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D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
13754
World Ranking
8788
National Ranking
673

Overview

Brian G. Lake is affiliated with the University of Surrey in the United Kingdom. Their research spans multiple fields including Biochemistry, Genetics and Molecular Biology; Medicine; and Pharmacology, Toxicology and Pharmaceutics. Within these, the subfields of Pharmacology, Plant Science, Biochemistry, Molecular Biology, and Endocrinology, Diabetes and Metabolism are prominent in their work.

Research topics covered by Brian G. Lake include:

  • Pharmacogenetics and Drug Metabolism
  • Pesticide Exposure and Toxicity
  • Eicosanoids and Hypertension Pharmacology
  • Peroxisome Proliferator-Activated Receptors
  • Inflammatory mediators and NSAID effects
  • Growth Hormone and Insulin-like Growth Factors
  • Drug Transport and Resistance Mechanisms

Some of the recent papers authored or co-authored by Brian G. Lake are:

  • "Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)," 2021, published in Critical Reviews in Toxicology
  • "Comparison of the Hepatic Effects of Phenobarbital in Chimeric Mice Containing Either Rat or Human Hepatocytes With Humanized Constitutive Androstane Receptor and Pregnane X Receptor Mice," 2020, published in Toxicological Sciences
  • "An Evaluation of the Human Relevance of the Liver Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action," 2020, published in Toxicological Sciences
  • "Piperonyl butoxide: Mode of action analysis for mouse liver tumour formation and human relevance," 2020, published in Toxicology
  • "Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids," 2020, published in Toxicological Sciences

Frequent co-authors collaborating with Brian G. Lake include:

  • Thomas G. Osimitz
  • Tomoya Yamada
  • Samuel M. Cohen
  • Lynsey R. Chatham
  • Moire R. Creek

The scientist's work has been published predominantly in the following journals:

  • Critical Reviews in Toxicology
  • Toxicological Sciences
  • Toxicology
  • Xenobiotica
  • Regulatory Toxicology and Pharmacology

Best Publications

  • A Cancer Risk Assessment of Di(2-ethylhexyl)phthalate: Application of the New U.S. EPA Risk Assessment Guidelines

    John Doull;Russell Cattley;Cliff Elcombe;Brian G. Lake

  • Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

    Zoe E Barter;Martin K Bayliss;Philip H Beaune;Alan R Boobis

  • Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans

    Russell C. Cattley;John DeLuca;Cliff Elcombe;Penelope Fenner-Crisp

  • Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

    Clifford R. Elcombe;Richard C. Peffer;Douglas C. Wolf;Jason Bailey

  • Studies on the hepatic effects of orally administered di-)2-ethylhexyl) phthalate in the rat.

    B.G. Lake;S.D. Gangolli;P. Grasso;A.G. Lloyd

  • Peroxisome proliferation and nongenotoxic carcinogenesis: Commentary on a symposium

    David E. Moody;Janardan K. Reddy;Brian G. Lake;James A. Popp

  • Peroxisome proliferation in primary cultures of rat hepatocytes

    Tim J.B. Gray;Brian G. Lake;Jenny A. Beamand;John R. Foster

  • Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes.

    Vangala Subrahmanyam;Anthony B. Renwick;David G. Walters;Philip J. Young

  • Microsomal cytochrome P-452 induction and peroxisome proliferation by hypolipidaemic agents in rat liver. A mechanistic inter-relationship.

    Raj Sharma;Brian G. Lake;John Foster;G. Gordon Gibson

  • The in vitro hydrolysis of some phthalate diesters by hepatic and intestinal preparations from various species.

    Brian G. Lake;John C. Phillips;John C. Linnell;Sharat D. Gangolli

  • Induction of drug metabolism: species differences and toxicological relevance.

    Mark J. Graham;Mark J. Graham;Brian G. Lake

  • Comparative studies on nafenopin-induced hepatic peroxisome proliferation in the rat, Syrian hamster, guinea pig, and marmoset.

    Brian G. Lake;John G. Evans;Tim J.B. Gray;Sally A. Körösi

  • The influence of some hepatic enzyme inducers and inhibitors on extrahepatic drug metabolism.

    Brian G. Lake;Robert Hopkins;Jagadish Chakraborty;James W. Bridges

  • Studies on the mechanism of coumarin-induced toxicity in rat hepatocytes: comparison with dihydrocoumarin and other coumarin metabolites.

    Brian G. Lake;Tim J.B. Gray;John G. Evans;David F.V. Lewis

  • Peroxisome proliferation in cultured rat hepatocytes produced by clofibrate and phthalate ester metabolites

    T.J.B. Gray;J.A. Beamand;B.G. Lake;J.R. Foster

  • Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans

    David G. Walters;Philip J. Young;Cynthia Agus;Mark G. Knize

  • Comparative studies on di-(2-ethylhexyl) phthalate-induced hepatic peroxisome proliferation in the rat and hamster.

    Brian G. Lake;Tim J.B. Gray;John R. Foster;Colin R. Stubberfield

  • Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man.

    Stephen Murray;Brian G. Lake;Stuart Gray;Anne J. Edwards

  • Induction of cytochrome P-450-dependent enzyme activities in cultured rat liver slices

    B.G. Lake;J.A. Beamand;A.C. Japenga;A. Renwick

  • Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices

    A.B. Renwick;P.S. Watts;R.J. Edwards;P.T. Barton

Frequent Co-Authors

David F.V. Lewis
David F.V. Lewis University of Surrey
Samuel Monroe Cohen
Samuel Monroe Cohen University of Nebraska Medical Center
Alan R. Boobis
Alan R. Boobis Imperial College London
Costas Ioannides
Costas Ioannides University of Surrey
Robert J. Turesky
Robert J. Turesky University of Minnesota
Olavi Pelkonen
Olavi Pelkonen University of Oulu
José V. Castell
José V. Castell University of Valencia
Magnus Ingelman-Sundberg
Magnus Ingelman-Sundberg Karolinska Institute
Ronald N. Hines
Ronald N. Hines Yale University
J. Brian Houston
J. Brian Houston University of Manchester

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