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Geny M. M. Groothuis

Geny M. M. Groothuis

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
14716
World Ranking
10190
National Ranking
261

Overview

Geny M. M. Groothuis is affiliated with the University of Groningen in the Netherlands. Their research spans multiple disciplines, primarily focusing on medicine and biochemistry, genetics, and molecular biology. The scientist's work engages with a variety of specialized subfields including molecular biology, oncology, spectroscopy, pathology and forensic medicine, and pediatrics, perinatology, and child health.

Groothuis has contributed research on several main topics, such as:

  • Drug transport and resistance mechanisms
  • Vitamin D research studies
  • Pharmacological effects and toxicity studies
  • Tryptophan and brain disorders
  • Gut microbiota and health
  • Liver disease diagnosis and treatment
  • Mass spectrometry techniques and applications

The scientist's recent notable publications include:

  • "Significance of the Vitamin D Receptor on Crosstalk with Nuclear Receptors and Regulation of Enzymes and Transporters," 2022, published in The AAPS Journal
  • "Host microbiota dictates the proinflammatory impact of LPS in the murine liver," 2020, published in Toxicology in Vitro
  • "Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags," 2020, published in Chemical Communications
  • "Disruption of vitamin A homeostasis by the biocide tetrakis(hydroxymethyl) phosphonium sulphate in pregnant rabbits," 2022, published in Journal of Applied Toxicology

Groothuis has frequently published in venues such as The AAPS Journal, Toxicology in Vitro, Chemical Communications, and the Journal of Applied Toxicology.

The scientist has collaborated regularly with coauthors including Hjalmar P. Permentier, Keumhan Noh, Edwin C.Y. Chow, Holly P. Quach, and Rommel G. Tirona. These collaborations indicate a multidisciplinary approach to their research topics.

Best Publications

  • Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction.

    Marcella Martignoni;Geny M M Groothuis;Ruben de Kanter

  • Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

    Patricio Godoy;Nicola J. Hewitt;Ute Albrecht;Melvin E. Andersen

  • Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies

    Nicola J. Hewitt;Maria Jose Gomez Lechon;J. Brian Houston;David Hallifax

  • Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport.

    Ronald P.J. Oude Elferink;Dirk K.F. Meijer;Folkert Kuipers;Peter L.M. Jansen

  • Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro.

    Mwn Nijsten;P Olinga;Ege de Vries

  • Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

    Inge A M de Graaf;Peter Olinga;Marina H de Jager;Marjolijn T Merema

  • Comparison of Biocompatibility and Adsorption Properties of Different Plastics for Advanced Microfluidic Cell and Tissue Culture Models

    Paul M. van Midwoud;Arnout Janse;Marjolijn T. Merema;Geny M. M. Groothuis

  • Caffeine-Based Gold(I) N-Heterocyclic Carbenes as Possible Anticancer Agents: Synthesis and Biological Properties

    Benoit Bertrand;Loic Stefan;Marc Pirrotta;David Monchaud

  • Drug uptake systems in liver and kidney

    J. E. van Montfoort;B. Hagenbuch;G. M.M. Groothuis;H. Koepsell

  • LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process

    Marieke G. L. Elferink;Peter Olinga;Annelies L. Draaisma;Marjolijn T. Merema

  • A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

    Paul M. van Midwoud;Marjolijn T. Merema;Elisabeth Verpoorte;Geny M. M. Groothuis

  • Albumin modified with mannose 6-phosphate: A potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells.

    Leonie Beljaars;Grietje Molema;Betty Weert;Harmke Bonnema

  • Targeting Oxidative Stress for the Treatment of Liver Fibrosis.

    Theerut Luangmonkong;Su Suriguga;Henricus A. M. Mutsaers;Geny M. M. Groothuis

  • Precision-cut tissue slices as a tool to predict metabolism of novel drugs

    Inge A. M. de Graaf;Geny M. M. Groothuis;Peter Olinga

  • Autoradiographic and kinetic demonstration of acinar heterogeneity of taurocholate transport

    Geny Groothuis;Mj Hardonk;Kpt Keulemans;P Nieuwenhuis

  • Microfluidic biochip for the perifusion of precision-cut rat liver slices for metabolism and toxicology studies.

    Paul M. van Midwoud;Geny M.M. Groothuis;Marjolijn T. Merema;Elisabeth Verpoorte

  • Selective hepatobiliary transport defect for organic anions and neutral steroids in mutant rats with hereditary-conjugated hyperbilirubinemia

    Peter L. M. Jansen;Geny M. M. Groothuis;Wilbert H. M. Peters;Dirk F. M. Meijer

  • Microfluidic devices for in vitro studies on liver drug metabolism and toxicity.

    Paul M. van Midwoud;Elisabeth Verpoorte;Geny M. M. Groothuis

  • In Vitro Methods to Study Intestinal Drug Metabolism

    Esther G. van de Kerkhof;Inge A. M. de Graaf;Geny M. M. Groothuis

  • Targeting dexamethasone to Kupffer cells: Effects on liver inflammation and fibrosis in rats

    Barbro N. Melgert;Peter Olinga;Judith M.S. Van Der Laan;Betty Weert

Frequent Co-Authors

Dirk K. F. Meijer
Dirk K. F. Meijer University of Groningen
Angela Casini
Angela Casini Technical University of Munich
Meindert Danhof
Meindert Danhof Leiden University
Elisabeth Verpoorte
Elisabeth Verpoorte University of Groningen
Robert J. Porte
Robert J. Porte University Medical Center Groningen
Marianne G. Rots
Marianne G. Rots University Medical Center Groningen
Rainer Bischoff
Rainer Bischoff University of Groningen
Ineke Braakman
Ineke Braakman Utrecht University
Hidde J. Haisma
Hidde J. Haisma University of Groningen
Reinoud Gosens
Reinoud Gosens University of Groningen

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