World's Best Scientists 2026 revealed!
Award Badge
Biology and Biochemistry
UK
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
112
Citations
39856
World Ranking
912
National Ranking
49

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award

Overview

Martin J. Humphries is affiliated with the University of Manchester in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broad areas, they have focused on subfields such as Cell Biology, Molecular Biology, Immunology and Allergy, Oncology, and Cancer Research.

The research topics covered by Humphries include Cell Adhesion Molecules Research, Cellular Mechanics and Interactions, Cancer Cells and Metastasis, Cancer, Hypoxia, and Metabolism, Pancreatic and Hepatic Oncology Research, 3D Printing in Biomedical Research, and Biotin and Related Studies.

Frequent publication venues for Humphries' work include bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Cell and Developmental Biology, Cancer Research, Journal of Biological Chemistry, and Matrix Biology.

Some of the recent published papers by Humphries are as follows:

  • A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids, 2021, Nature Materials
  • Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation, 2020, The Journal of Cell Biology
  • Identification of an Altered Matrix Signature in Kidney Aging and Disease, 2021, Journal of the American Society of Nephrology
  • Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates, 2020, Cancers
  • Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1, 2021, Journal of Biological Chemistry

Humphries collaborates frequently with several coauthors in their research efforts. Notable among these are Jonathan D. Humphries, Janet A. Askari, Claus Jørgensen, David Knight, and Andreja Ambriović-Ristov.

Best Publications

  • Integrin ligands at a glance.

    Jonathan D. Humphries;Adam Byron;Martin J. Humphries

  • Integrin Structure, Activation, and Interactions

    Iain D. Campbell;Martin J. Humphries

  • Vinculin controls focal adhesion formation by direct interactions with talin and actin

    Jonathan D. Humphries;Pengbo Wang;Charles H Streuli;Benny Geiger

  • Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin.

    E A Wayner;A Garcia-Pardo;M J Humphries;J A McDonald

  • A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells.

    Martin J. Humphries;Kenneth Olden;Kenneth Olden;Kenneth M. Yamada

  • Demonstration of catch bonds between an integrin and its ligand

    Fang Kong;Andrés J. García;A. Paul Mould;Martin J. Humphries

  • Synergistic control of cell adhesion by integrins and syndecans

    Mark R. Morgan;Martin J. Humphries;Mark D. Bass

  • Identification of an alternatively spliced site in human plasma fibronectin that mediates cell type-specific adhesion.

    M J Humphries;S K Akiyama;A Komoriya;K Olden

  • Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin.

    Pirkko Huhtala;Martin J. Humphries;James B. McCarthy;Patrice M. Tremble

  • The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine.

    A Komoriya;L J Green;M Mervic;S S Yamada

  • Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

    Edward R. Horton;Adam Byron;Adam Byron;Janet A. Askari;Daniel H. J. Ng

  • Rab25 associates with α5β1 integrin to promote invasive migration in 3D microenvironments

    Patrick T. Caswell;Heather J. Spence;Maddy Parsons;Dominic P. White

  • The molecular basis and specificity of integrin-ligand interactions.

    Martin J. Humphries

  • Identification of two distinct regions of the type III connecting segment of human plasma fibronectin that promote cell type-specific adhesion.

    M J Humphries;A Komoriya;S K Akiyama;K Olden

  • Inhibition of Experimental Metastasis by Castanospermine in Mice: Blockage of Two Distinct Stages of Tumor Colonization by Oligosaccharide Processing Inhibitors

    Martin J. Humphries;Kazue Matsumoto;Sandra L. White;Kenneth Olden

  • Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+.

    A P Mould;S K Akiyama;M J Humphries

  • PKCα regulates β1 integrin‐dependent cell motility through association and control of integrin traffic

    Tony Ng;David Shima;Anthony Squire;Philippe I.H. Bastiaens

  • Linking integrin conformation to function.

    Janet A. Askari;Patrick A. Buckley;A. Paul Mould;Martin J. Humphries

  • Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6

    Jonathan D. Humphries;Jonathan D. Humphries;Adam Byron;Adam Byron;Mark D. Bass;Mark D. Bass;Sue E. Craig;Sue E. Craig

  • Heparin-II domain of fibronectin is a vascular endothelial growth factor-binding domain: Enhancement of VEGF biological activity by a singular growth factor/matrix protein synergism

    Errol S. Wijelath;Salman Rahman;Mayumi Namekata;Jacqueline Murray

Frequent Co-Authors

Ray Boot-Handford
Ray Boot-Handford University of Manchester
Karl E. Kadler
Karl E. Kadler University of Manchester
Kenneth Olden
Kenneth Olden National Institutes of Health
Kenneth M. Yamada
Kenneth M. Yamada National Institutes of Health
Steven K. Akiyama
Steven K. Akiyama National Institutes of Health
Cay M. Kielty
Cay M. Kielty Wellcome Centre for Cell-Matrix Research
Paul N. Bishop
Paul N. Bishop University of Manchester
Andrés J. García
Andrés J. García Georgia Institute of Technology
Tony Ng
Tony Ng King's College London
Roy Zent
Roy Zent Vanderbilt University Medical Center

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Martin J. Humphries

Trending Scientists