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Microbiology

D-Index
68
Citations
16421
World Ranking
2163
National Ranking
903

Overview

Mark T. Heise is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research focuses primarily on the field of Medicine, with significant contributions to Infectious Diseases, Immunology, Public Health, Environmental and Occupational Health, Epidemiology, and Molecular Biology.

The scientist has authored numerous works related to infectious agents and immune responses, particularly focusing on viral infections and SARS-CoV-2. Key topics covered in their body of research include SARS-CoV-2 and COVID-19 research, mosquito-borne diseases and control, viral infections and vectors, interferon and immune responses, influenza virus research studies, COVID-19 clinical research studies, and animal virus infections studies.

They have published extensively in various scientific venues. Frequent publication outlets for their work include:

  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Immunology
  • Journal of Medicinal Chemistry
  • PLoS Pathogens

Their collaborations have been with several frequent co-authors, including:

  • Ralph S. Baric
  • Martin T. Ferris
  • Sharon Taft-Benz
  • Nathaniel J. Moorman
  • Emily A. Madden

Recent notable publications by Mark T. Heise include:

  • β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells (2021, The Journal of Infectious Diseases)
  • Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts (2023, Science Translational Medicine)
  • Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research (2020, Genetics)
  • Vaccine formulations in clinical development for the prevention of severe acute respiratory syndrome coronavirus 2 infection (2020, Advanced Drug Delivery Reviews)
  • Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection (2021, PLoS Pathogens)

Best Publications

  • Chikungunya: a re-emerging virus

    Felicity J Burt;Micheal S Rolph;Nestor E Rulli;Nestor E Rulli;Suresh Mahalingam

  • The genome architecture of the collaborative cross mouse genetic reference population

    Fuad A. Iraqi;Mustafa Mahajne;Yasser Salaymah;Hani Sandovski

  • NLRX1 is a regulator of mitochondrial antiviral immunity

    Chris B. Moore;Daniel T. Bergstralh;Joseph A. Duncan;Yu Lei

  • A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

    Meagan Bolles;Damon Deming;Kristin Michelle Long;Sudhakar Agnihothram

  • Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

    Lisa E. Gralinski;Timothy Patrick Sheahan;Thomas E. Morrison;Vineet D. Menachery;Vineet D. Menachery

  • Severe Acute Respiratory Syndrome Coronavirus ORF6 Antagonizes STAT1 Function by Sequestering Nuclear Import Factors on the Rough Endoplasmic Reticulum/Golgi Membrane

    Matthew Frieman;Boyd Yount;Mark Heise;Sarah A. Kopecky-Bromberg

  • A Mouse-Adapted SARS-Coronavirus Causes Disease and Mortality in BALB/c Mice

    Anjeanette Roberts;Damon Deming;Christopher D. Paddock;Aaron Cheng

  • A Gnotobiotic Mouse Model Demonstrates that Dietary Fiber Protects Against Colorectal Tumorigenesis in a Microbiota- and Butyrate-Dependent Manner

    Dallas R. Donohoe;Darcy Holley;Leonard B. Collins;Stephanie A. Montgomery

  • Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection

    Allison L. Totura;Alan Whitmore;Sudhakar Agnihothram;Alexandra Schäfer

  • Genetic analysis of complex traits in the emerging Collaborative Cross

    David L. Aylor;William Valdar;Wendy Foulds-Mathes;Ryan J. Buus

  • Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance

    Angela L. Rasmussen;Atsushi Okumura;Atsushi Okumura;Martin T Ferris;Richard Green

  • A Mouse Model of Chikungunya Virus–Induced Musculoskeletal Inflammatory Disease : Evidence of Arthritis, Tenosynovitis, Myositis, and Persistence

    Thomas E. Morrison;Lauren Oko;Stephanie A. Montgomery;Alan C. Whitmore

  • Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants

    Damon Deming;Timothy Sheahan;Mark Heise;Boyd Yount

  • Development of a Highly Protective Combination Monoclonal Antibody Therapy against Chikungunya Virus

    Pankaj Pal;Kimberly A. Dowd;James D. Brien;Melissa A. Edeling

  • Unique Signatures of Long Noncoding RNA Expression in Response to Virus Infection and Altered Innate Immune Signaling

    Xinxia Peng;Lisa Gralinski;Christopher D. Armour;Martin T Ferris

  • β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells.

    Shuntai Zhou;Collin S Hill;Sanjay Sarkar;Longping V Tse

  • SARS coronavirus and innate immunity.

    Matthew Frieman;Mark Heise;Ralph Baric

  • Characterization of Ross River Virus Tropism and Virus-Induced Inflammation in a Mouse Model of Viral Arthritis and Myositis

    Thomas E. Morrison;Alan C. Whitmore;Reed S. Shabman;Brett A. Lidbury

  • Dengue Virus Envelope Dimer Epitope Monoclonal Antibodies Isolated from Dengue Patients Are Protective against Zika Virus

    J. A. Swanstrom;Jessica Plante;K. S. Plante;E. F. Young

  • Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.

    Martin T. Ferris;David L. Aylor;Daniel Bottomly;Alan C. Whitmore

  • Short Communication A Mouse Model of Chikungunya Virus-Induced Musculoskeletal Inflammatory Disease Evidence of Arthritis, Tenosynovitis, Myositis, and Persistence

    Thomas E. Morrison;Lauren Oko;Stephanie A. Montgomery;Alan C. Whitmore

Frequent Co-Authors

Ralph S. Baric
Ralph S. Baric University of North Carolina at Chapel Hill
Thomas E. Morrison
Thomas E. Morrison University of Colorado Anschutz Medical Campus
Lisa E. Gralinski
Lisa E. Gralinski University of North Carolina at Chapel Hill
Fernando Pardo-Manuel de Villena
Fernando Pardo-Manuel de Villena University of North Carolina at Chapel Hill
Vineet D. Menachery
Vineet D. Menachery The University of Texas Medical Branch at Galveston
Boyd Yount
Boyd Yount University of North Carolina at Chapel Hill
Daniel N. Streblow
Daniel N. Streblow Oregon Health & Science University
David W. Threadgill
David W. Threadgill Texas A&M University
Matthew B. Frieman
Matthew B. Frieman University of Maryland, Baltimore
Timothy P. Sheahan
Timothy P. Sheahan University of North Carolina at Chapel Hill

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