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Brian G. Lake

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
13754
World Ranking
8788
National Ranking
673

Brian G. Lake publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Brian G. Lake sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 298 publications — 78th percentile

78% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Brian G. Lake D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Brian G. Lake sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 66 D-Index — 57th percentile

57% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Brian G. Lake is affiliated with the University of Surrey in the United Kingdom. Their research spans multiple fields including Biochemistry, Genetics and Molecular Biology; Medicine; and Pharmacology, Toxicology and Pharmaceutics. Within these, the subfields of Pharmacology, Plant Science, Biochemistry, Molecular Biology, and Endocrinology, Diabetes and Metabolism are prominent in their work.

Research topics covered by Brian G. Lake include:

  • Pharmacogenetics and Drug Metabolism
  • Pesticide Exposure and Toxicity
  • Eicosanoids and Hypertension Pharmacology
  • Peroxisome Proliferator-Activated Receptors
  • Inflammatory mediators and NSAID effects
  • Growth Hormone and Insulin-like Growth Factors
  • Drug Transport and Resistance Mechanisms

Some of the recent papers authored or co-authored by Brian G. Lake are:

  • "Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)," 2021, published in Critical Reviews in Toxicology
  • "Comparison of the Hepatic Effects of Phenobarbital in Chimeric Mice Containing Either Rat or Human Hepatocytes With Humanized Constitutive Androstane Receptor and Pregnane X Receptor Mice," 2020, published in Toxicological Sciences
  • "An Evaluation of the Human Relevance of the Liver Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action," 2020, published in Toxicological Sciences
  • "Piperonyl butoxide: Mode of action analysis for mouse liver tumour formation and human relevance," 2020, published in Toxicology
  • "Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids," 2020, published in Toxicological Sciences

Frequent co-authors collaborating with Brian G. Lake include:

  • Thomas G. Osimitz
  • Tomoya Yamada
  • Samuel M. Cohen
  • Lynsey R. Chatham
  • Moire R. Creek

The scientist's work has been published predominantly in the following journals:

  • Critical Reviews in Toxicology
  • Toxicological Sciences
  • Toxicology
  • Xenobiotica
  • Regulatory Toxicology and Pharmacology

Best Publications

  • A Cancer Risk Assessment of Di(2-ethylhexyl)phthalate: Application of the New U.S. EPA Risk Assessment Guidelines

    John Doull;Russell Cattley;Cliff Elcombe;Brian G. Lake

  • Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

    Zoe E Barter;Martin K Bayliss;Philip H Beaune;Alan R Boobis

  • Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans

    Russell C. Cattley;John DeLuca;Cliff Elcombe;Penelope Fenner-Crisp

  • Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

    Clifford R. Elcombe;Richard C. Peffer;Douglas C. Wolf;Jason Bailey

  • Studies on the hepatic effects of orally administered di-)2-ethylhexyl) phthalate in the rat.

    B.G. Lake;S.D. Gangolli;P. Grasso;A.G. Lloyd

  • Peroxisome proliferation and nongenotoxic carcinogenesis: Commentary on a symposium

    David E. Moody;Janardan K. Reddy;Brian G. Lake;James A. Popp

  • Peroxisome proliferation in primary cultures of rat hepatocytes

    Tim J.B. Gray;Brian G. Lake;Jenny A. Beamand;John R. Foster

  • Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes.

    Vangala Subrahmanyam;Anthony B. Renwick;David G. Walters;Philip J. Young

  • Microsomal cytochrome P-452 induction and peroxisome proliferation by hypolipidaemic agents in rat liver. A mechanistic inter-relationship.

    Raj Sharma;Brian G. Lake;John Foster;G. Gordon Gibson

  • The in vitro hydrolysis of some phthalate diesters by hepatic and intestinal preparations from various species.

    Brian G. Lake;John C. Phillips;John C. Linnell;Sharat D. Gangolli

  • Induction of drug metabolism: species differences and toxicological relevance.

