition to Oxidative Metabolism in the Postnatal Heart

    William A. Alaynick;Richard P. Kondo;Wen Xie;Weimin He

  • Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR)

    Junichiro Sonoda;Wen Xie;John M. Rosenfeld;Joyce L. Barwick

  • Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

    Clifford R. Elcombe;Richard C. Peffer;Douglas C. Wolf;Jason Bailey

  • Orphan nuclear receptors: the exotics of xenobiotics.

    Wen Xie;Ronald M. Evans

  • A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification.

    Simrat P. S. Saini;Junichiro Sonoda;Li Xu;David Toma

  • PXR and CAR in energy metabolism.

    Taira Wada;Jie Gao;Wen Xie

  • A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis.

    Jung Hoon Lee;Taira Wada;Maria Febbraio;Jinhan He

  • The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity.

    Jie Gao;Jinhan He;Yonggong Zhai;Taira Wada

  • Nuclear Receptor PXR, transcriptional circuits and metabolic relevance

    Chibueze A. Ihunnah;Mengxi Jiang;Wen Xie

  • Unique forms of human and mouse nuclear receptor corepressor SMRT.

    Peter Ordentlich;Michael Downes;Wen Xie;Anna Genin

Frequent Co-Authors

Song Li
Song Li University of Pittsburgh
Ronald M. Evans
Ronald M. Evans Salk Institute for Biological Studies
Jie Fan
Jie Fan University of Pittsburgh
Raman Venkataramanan
Raman Venkataramanan University of Pittsburgh
Timothy R. Billiar
Timothy R. Billiar University of Pittsburgh
Su Zeng
Su Zeng Zhejiang University
Bruce R. Pitt
Bruce R. Pitt University of Pittsburgh
Youhua Liu
Youhua Liu University of Pittsburgh
Frank J. Gonzalez
Frank J. Gonzalez National Institutes of Health
Bruce Blumberg
Bruce Blumberg University of California, Irvine

External Links

Personal website of Wen Xie

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Best Scientists Citing Wen Xie

Frank J. Gonzalez

Frank J. Gonzalez

National Institutes of Health

Publications: 83

Ronald M. Evans

Ronald M. Evans

Salk Institute for Biological Studies

Publications: 54

Masahiko Negishi

Masahiko Negishi

National Institutes of Health

Publications: 46

Stefano Fiorucci

Stefano Fiorucci

University of Perugia

Publications: 43

Curtis D. Klaassen

Curtis D. Klaassen

University of Kansas

Publications: 42

Michael Trauner

Michael Trauner

Medical University of Vienna

Publications: 37

David D. Moore

David D. Moore

University of California, Berkeley

Publications: 36

Jean-Marc Pascussi

Jean-Marc Pascussi

University of Montpellier

Publications: 35

Satoshi Inoue

Satoshi Inoue

Saitama Medical University

Publications: 30

Sean Ekins

Sean Ekins

University of Arizona

Publications: 29

Bruce Blumberg

Bruce Blumberg

University of California, Irvine

Publications: 29

Erin G. Schuetz

Erin G. Schuetz

St. Jude Children's Research Hospital

Publications: 27

Bart Staels

Bart Staels

University of Lille

Publications: 27

John Y. L. Chiang

John Y. L. Chiang

Northeast Ohio Medical University

Publications: 26

Konstantin G. Birukov

Konstantin G. Birukov

University of Chicago

Publications: 26

Edward L. LeCluyse

Edward L. LeCluyse

Research Triangle Park Foundation

Publications: 25

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