Bob van de Water

Overview

Best Publications

• Endoplasmic Reticulum Chaperones GRP78 and Calreticulin Prevent Oxidative Stress, Ca2+ Disturbances, and Cell Death in Renal Epithelial Cells

  Hong Liu;Russell C. Bowes;Bob van de Water;Bob van de Water;Christopher Sillence

  463
  Citations

• A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

  Sreenivasa C. Ramaiahgari;Michiel W. den Braver;Bram Herpers;Valeska Terpstra

  424
  Citations

• Adverse outcome pathways: opportunities, limitations and open questions.

  Marcel Leist;Ahmed Ghallab;Ahmed Ghallab;Rabea Graepel;Rosemarie Marchan

  378
  Citations

• Focal adhesion kinase: a potential target in cancer therapy.

  Maroesja J. van Nimwegen;Bob van de Water

  371
  Citations

• Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment.

  Elina Drakvik;Elina Drakvik;Rolf Altenburger;Yasunobu Aoki;Thomas Backhaus

  261
  Citations

• Current EU research activities on combined exposure to multiple chemicals

  Stephanie K. Bopp;Robert Barouki;Werner Brack;Silvia Dalla Costa

  245
  Citations

• Annexin A1 regulates TGF-β signaling and promotes metastasis formation of basal-like breast cancer cells

  Marjo de Graauw;Martine H. van Miltenburg;Marjanka K. Schmidt;Chantal Pont

  232
  Citations

• Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.

  Richard J Weaver;Eric A Blomme;Amy E Chadwick;Ian M Copple

  229
  Citations

• Macrophage p53 Deficiency Leads to Enhanced Atherosclerosis in APOE*3-Leiden Transgenic Mice

  Bart J.M. van Vlijmen;Gery Gerritsen;Arthur L. Franken;Lianne S.M. Boesten

  200
  Citations

• Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes

  Yinghui Zhang;Marja Moerkens;Sreenivasa Ramaiahgari;Hans de Bont

  198
  Citations

• Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways

  Hester Happé;Wouter N. Leonhard;Annemieke van der Wal;Bob van de Water

  189
  Citations

• The membrane attack complex of complement induces caspase activation and apoptosis.

  Alma J. Nauta;Mohamed R. Daha;Odette Tijsma;Bob van de Water

  189
  Citations

• Requirement for Focal Adhesion Kinase in the Early Phase of Mammary Adenocarcinoma Lung Metastasis Formation

  Maroesja J. van Nimwegen;Saertje Verkoeijen;Liesbeth van Buren;Danny Burg

  173
  Citations

• Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development

  Marx U;Akabane T;Andersson Tb;Baker E

  167
  Citations

• A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration

  Keren Yizhak;Sylvia E Le Dévédec;Vasiliki Maria Rogkoti;Franziska Baenke

  156
  Citations

• Toxicogenomics directory of chemically exposed human hepatocytes.

  Marianna Grinberg;Regina M. Stöber;Karolina Edlund;Eugen Rempel

  138
  Citations

• Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer

  Keren Yizhak;Edoardo Gaude;Sylvia Le Dévédec;Yedael Y Waldman

  138
  Citations

• The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals.

  Giel Hendriks;Mirna Atallah;Bruno Morolli;Fabienne Calléja

  131
  Citations

• Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant

  Wies van Roosmalen;Sylvia E. Le Dévédec;Ofra Golani;Marcel Smid

  130
  Citations

• Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cells.

  Merei Huigsloot;Ine B. Tijdens;Gerard J. Mulder;Bob van de Water

  125
  Citations