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Erik H.J. Danen

Erik H.J. Danen

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
11366
World Ranking
16579
National Ranking
400

Overview

Erik H.J. Danen is affiliated with Leiden University in the Netherlands, conducting research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their scholarly contributions focus strongly on subfields such as Oncology, Molecular Biology, Cell Biology, Cancer Research, and Biomedical Engineering.

The scientist's research spans several main topics, including:

  • Cellular Mechanics and Interactions
  • Cancer Cells and Metastasis
  • Cancer, Hypoxia, and Metabolism
  • Cell Adhesion Molecules Research
  • Hippo pathway signaling and YAP/TAZ
  • CAR-T cell therapy research
  • Monoclonal and Polyclonal Antibodies Research

Recent publications authored or co-authored by Danen document specific areas of interest and research activity, including:

  • "Targeting Integrins for Cancer Therapy - Disappointments and Opportunities," 2022, published in Frontiers in Cell and Developmental Biology
  • "Metastasis: crosstalk between tissue mechanics and tumour cell plasticity," 2020, British Journal of Cancer
  • "Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals," 2020, Archives of Toxicology
  • "Mechanical interplay between cell shape and actin cytoskeleton organization," 2020, Soft Matter
  • "Crosstalk between Hypoxia and Extracellular Matrix in the Tumor Microenvironment in Breast Cancer," 2022, Genes

Danen's frequent co-authors include:

  • Thomas Schmidt
  • Chen-Yi Liao
  • Cecilia Bergonzini
  • Bob van de Water
  • Sylvia E. Le Dévédec

Their work has appeared repeatedly in several publication venues, indicating consistent engagement with specific academic communities. These frequent venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancers
  • Archives of Toxicology
  • International Journal of Molecular Sciences
  • Soft Matter

Best Publications

  • Adhesion signaling - crosstalk between integrins, Src and Rho.

    Stephan Huveneers;Erik H. J. Danen

  • Fibronectin, integrins, and growth control.

    Erik H.J. Danen;Kenneth M. Yamada

  • Shc and Fak Differentially Regulate Cell Motility and Directionality Modulated by Pten

    Jianguo Gu;Masahito Tamura;Roumen Pankov;Erik H.J. Danen

  • PTEN Interactions with Focal Adhesion Kinase and Suppression of the Extracellular Matrix-dependent Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway *

    Masahito Tamura;Jianguo Gu;Erik H.J. Danen;Takahisa Takino

  • Integrins in regulation of tissue development and function.

    Erik H J Danen;Arnoud Sonnenberg

  • The fibronectin-binding integrins α5β1 and αvβ3 differentially modulate RhoA–GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis

    Erik H.J. Danen;Petra Sonneveld;Cord Brakebusch;Reinhard Fässler

  • Adverse outcome pathways: opportunities, limitations and open questions.

    Marcel Leist;Ahmed Ghallab;Ahmed Ghallab;Rabea Graepel;Rosemarie Marchan

  • A guide to mechanobiology: Where biology and physics meet.

    Karin A. Jansen;Dominique M. Donato;Hayri E. Balcioglu;Thomas Schmidt

  • Establishment and characterization of an uveal‐melanoma cell line

    I. de Waard-Siebinga;D.J.R. Blom;M. Griffioen;P.I. Schrier

  • Generation of antimelanoma cytotoxic T lymphocytes from healthy donors after presentation of melanoma-associated antigen-derived epitopes by dendritic cells in vitro

    A.B.H. Bakker;G. Marland;A.J. de Boer;R.J.F. Huijbens

  • Integrins control motile strategy through a Rho-cofilin pathway.

    Erik H.J. Danen;Jacco van Rheenen;Willeke Franken;Stephan Huveneers

  • Erratum: Integrins in regulation of tissue development and function. J Pathol; 200: 471–480

    Erik Hj Danen;Arnoud Sonnenberg

  • Neutrophil-Mediated Experimental Metastasis Is Enhanced by VEGFR Inhibition in a Zebrafish Xenograft Model

    Shuning He;Shuning He;Gerda Em Lamers;Jan-Willem M Beenakker;Chao Cui

  • Requirement for the Synergy Site for Cell Adhesion to Fibronectin Depends on the Activation State of Integrin α5β1

    E.H.J. Danen;S.I. Aota;A.A. van Kraats;K.M. Yamada

  • Binding of soluble fibronectin to integrin alpha 5 beta 1 - link to focal adhesion redistribution and contractile shape

    S. Huveneers;S. Huveneers;H. Truong;R. Faessler;A. Sonnenberg

  • Emergence of α5β1 fibronectin‐ and αvβ3 vitronectin‐receptor expression in melanocytic tumour progression

    E.H.J. Danen;P.J.M. Ten Berge;G.N.P. Van Muijen;A.E. Van't Hof-Grootenboer

  • Integrins: regulators of tissue function and cancer progression.

    Erik H.J. Danen

  • Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression.

    Erik H.J. Danen;Petra Sonneveld;Arnoud Sonnenberg;Kenneth M. Yamada

  • E-cadherin expression in human melanoma.

    E H Danen;T J de Vries;R Morandini;Ghanem Elias Ghanem

  • 3D Cell-Based Assays for Drug Screens: Challenges in Imaging, Image Analysis, and High-Content Analysis.

    Tijmen H. Booij;Tijmen H. Booij;Leo S. Price;Erik H. J. Danen

Frequent Co-Authors

Bob van de Water
Bob van de Water Leiden University
Judith V.M.G. Bovée
Judith V.M.G. Bovée Leiden University Medical Center
Arnoud Sonnenberg
Arnoud Sonnenberg Antoni van Leeuwenhoek Hospital
Kenneth M. Yamada
Kenneth M. Yamada National Institutes of Health
Harry Vrieling
Harry Vrieling Leiden University Medical Center
Pancras C.W. Hogendoorn
Pancras C.W. Hogendoorn Leiden University Medical Center
Marcel Leist
Marcel Leist University of Konstanz
Martine J. Jager
Martine J. Jager Leiden University Medical Center
Jacco van Rheenen
Jacco van Rheenen Antoni van Leeuwenhoek Hospital
Herman P. Spaink
Herman P. Spaink Leiden University

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