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Biology and Biochemistry

D-Index
74
Citations
16673
World Ranking
5714
National Ranking
440

Overview

David J. Thornton is affiliated with the Wellcome Centre for Cell-Matrix Research in the United Kingdom. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a strong focus on Molecular Biology, Pulmonary and Respiratory Medicine, Immunology, Organic Chemistry, and Parasitology.

The scientist's main topics of work include Glycosylation and Glycoproteins Research, Carbohydrate Chemistry and Synthesis, Parasites and Host Interactions, Cystic Fibrosis Research Advances, Proteoglycans and glycosaminoglycans research, Gut microbiota and health, and IL-33, ST2, and ILC Pathways.

Recent publications by David J. Thornton cover a variety of subjects within molecular and respiratory biology. These include:

  • "Mucus" (2021) published in Current Biology
  • "Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B" (2021) published in Proceedings of the National Academy of Sciences
  • "Disulfide disruption reverses mucus dysfunction in allergic airway disease" (2021) published in Nature Communications
  • "Defining the early stages of intestinal colonisation by whipworms" (2022) published in Nature Communications
  • "Mucin networks: Dynamic structural assemblies controlling mucus function" (2023) published in Current Opinion in Structural Biology

Frequent co-authors working with David J. Thornton include Caroline Ridley, Richard K. Grencis, Camille Ehré, Kelly S. Hayes, and Richard F. Collins.

The scientist's work is often published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Scientific Reports, Nature Communications, Journal of the American Medical Informatics Association, and UNC Libraries.

Best Publications

  • A population of fast radio bursts at cosmological distances.

    D. Thornton;D. Thornton;B. Stappers;M. Bailes;M. Bailes;B. Barsdell;B. Barsdell

  • Structure and Function of the Polymeric Mucins in Airways Mucus

    David J. Thornton;Karine Rousseau;Michael A. McGuckin

  • Muc5b is required for airway defence

    Michelle G. Roy;Alessandra Livraghi-Butrico;Ashley A. Fletcher;Melissa M. McElwee

  • Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.

    Chad K Heazlewood;Matthew C Cook;Rajaraman Eri;Gareth R Price

  • From mucins to mucus: toward a more coherent understanding of this essential barrier.

    David J Thornton;John K Sheehan

  • Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B.

    Sara Kirkham;John K Sheehan;David Knight;Paul S Richardson

  • Muc5ac: a critical component mediating the rejection of enteric nematodes

    Sumaira Z. Hasnain;Christopher M. Evans;Michelle Roy;Amanda L. Gallagher

  • Five new fast radio bursts from the HTRU high-latitude survey at Parkes: First evidence for two-component bursts

    D. J. Champion;E. Petroff;E. Petroff;M. Kramer;M. Kramer;M. J. Keith

  • Endothelial function in HIV-infected persons.

    Anthony Solages;Joseph A. Vita;David J. Thornton;Jessica Murray

  • Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?

    Mehmet Kesimer;Sara Kirkham;Raymond J. Pickles;Ashley G. Henderson

  • Respiratory mucins: identification of core proteins and glycoforms.

    David J. Thornton;Ingemar Carlstedt;Marj Howard;Peter L. Devine

  • Identification of Two Glycoforms of the MUC5B Mucin in Human Respiratory Mucus EVIDENCE FOR A CYSTEINE-RICH SEQUENCE REPEATED WITHIN THE MOLECULE

    David J. Thornton;Marj Howard;Nagma Khan;John K. Sheehan

  • Mucin Gene Deficiency in Mice Impairs Host Resistance to an Enteric Parasitic Infection

    Sumaira Z. Hasnain;Huaqing Wang;Jean–Eric Ghia;Nihal Haq

  • Hepatitis C Virus and Human Immunodeficiency Virus Coinfection in an Urban Population: Low Eligibility for Interferon Treatment

    Catherine A. Fleming;Donald E. Craven;David Thornton;Sheila Tumilty

  • The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation.

    Freya R Svedberg;Freya R Svedberg;Sheila L Brown;Maria Z Krauss;Laura Campbell

  • Mucins: the frontline defence of the lung

    Caroline Ridley;David J. Thornton

  • SALIVARY MUCIN MG1 IS COMPRISED ALMOST ENTIRELY OF DIFFERENT GLYCOSYLATED FORMS OF THE MUC5B GENE PRODUCT

    David J. Thornton;Nagma Khan;Ravi Mehrotra;Marj Howard

  • Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus.

    Bertrand D.E. Raynal;Timothy E. Hardingham;John K. Sheehan;David J. Thornton

  • Pharmacodynamics of thrombolysis with recombinant tissue-type plasminogen activator. Correlation with characteristics of and clinical outcomes in patients with acute myocardial infarction. The TAMI Study Group.

    D C Stump;R M Califf;E J Topol;K Sigmon

  • MUC5B Is the Major Mucin in the Gel Phase of Sputum in Chronic Obstructive Pulmonary Disease

    Sara Kirkham;Umme Kolsum;Karine Rousseau;Dave Singh

Frequent Co-Authors

John K. Sheehan
John K. Sheehan University of North Carolina at Chapel Hill
Richard K. Grencis
Richard K. Grencis University of Manchester
Michael Kramer
Michael Kramer Max Planck Institute for Radio Astronomy
Matthew Bailes
Matthew Bailes Swinburne University of Technology
W. van Straten
W. van Straten Auckland University of Technology
Simon Johnston
Simon Johnston Australia Telescope National Facility
Ray Boot-Handford
Ray Boot-Handford University of Manchester
Michael A. McGuckin
Michael A. McGuckin University of Melbourne
Ingemar Carlstedt
Ingemar Carlstedt Lund University
Andrea Possenti
Andrea Possenti National Institute for Astrophysics

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