John K. Sheehan

Overview

Best Publications

• A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia

  Brian Button;Li Heng Cai;Camille Ehre;Mehmet Kesimer

  836
  Citations

• From mucins to mucus: toward a more coherent understanding of this essential barrier.

  David J Thornton;John K Sheehan

  443
  Citations

• Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B.

  Sara Kirkham;John K Sheehan;David Knight;Paul S Richardson

  411
  Citations

• Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense

  Mehmet Kesimer;Margaret Scull;Brian Brighton;Genevieve DeMaria

  409
  Citations

• Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure

  Ashley Glyn Henderson;Camille Ehre;Brian M Button;Lubna H. Abdullah

  347
  Citations

• Isolation and characterization of human cervical-mucus glycoproteins

  I Carlstedt;H Lindgren;J K Sheehan;U Ulmsten

  288
  Citations

• Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?

  Mehmet Kesimer;Sara Kirkham;Raymond J. Pickles;Ashley G. Henderson

  246
  Citations

• Mucin gene expression during differentiation of human airway epithelia in vitro. Muc4 and muc5b are strongly induced.

  Susan H. Bernacki;Andrew L. Nelson;Lubna Abdullah;John K. Sheehan

  243
  Citations

• Respiratory mucins: identification of core proteins and glycoforms.

  David J. Thornton;Ingemar Carlstedt;Marj Howard;Peter L. Devine

  241
  Citations

• Molecular Organization of the Mucins and Glycocalyx Underlying Mucus Transport Over Mucosal Surfaces of the Airways

  M Kesimer;C Ehre;K A Burns;C W Davis

  234
  Citations

• Identification of Two Glycoforms of the MUC5B Mucin in Human Respiratory Mucus EVIDENCE FOR A CYSTEINE-RICH SEQUENCE REPEATED WITHIN THE MOLECULE

  David J. Thornton;Marj Howard;Nagma Khan;John K. Sheehan

  227
  Citations

• Electron microscopy of cervical, gastric and bronchial mucus glycoproteins.

  J K Sheehan;K Oates;I Carlstedt

  209
  Citations

• Hyaluronan: polysaccharide chaos to protein organisation

  Anthony J Day;John K Sheehan

  202
  Citations

• The macromolecular structure of human cervical-mucus glycoproteins. Studies on fragments obtained after reduction of disulphide bridges and after subsequent trypsin digestion.

  I Carlstedt;H Lindgren;J K Sheehan

  180
  Citations

• Reduced three-dimensional motility in dehydrated airway mucus prevents neutrophil capture and killing bacteria on airway epithelial surfaces.

  Hirotoshi Matsui;Margrith W. Verghese;Mehmet Kesimer;Ute E. Schwab

  179
  Citations

• SALIVARY MUCIN MG1 IS COMPRISED ALMOST ENTIRELY OF DIFFERENT GLYCOSYLATED FORMS OF THE MUC5B GENE PRODUCT

  David J. Thornton;Nagma Khan;Ravi Mehrotra;Marj Howard

  179
  Citations

• Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus.

  Bertrand D.E. Raynal;Timothy E. Hardingham;John K. Sheehan;David J. Thornton

  178
  Citations

• Characterization of two different glycosylated domains from the insoluble mucin complex of rat small intestine.

  I Carlstedt;A Herrmann;Hasse Karlsson;J Sheehan

  172
  Citations

• Identification in Vitreous and Molecular Cloning of Opticin, a Novel Member of the Family of Leucine-rich Repeat Proteins of the Extracellular Matrix

  Anthony J. Reardon;Anthony J. Reardon;Magali Le Goff;Magali Le Goff;Michael D. Briggs;David McLeod

  156
  Citations

• Mucus glycoproteins from 'normal' human tracheobronchial secretion

  D J Thornton;J R Davies;M Kraayenbrink;P S Richardson

  154
  Citations