    Mark J. Graham;Mark J. Graham;Brian G. Lake

  • Comparative studies on nafenopin-induced hepatic peroxisome proliferation in the rat, Syrian hamster, guinea pig, and marmoset.

    Brian G. Lake;John G. Evans;Tim J.B. Gray;Sally A. Körösi

  • The influence of some hepatic enzyme inducers and inhibitors on extrahepatic drug metabolism.

    Brian G. Lake;Robert Hopkins;Jagadish Chakraborty;James W. Bridges

  • Studies on the mechanism of coumarin-induced toxicity in rat hepatocytes: comparison with dihydrocoumarin and other coumarin metabolites.

    Brian G. Lake;Tim J.B. Gray;John G. Evans;David F.V. Lewis

  • Peroxisome proliferation in cultured rat hepatocytes produced by clofibrate and phthalate ester metabolites

    T.J.B. Gray;J.A. Beamand;B.G. Lake;J.R. Foster

  • Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans

    David G. Walters;Philip J. Young;Cynthia Agus;Mark G. Knize

  • Comparative studies on di-(2-ethylhexyl) phthalate-induced hepatic peroxisome proliferation in the rat and hamster.

    Brian G. Lake;Tim J.B. Gray;John R. Foster;Colin R. Stubberfield

  • Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man.

    Stephen Murray;Brian G. Lake;Stuart Gray;Anne J. Edwards

  • Induction of cytochrome P-450-dependent enzyme activities in cultured rat liver slices

    B.G. Lake;J.A. Beamand;A.C. Japenga;A. Renwick

  • Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices

    A.B. Renwick;P.S. Watts;R.J. Edwards;P.T. Barton

Frequent Co-Authors

David F.V. Lewis
David F.V. Lewis University of Surrey
Samuel Monroe Cohen
Samuel Monroe Cohen University of Nebraska Medical Center
Alan R. Boobis
Alan R. Boobis Imperial College London
Costas Ioannides
Costas Ioannides University of Surrey
Robert J. Turesky
Robert J. Turesky University of Minnesota
Olavi Pelkonen
Olavi Pelkonen University of Oulu
José V. Castell
José V. Castell University of Valencia
Magnus Ingelman-Sundberg
Magnus Ingelman-Sundberg Karolinska Institute
Ronald N. Hines
Ronald N. Hines Yale University
J. Brian Houston
J. Brian Houston University of Manchester

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Best Scientists Citing Brian G. Lake

Amin Rostami-Hodjegan

Amin Rostami-Hodjegan

University of Manchester

Publications: 53

David F.V. Lewis

David F.V. Lewis

University of Surrey

Publications: 51

Costas Ioannides

Costas Ioannides

University of Surrey

Publications: 30

Melvin E. Andersen

Melvin E. Andersen

Research Triangle Park Foundation

Publications: 28

Frank J. Gonzalez

Frank J. Gonzalez

National Institutes of Health

Publications: 28

Ivonne M.C.M. Rietjens

Ivonne M.C.M. Rietjens

Wageningen University & Research

Publications: 28

Robert J. Turesky

Robert J. Turesky

University of Minnesota

Publications: 27

J. Brian Houston

J. Brian Houston

University of Manchester

Publications: 25

Janardan K. Reddy

Janardan K. Reddy

Northwestern University

Publications: 25

Rachel F. Tyndale

Rachel F. Tyndale

University of Toronto

Publications: 24

Joseph W. DePierre

Joseph W. DePierre

Stockholm University

Publications: 24

Samuel Monroe Cohen

Samuel Monroe Cohen

University of Nebraska Medical Center

Publications: 21

Geny M. M. Groothuis

Geny M. M. Groothuis

University of Groningen

Publications: 21

Ernest Hodgson

Ernest Hodgson

North Carolina State University

Publications: 21

Olavi Pelkonen

Olavi Pelkonen

University of Oulu

Publications: 20

Jeffrey M. Peters

Jeffrey M. Peters

Pennsylvania State University

Publications: 19

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