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D-Index & Metrics

Biology and Biochemistry

D-Index
75
Citations
19665
World Ranking
5327
National Ranking
411

Overview

Karl E. Kadler is affiliated with the University of Manchester in the United Kingdom. Their research focuses primarily on areas within Medicine and Biochemistry, Genetics, and Molecular Biology. The work spans several subfields including Cell Biology, Physiology, Orthopedics and Sports Medicine, Cancer Research, and Genetics.

The scientist's main topics of investigation include:

  • Tendon Structure and Treatment
  • Protease and Inhibitor Mechanisms
  • Cellular Mechanics and Interactions
  • Connective Tissue Disorders Research
  • Spaceflight Effects on Biology
  • Muscle Metabolism and Nutrition
  • Cell Adhesion Molecules Research

Karl E. Kadler has contributed articles to a variety of publication venues, with multiple works appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal
  • Matrix Biology Plus
  • Cells
  • Matrix Biology

Recent notable papers include:

  • Circadian control of the secretory pathway maintains collagen homeostasis, 2020, Nature Cell Biology
  • Collagen fibril assembly: New approaches to unanswered questions, 2021, Matrix Biology Plus
  • Collagen Assembly at the Cell Surface: Dogmas Revisited, 2021, Cells
  • The clock transcription factor BMAL1 is a key regulator of extracellular matrix homeostasis and cell fate in the intervertebral disc, 2023, Matrix Biology
  • Circadian time series proteomics reveals daily dynamics in cartilage physiology, 2021, Osteoarthritis and Cartilage

Frequent collaborators in their research include Yinhui Lu, Adam Pickard, Joan Chang, Richa Garva, and Qing-Jun Meng. These partnerships reflect a continuous engagement in collaborative, interdisciplinary projects.

Best Publications

  • Collagen fibril formation

    Karl E. Kadler;David F. Holmes;John A. Trotter;John A. Chapman

  • Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility

    Keith G. Danielson;Helene Baribault;David F. Holmes;Helen Graham

  • Collagens at a glance

    Karl E. Kadler;Clair Baldock;Jordi Bella;Raymond P. Boot-Handford

  • Procollagen trafficking, processing and fibrillogenesis

    Elizabeth G. Canty;Karl E. Kadler

  • Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators.

    Karl E Kadler;Adele Hill;Elizabeth G Canty-Laird

  • Assembly of collagen fibrils de novo by cleavage of the type I pC-collagen with procollagen C-proteinase. Assay of critical concentration demonstrates that collagen self-assembly is a classical example of an entropy-driven process.

    K E Kadler;Y Hojima;D J Prockop

  • Coalignment of plasma membrane channels and protrusions (fibripositors) specifies the parallelism of tendon.

    Elizabeth G. Canty;Yinhui Lu;Roger S. Meadows;Michael K. Shaw

  • Corneal collagen fibril structure in three dimensions: Structural insights into fibril assembly, mechanical properties, and tissue organization

    David F. Holmes;Christopher J. Gilpin;Clair Baldock;Ulrike Ziese

  • Using transmission electron microscopy and 3View to determine collagen fibril size and three-dimensional organization

    Tobias Starborg;Nicholas S Kalson;Nicholas S Kalson;Yinhui Lu;Yinhui Lu;Aleksandr Mironov

  • Transcription factor EGR1 directs tendon differentiation and promotes tendon repair

    Marie Justine Guerquin;Benjamin Charvet;Geoffroy Nourissat;Emmanuelle Havis

  • Cartilage Oligomeric Matrix Protein Interacts with Type IX Collagen, and Disruptions to These Interactions Identify a Pathogenetic Mechanism in a Bone Dysplasia Family

    Paul Holden;Roger S. Meadows;Kathryn L. Chapman;Michael E. Grant

  • Tendon functional extracellular matrix.

    Hazel R C Screen;David E Berk;Karl E Kadler;Francesco Ramirez

  • Identification of collagen fibril fusion during vertebrate tendon morphogenesis. The process relies on unipolar fibrils and is regulated by collagen-proteoglycan interaction.

    Helen K Graham;David F Holmes;Rod B Watson;Karl E Kadler

  • The collagen fibril--a model system for studying the staining and fixation of a protein.

    John A. Chapman;Margaret Tzaphlidou;Keith M. Meek;Karl E. Kadler

  • Age-Related Changes on the Surface of Vitreous Collagen Fibrils

    Paul N. Bishop;Paul N. Bishop;David F. Holmes;Karl E. Kadler;David McLeod

  • Lysyl Oxidase Activity Is Required for Ordered Collagen Fibrillogenesis by Tendon Cells

    Andreas Herchenhan;Franziska Uhlenbrock;Pernilla Eliasson;MaryAnn Weis

  • The supramolecular organization of fibrillin-rich microfibrils.

    Clair Baldock;Abraham J. Koster;Ulrike Ziese;Matthew J. Rock

  • Extracellular matrix. 1: fibril-forming collagens.

    Kadler K

  • Copolymerization of pNcollagen III and collagen I. pNcollagen III decreases the rate of incorporation of collagen I into fibrils, the amount of collagen I incorporated, and the diameter of the fibrils formed.

    A M Romanic;E Adachi;K E Kadler;Y Hojima

  • Collagen Fibril Assembly and Function.

    David F Holmes;Yinhui Lu;Tobias Starborg;Karl E Kadler

Frequent Co-Authors

Ray Boot-Handford
Ray Boot-Handford University of Manchester
Martin J. Humphries
Martin J. Humphries University of Manchester
Darwin J. Prockop
Darwin J. Prockop Texas A&M University
Neil J. Bulleid
Neil J. Bulleid University of Glasgow
David J. Thornton
David J. Thornton Wellcome Centre for Cell-Matrix Research
Alexander A. Mironov
Alexander A. Mironov University of Manchester
Paul N. Bishop
Paul N. Bishop University of Manchester
Peter H. Byers
Peter H. Byers University of Washington
Michael Kjaer
Michael Kjaer University of Copenhagen
David J. S. Hulmes
David J. S. Hulmes Claude Bernard University Lyon 1

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