World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
12771
World Ranking
10325
National Ranking
4495

Research.com Recognitions

  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1977 - Fellow of Alfred P. Sloan Foundation

Overview

Jeffrey J. Wine is affiliated with Stanford University in the United States and has contributed extensively to research in medicine, with a significant focus on pulmonary and respiratory medicine. Their work predominantly centers on cystic fibrosis and related respiratory disorders, blending molecular biology, physiology, and clinical insights into respiratory health.

Their recent research includes studies such as "Transgenic ferret models define pulmonary ionocyte diversity and function" (2023, Nature), "Targeted replacement of full-length CFTR in human airway stem cells by CRISPR-Cas9 for pan-mutation correction in the endogenous locus" (2021, Molecular Therapy), and "How the sweat gland reveals levels of CFTR activity" (2022, Journal of Cystic Fibrosis). Additional notable papers include "Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus" (2021, bioRxiv (Cold Spring Harbor Laboratory)) and "Combined agonists act synergistically to increase mucociliary clearance in a cystic fibrosis airway model" (2021, Scientific Reports).

Frequent coauthors in Jeffrey J. Wine's research include:

  • Nam Soo Joo
  • Carlos Milla
  • Sriram Vaidyanathan
  • Dawn T. Bravo
  • Tushar Desai

Their publications appear primarily in the following scientific venues:

  • Journal of Cystic Fibrosis
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Molecular Therapy
  • PNAS Nexus

Jeffrey J. Wine's research spans multiple subfields including pulmonary and respiratory medicine, molecular biology, physiology, electrical and electronic engineering, and ecology, with a predominant emphasis on respiratory and molecular medical sciences.

The main topics addressed in their work are:

  • Cystic Fibrosis Research Advances
  • Neonatal Respiratory Health Research
  • Tracheal and airway disorders
  • Energy Harvesting in Wireless Networks
  • CRISPR and Genetic Engineering
  • Asthma and respiratory diseases
  • Inhalation and Respiratory Drug Delivery

Recognition of Jeffrey J. Wine's contributions includes being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2006 and a Fellow of the Alfred P. Sloan Foundation in 1977.

Best Publications

  • Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

    Fredrick Van Goor;Sabine Hadida;Peter D. J. Grootenhuis;Bill Burton

  • Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation.

    Sachiko Sato;Cristina L. Ward;Mauri E. Krouse;Jeffrey J. Wine

  • Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl- secretion

    B. Q. Shen;W. E. Finkbeiner;J. J. Wine;R. J. Mrsny

  • Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis

    Xingshen Sun;Hongshu Sui;John T. Fisher;Ziying Yan

  • The organization of escape behaviour in the crayfish.

    Jeffrey J. Wine;Franklin B. Krasne

  • The genesis of cystic fibrosis lung disease

    Jeffrey J. Wine

  • A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies.

    John A. Wagner;Ilynn B. Nepomuceno;Anna H. Messner;Mary Lynn Moran

  • Efficient and persistent gene transfer of AAV-CFTR in maxillary sinus

    John A Wagner;Thomas Reynolds;Mary Lynn Moran;Richard B Moss

  • Submucosal Glands and Airway Defense

    Jeffrey J. Wine;Nam Soo Joo

  • Safety and biological efficacy of an adeno-associated virus vector-cystic fibrosis transmembrane regulator (AAV-CFTR) in the cystic fibrosis maxillary sinus.

    John A. Wagner;Anna H. Messner;Mary Lynn Moran;Richard Daifuku

  • Submucosal gland secretions in airways from cystic fibrosis patients have normal [Na+] and pH but elevated viscosity

    Sujatha Jayaraman;Nam Soo Joo;Bruce Reitz;Jeffrey J. Wine

  • The Structural Basis of an Innate Behavioural Pattern

    Jeffrey J. Wine

  • Failure of the cystic fibrosis transmembrane conductance regulator to conduct ATP.

    M. M. Reddy;P. M. Quinton;C. Haws;J. J. Wine

  • Airway Gland Structure and Function.

    Jonathan H. Widdicombe;Jeffrey J. Wine;Jeffrey J. Wine

  • CFTR in Calu-3 human airway cells: channel properties and role in cAMP-activated Cl- conductance

    C. Haws;W. E. Finkbeiner;Jonathan Widdicombe;J. J. Wine

  • Swelling-induced and depolarization-induced C1-channels in normal and cystic fibrosis epithelial cells

    C. K. Solc;J. J. Wine

  • Delta F508-CFTR channels: kinetics, activation by forskolin, and potentiation by xanthines

    C. M. Haws;I. B. Nepomuceno;M. E. Krouse;H. Wakelee

  • Parasympathetic control of airway submucosal glands: central reflexes and the airway intrinsic nervous system.

    Jeffrey J. Wine

  • Connectivity patterns of crayfish giant interneurons: visualization of synaptic regions with cobalt dye.

    Jay E. Mittenthal;Jeffrey J. Wine

  • Physiological consequences of a peptide cotransmitter in a crayfish nerve-muscle preparation

    Bishop Ca;Wine Jj;Nagy F;O'Shea Mr

Frequent Co-Authors

Richard B. Moss
Richard B. Moss Stanford University
Jonathan Widdicombe
Jonathan Widdicombe University of California, Davis
John A. Wagner
John A. Wagner Cygnal Therapeutics (United States)
John W. Hanrahan
John W. Hanrahan McGill University
Heinrich Reichert
Heinrich Reichert University of Basel
Gang Bao
Gang Bao Rice University
Terence R. Flotte
Terence R. Flotte University of Massachusetts Chan Medical School
Matthew H. Porteus
Matthew H. Porteus Stanford University
Robert C. Robbins
Robert C. Robbins Stanford University
Michael Dean
Michael Dean National Institutes of Health

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