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Biology and Biochemistry
USA
2025

D-Index & Metrics

Medicine

D-Index
155
Citations
81279
World Ranking
975
National Ranking
559

Research.com Recognitions

  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2000 - Member of the National Academy of Sciences
  • 1999 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1998 - Fellow of the American Academy of Arts and Sciences

Overview

Michael J. Welsh is affiliated with the University of Iowa in the United States. Their research primarily spans the field of Medicine, with a concentration in Pulmonary and Respiratory Medicine, Molecular Biology, Physiology, Cellular and Molecular Neuroscience, and Genetics.

The research work of Michael J. Welsh addresses several main topics, including:

  • Cystic Fibrosis Research Advances
  • Neonatal Respiratory Health Research
  • Tracheal and airway disorders
  • Inhalation and Respiratory Drug Delivery
  • Asthma and respiratory diseases
  • Pediatric health and respiratory diseases
  • Parkinson's Disease Mechanisms and Treatments

Frequent co-authors collaborating with Michael J. Welsh include:

  • David A. Stoltz
  • Ian M. Thornell
  • Tayyab Rehman
  • Alejandro A. Pezzulo
  • Nandakumar S. Narayanan

Michael J. Welsh has published extensively in the following venues:

  • Journal of Cystic Fibrosis
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Investigation
  • Proceedings of the National Academy of Sciences
  • American Journal of Physiology-Cell Physiology

Selected recent papers include:

  • "Association of Glycolysis-Enhancing α-1 Blockers With Risk of Developing Parkinson Disease," 2021, JAMA Neurology
  • "Combining Ivacaftor and Intensive Antibiotics Achieves Limited Clearance of Cystic Fibrosis Infections," 2021, mBio
  • "CFTR-rich ionocytes mediate chloride absorption across airway epithelia," 2023, Journal of Clinical Investigation
  • "Inflammatory cytokines TNF-α and IL-17 enhance the efficacy of cystic fibrosis transmembrane conductance regulator modulators," 2021, Journal of Clinical Investigation
  • "A pilot to assess target engagement of terazosin in Parkinson's disease," 2021, Parkinsonism & Related Disorders

The scientist is a member of the National Academy of Sciences since 2000 and was awarded fellowships by the American Association for the Advancement of Science in 1999 and the American Academy of Arts and Sciences in 1998.

Best Publications

  • Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis

    Michael J. Welsh;Alan E. Smith

  • Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms

    Pradeep K. Singh;Amy L. Schaefer;Matthew R. Parsek;Thomas O. Moninger

  • Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid

    Joseph Zabner;Al J. Fasbender;Tom Moninger;Kristi A. Poellinger

  • Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface Fluid

    Jeffrey J Smith;Sue M Travis;E.Peter Greenberg;Michael J Welsh;Michael J Welsh

  • Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive.

    Gerene M. Denning;Matthew P. Anderson;Jane F. Amara;John Marshall

  • Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity

    Matthew P. Anderson;Richard J. Gregory;Simon Thompson;David W. Souza

  • Structure and Function of the CFTR Chloride Channel

    David N. Sheppard;Michael J. Welsh

  • A component of innate immunity prevents bacterial biofilm development

    Pradeep K. Singh;Matthew R. Parsek;E. Peter Greenberg;E. Peter Greenberg;Michael J. Welsh;Michael J. Welsh;Michael J. Welsh

  • Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.

    Zhi-Gang Xiong;Xiao-Man Zhu;Xiang-Ping Chu;Manabu Minami

  • Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

    Alejandro A. Pezzulo;Xiao Xiao Tang;Mark J. Hoegger;Mahmoud H. Abou Alaiwa

  • Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs.

    Christopher S. Rogers;David A. Stoltz;David K. Meyerholz;Lynda S. Ostedgaard

  • Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis

    Joseph Zabner;Larry A. Couture;Richard J. Gregory;Scott M. Graham

  • Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells.

    Devra P. Rich;Matthew P. Anderson;Richard J. Gregory;Seng H. Cheng

  • Production of β-defensins by human airway epithelia

    Pradeep K. Singh;Hong Peng Jia;Kerry Wiles;Jay Hesselberth

  • Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

    S.H. Cheng;D.P. Rich;J. Marshall;R.J. Gregory

  • The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory.

    John A. Wemmie;Jianguo Chen;Jianguo Chen;Candice C. Askwith;Candice C. Askwith;Alesia M. Hruska-Hageman;Alesia M. Hruska-Hageman

  • Motile Cilia of Human Airway Epithelia Are Chemosensory

    Alok S. Shah;Yehuda Ben-Shahar;Yehuda Ben-Shahar;Thomas O. Moninger;Joel N. Kline

  • Origins of Cystic Fibrosis Lung Disease

    David A. Stoltz;David K. Meyerholz;Michael J. Welsh

  • The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice

    Margaret P. Price;Sabrina L. McIlwrath;Jinghui Xie;Chun Cheng

  • Generation of cAMP-activated chloride currents by expression of CFTR

    Matthew P. Anderson;Devra P. Rich;Richard J. Gregory;Alan E. Smith

Frequent Co-Authors

Joseph Zabner
Joseph Zabner University of Iowa
David A. Stoltz
David A. Stoltz University of Iowa
John A. Wemmie
John A. Wemmie University of Iowa
Paul B. McCray
Paul B. McCray University of Iowa
David K. Meyerholz
David K. Meyerholz University of Iowa
Alan E. Smith
Alan E. Smith Sanofi (United States)
Richard J. Gregory
Richard J. Gregory Sanofi (United States)
Randall S. Prather
Randall S. Prather University of Missouri
Pradeep K. Singh
Pradeep K. Singh University of Washington
John F. Engelhardt
John F. Engelhardt University of Iowa

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