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D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
10537
World Ranking
11576
National Ranking
885

Overview

Ray Boot-Handford is affiliated with the University of Manchester in the United Kingdom. Their research focuses primarily on biochemistry, genetics, and molecular biology, with significant contributions intersecting the fields of medicine. The work spans several subfields including cell biology, immunology, surgery, physiology, and genetics.

The scientist has explored a range of topics, notably:

  • Endoplasmic Reticulum Stress and Disease
  • Galectins and Cancer Biology
  • Cardiovascular, Neuropeptides, and Oxidative Stress Research
  • Adipose Tissue and Metabolism
  • High Altitude and Hypoxia
  • Advanced Chemical Sensor Technologies

Their recent publication record includes work published in notable journals such as the Journal of Bone and Mineral Research and Osteoarthritis and Cartilage. Recent papers include:

  • "CRELD2 Is a Novel LRP1 Chaperone That Regulates Noncanonical WNT Signaling in Skeletal Development," 2020, Journal of Bone and Mineral Research
  • "Circadian time series proteomics reveals daily dynamics in cartilage physiology," 2021, Osteoarthritis and Cartilage

Their research team includes frequent collaborators such as Ella P. Dennis, Sarah Edwards, Robert M. Jackson, Claire Hartley, and Dimitra Tsompani.

Best Publications

  • Collagens at a glance

    Karl E. Kadler;Clair Baldock;Jordi Bella;Raymond P. Boot-Handford

  • Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins.

    Qing Jun Meng;Larisa Logunova;Elizabeth S. Maywood;Monica Gallego

  • Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch

    Rebecca J Richardson;Jill Dixon;Saimon Malhotra;Matthew J Hardman

  • Genetic diseases of connective tissues: cellular and extracellular effects of ECM mutations

    John F. Bateman;Raymond P. Boot-Handford;Shireen R. Lamandé

  • The expression and function of microRNAs in chondrogenesis and osteoarthritis.

    Tracey E Swingler;Guy Wheeler;Virginia Carmont;Hannah R Elliott

  • Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

    Jenny L Scott;Christos Gabrielides;Rose K Davidson;Tracey E Swingler

  • Fibrillar collagen: the key to vertebrate evolution? A tale of molecular incest.

    Raymond P. Boot-Handford;Danny S. Tuckwell

  • A novel and highly conserved collagen (proα1(XXVII)) with a unique expression pattern and unusual molecular characteristics establishes a new clade within the vertebrate fibrillar collagen family

    Raymond P. Boot-Handford;Danny S. Tuckwell;Darren A. Plumb;Claire Farrington Rock

  • The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity

    Michal Dudek;Nicole Gossan;Nan Yang;Hee-Jeong Im

  • Distribution of type X collagen mRNA in normal and osteoarthritic human cartilage

    Judith A. Hoyland;J.T. Thomas;R. Donn;A. Marriott

  • The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage Homeostasis

    Nicole Gossan;Leo Zeef;James Hensman;Alun Hughes

  • Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway

    Xin Wang;Anita J. Merritt;Jan Seyfried;Chun Guo

  • The unfolded protein response and its relevance to connective tissue diseases

    Raymond P. Boot-Handford;Michael D. Briggs

  • Bub1 Maintains Centromeric Cohesion by Activation of the Spindle Checkpoint

    David Perera;Valerie Tilston;Jane A. Hopwood;Marco Barchi

  • The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio

    Julie Huxley-Jones;Toni Kim Clarke;Toni Kim Clarke;Christine Beck;George Toubaris

  • Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy

    C J Brew;P D Clegg;R P Boot-Handford;J G Andrew

  • Lineage tracing using matrilin-1 gene expression reveals that articular chondrocytes exist as the joint interzone forms.

    Gareth Hyde;Sharon Dover;Attila Aszodi;Gillian A. Wallis

  • Targeted induction of endoplasmic reticulum stress induces cartilage pathology

    M. Helen Rajpar;Ben McDermott;Louise Kung;Rachel Eardley

  • The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration

    Michal Dudek;Nan Yang;Nan Yang;Jayalath Pd Ruckshanthi;Jayalath Pd Ruckshanthi;Jack Williams;Jack Williams

  • On the origins of the extracellular matrix in vertebrates.

    Julie Huxley-Jones;David L. Robertson;Raymond P. Boot-Handford;Raymond P. Boot-Handford

Frequent Co-Authors

Karl E. Kadler
Karl E. Kadler University of Manchester
Martin J. Humphries
Martin J. Humphries University of Manchester
Michael E. Grant
Michael E. Grant Wellcome Centre for Cell-Matrix Research
John F. Bateman
John F. Bateman University of Melbourne
David J. Thornton
David J. Thornton Wellcome Centre for Cell-Matrix Research
Timothy E. Hardingham
Timothy E. Hardingham Wellcome Centre for Cell-Matrix Research
Judith A. Hoyland
Judith A. Hoyland University of Manchester
David Robertson
David Robertson Vanderbilt University
Richard Poulsom
Richard Poulsom Queen Mary University of London
Anthony J. Freemont
Anthony J. Freemont University of Manchester

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