What is he best known for?
The fields of study he is best known for:
His primary areas of investigation include Biochemistry, Peroxisome, Endocrinology, Internal medicine and Cytochrome P450.
His Biochemistry study frequently draws connections to adjacent fields such as Cruciferous vegetables.
His work on Peroxisome Proliferation and Nafenopin as part of his general Peroxisome study is frequently connected to Carnitine O-acetyltransferase, thereby bridging the divide between different branches of science.
His Endocrinology research is multidisciplinary, incorporating perspectives in Receptor, Ciprofibrate, Phthalate and Toxicity.
His research in Cytochrome P450 intersects with topics in Microsome, Isozyme and Pharmacology.
His Microsome research is multidisciplinary, relying on both Enzyme inducer and Hydroxylation.
His most cited work include:
- Scaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance From In Vitro Data: Reaching a Consensus on Values of Human Micro-somal Protein and Hepatocellularity Per Gram of Liver (321 citations)
- A Cancer Risk Assessment of Di(2-ethylhexyl)phthalate: Application of the New U.S. EPA Risk Assessment Guidelines (270 citations)
- Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic Hazard to Humans (228 citations)
What are the main themes of his work throughout his whole career to date?
Brian G. Lake mainly focuses on Biochemistry, Endocrinology, Internal medicine, Cytochrome P450 and Microsome.
As part of his studies on Biochemistry, he often connects relevant areas like Toxicity.
His Endocrinology study combines topics from a wide range of disciplines, such as Peroxisome, Phthalate, Peroxisome Proliferation and Hepatocyte.
His studies in Internal medicine integrate themes in fields like Mechanism of action and Carcinogen.
His Cytochrome P450 research is multidisciplinary, incorporating elements of Isozyme and Enzyme inducer.
His Microsome study combines topics in areas such as Cytochrome, Oxidase test and Hydroxylation.
He most often published in these fields:
- Biochemistry (46.83%)
- Endocrinology (32.94%)
- Internal medicine (32.94%)
What were the highlights of his more recent work (between 2010-2021)?
- Constitutive androstane receptor (7.14%)
- Cytochrome P450 (27.78%)
- Internal medicine (32.94%)
In recent papers he was focusing on the following fields of study:
Brian G. Lake mostly deals with Constitutive androstane receptor, Cytochrome P450, Internal medicine, Endocrinology and Hepatocyte.
Cytochrome P450 is a subfield of Biochemistry that Brian G. Lake investigates.
The concepts of his Biochemistry study are interwoven with issues in Cruciferous vegetables and 1h nmr spectroscopy.
His Internal medicine study incorporates themes from Cancer research and Permethrin.
His Permethrin research is multidisciplinary, incorporating elements of Adenoma, Cis–trans isomerism, Microsome, Programmed cell death and Metabolism.
His studies in Hepatocyte integrate themes in fields like Liver tumor and Phenobarbital.
Between 2010 and 2021, his most popular works were:
- Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator (164 citations)
- Identification of human urinary biomarkers of cruciferous vegetable consumption by metabonomic profiling. (83 citations)
- Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an In Vivo Study Using a Chimeric Mouse with Humanized Liver (44 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Gene
- Internal medicine
His primary scientific interests are in Constitutive androstane receptor, Pharmacology, DNA synthesis, Carcinogen and Cytochrome P450.
Brian G. Lake has included themes like Mouse bioassay, Cancer and Bioinformatics in his Pharmacology study.
He combines subjects such as Lung, Hyperplasia and Genotoxicity with his study of Carcinogen.
His Cytochrome P450 study is concerned with Metabolism in general.
As a part of the same scientific family, Brian G. Lake mostly works in the field of Hepatocyte, focusing on Cell growth and, on occasion, Endocrinology, Internal medicine, Permethrin, Adenoma and Programmed cell death.
His work on Endocrinology is being expanded to include thematically relevant topics such as Pharmacokinetics.
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