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Biology and Biochemistry
USA
2023

D-Index & Metrics

Medicine

D-Index
156
Citations
80800
World Ranking
922
National Ranking
524

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in United States Leader Award

Overview

Richard C. Boucher is a researcher affiliated with the University of North Carolina at Chapel Hill in the United States. Their primary field of study is Medicine, with a significant focus on subfields including Pulmonary and Respiratory Medicine, Infectious Diseases, Molecular Biology, Physiology, and Epidemiology.

Their recent scientific contributions include five notable papers published between 2020 and 2021. These papers cover important topics related to respiratory diseases and viral infections:

  • SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract (2020, Cell)
  • SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo (2020, Science)
  • SARS-CoV-2 infection of the oral cavity and saliva (2021, Nature Medicine)
  • A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice (2020, Cell)
  • Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction (2020, Cell Stem Cell)

Richard C. Boucher's research topics prominently feature respiratory system health and disease. Main areas of work include:

  • Cystic Fibrosis Research Advances
  • Neonatal Respiratory Health Research
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • SARS-CoV-2 and COVID-19 Research
  • Tracheal and airway disorders
  • Respiratory viral infections research
  • Pediatric health and respiratory diseases

Throughout their career, Boucher has collaborated frequently with several researchers, indicating a broad network of co-authors. These frequent collaborators include:

  • Wanda K. O'Neal
  • Kenichi Okuda
  • Scott H. Randell
  • Rodney C. Gilmore
  • Ralph S. Baric

The venues chosen for publication reflect Boucher's research emphasis on respiratory and infectious diseases. The most frequent publication platforms are:

  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • American Journal of Respiratory and Critical Care Medicine
  • Journal of Cystic Fibrosis
  • Cell

Richard C. Boucher's work is embedded in multiple intertwined disciplines that contribute to understanding respiratory health and infectious diseases, with particular attention to viral pathogens affecting the respiratory tract. Their research has been disseminated in journals known for advancing knowledge in medicine and pulmonary sciences, supporting ongoing investigation and clinical insights.

Best Publications

  • SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.

    Yixuan J. Hou;Kenichi Okuda;Caitlin E. Edwards;David R. Martinez

  • Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients

    Dieter Worlitzsch;Robert Tarran;Martina Ulrich;Ute Schwab

  • Mucus clearance as a primary innate defense mechanism for mammalian airways

    Michael R. Knowles;Richard C. Boucher

  • Evidence for Periciliary Liquid Layer Depletion, Not Abnormal Ion Composition, in the Pathogenesis of Cystic Fibrosis Airways Disease

    Hirotoshi Matsui;Barbara R Grubb;Robert Tarran;Scott H Randell

  • CFTR as a cAMP-dependent regulator of sodium channels.

    MJ Stutts;CM Canessa;JC Olsen;M Hamrick

  • An Animal Model for Cystic Fibrosis Made by Gene Targeting

    John N. Snouwaert;Kristen K. Brigman;Anne M. Latour;Nadia N. Malouf

  • Correction: Corrigendum: Non-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo

    Martin Donnelley;Kaye S. Morgan;Karen K. W. Siu;Nigel R. Farrow

  • Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice.

    Marcus Mall;Barbara R Grubb;Jack R Harkema;Wanda K O'Neal

  • Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice

    Edith Hummler;Pierre Barker;John Gatzy;Friedrich Beermann

  • SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

    Yixuan J. Hou;Shiho Chiba;Peter Halfmann;Camille Ehre

  • Mucus clearance and lung function in cystic fibrosis with hypertonic saline.

    Scott H. Donaldson;William D. Bennett;Kirby L. Zeman;Michael R. Knowles

  • Muc5b is required for airway defence

    Michelle G. Roy;Alessandra Livraghi-Butrico;Ashley A. Fletcher;Melissa M. McElwee

  • A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia

    Brian Button;Li Heng Cai;Camille Ehre;Mehmet Kesimer

  • New concepts of the pathogenesis of cystic fibrosis lung disease.

    Boucher Rc

  • Submucosal glands are the predominant site of CFTR expression in the human bronchus.

    John F. Engelhardt;James R. Yankaskas;Stephen A. Ernst;Yiping Yang

  • Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.

    Balazs Sarkadi;Elmer M. Price;Richard C. Boucher;Ursula A. Germann

  • Increased Bioelectric Potential Difference across Respiratory Epithelia in Cystic Fibrosis

    Michael R Knowles;John Gatzy;Richard C Boucher

  • Pseudomonas aeruginosa Anaerobic Respiration in Biofilms: Relationships to Cystic Fibrosis Pathogenesis

    Sang Sun Yoon;Robert F. Hennigan;George M. Hilliard;Urs A. Ochsner

  • A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis

    Michael R Knowles;Kathy W. Hohneker;Zhaoqing Zhou;John C. Olsen

  • Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation.

    R C Boucher;M J Stutts;M R Knowles;L Cantley

Frequent Co-Authors

Michael R. Knowles
Michael R. Knowles University of North Carolina at Chapel Hill
Wanda K. O'Neal
Wanda K. O'Neal University of North Carolina at Chapel Hill
Eduardo R. Lazarowski
Eduardo R. Lazarowski University of North Carolina at Chapel Hill
Scott H. Randell
Scott H. Randell University of North Carolina at Chapel Hill
John C. Olsen
John C. Olsen University of North Carolina at Chapel Hill
Robert Tarran
Robert Tarran University of North Carolina at Chapel Hill
Michael M. Tunney
Michael M. Tunney Queen's University Belfast
Marcus A. Mall
Marcus A. Mall Charité - University Medicine Berlin
M. Jackson Stutts
M. Jackson Stutts University of North Carolina at Chapel Hill
Matthew C. Wolfgang
Matthew C. Wolfgang University of North Carolina at Chapel Hill

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