Masahiko Negishi

Overview

Best Publications

• THE NUCLEAR ORPHAN RECEPTOR CAR-RETINOID X RECEPTOR HETERODIMER ACTIVATES THE PHENOBARBITAL-RESPONSIVE ENHANCER MODULE OF THE CYP2B GENE

  Paavo Honkakoski;Igor Zelko;Tatsuya Sueyoshi;Masahiko Negishi

  885
  Citations

• The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene.

  Tatsuya Sueyoshi;Takeshi Kawamoto;Igor Zelko;Paavo Honkakoski

  825
  Citations

• Phenobarbital-Responsive Nuclear Translocation of the Receptor CAR in Induction of the CYP2B Gene

  Takeshi Kawamoto;Tatsuya Sueyoshi;Igor Zelko;Rick Moore

  783
  Citations

• Regulation of cytochrome P450 (CYP) genes by nuclear receptors

  Paavo Honkakoski;Masahiko Negishi

  629
  Citations

• CAR and PXR: the xenobiotic-sensing receptors.

  Yoav E. Timsit;Masahiko Negishi

  566
  Citations

• Diverse Roles of the Nuclear Orphan Receptor CAR in Regulating Hepatic Genes in Response to Phenobarbital

  Akiko Ueda;Hisham K. Hamadeh;Heather K. Webb;Yukio Yamamoto

  549
  Citations

• Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.

  Raija L. P. Lindberg;Masahiko Negishi

  546
  Citations

• The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

  Junko Sugatani;Hiroyuki Kojima;Akiko Ueda;Satoru Kakizaki

  531
  Citations

• Structure and function of sulfotransferases.

  Masahiko Negishi;Lee G. Pedersen;Lee G. Pedersen;Evgeniy Petrotchenko;Sergei Shevtsov

  437
  Citations

• Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes

  Susumu Kodama;Chika Koike;Masahiko Negishi;Yukio Yamamoto

  396
  Citations

• The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice.

  Yukio Yamamoto;Rick Moore;Thomas L. Goldsworthy;Masahiko Negishi

  387
  Citations

• Genetic Mechanisms Controlling the Induction of Polysubstrate Monooxygenase (P-450) Activities

  D. W. Nebert;H. J. Eisen;M. Negishi;M. A. Lang

  377
  Citations

• Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus

  Shuanfang Li;Kimberly A. Washburn;Rick Moore;Tomohide Uno

  368
  Citations

• Crystal structure of estrogen sulphotransferase

  Yoshimitsu Kakuta;Lee G. Pedersen;Charles W. Carter;Masahiko Negishi

  366
  Citations

• Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity.

  Grace L. Guo;Gilles Lambert;Masahiko Negishi;Jerrold M. Ward

  351
  Citations

• Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers

  Stephanie R. Faucette;Tong Cun Zhang;Rick Moore;Tatsuya Sueyoshi

  334
  Citations

• Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia.

  Junko Sugatani;Kasumi Yamakawa;Kouich Yoshinari;Takashi Machida

  286
  Citations

• Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor.

  Yuping Chen;Stephen S. Ferguson;Masahiko Negishi;Joyce A. Goldstein

  275
  Citations

• Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I.

  Lars C. Pedersen;Kazunori Tsuchida;Hiroshi Kitagawa;Kazuyuki Sugahara

  266
  Citations

• Synthesis and insertion of cytochrome P-450 into endoplasmic reticulum membranes.

  Shoshana Bar-Nun;Gert Kreibich;Milton Adesnik;Lon Alterman

  255
  Citations