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Biology and Biochemistry

D-Index
98
Citations
30969
World Ranking
1691
National Ranking
941

Overview

Charles A. Parkos is affiliated with the University of Michigan-Ann Arbor in the United States. Their research spans multiple disciplines with a focus primarily on medicine, biochemistry, genetics, molecular biology, and immunology and microbiology.

The scientist has contributed extensively to fields such as immunology, molecular biology, surgery, immunology and allergy, and neurology. Their work covers a variety of topics that include immune response and inflammation, cell adhesion molecules research, gut microbiota and health, glycosylation and glycoproteins research, Helicobacter pylori-related gastroenterology studies, barrier structure and function studies, and wound healing and treatments.

Charles A. Parkos has published research in several important scientific venues. Frequent publication venues include:

  • The FASEB Journal
  • JCI Insight
  • Gastroenterology
  • Inflammatory Bowel Diseases
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature

Some of the recent papers authored or co-authored by Parkos highlight their research interests and include:

  • Resolvin E1 is a pro-repair molecule that promotes intestinal epithelial wound healing, 2020, Proceedings of the National Academy of Sciences
  • Blocking integrin α4β7-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis, 2020, Journal of Hepatology
  • Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation, 2021, Mucosal Immunology
  • Claudin-23 reshapes epithelial tight junction architecture to regulate barrier function, 2023, Nature Communications
  • Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration, 2020, Molecular Biology of the Cell

Collaboration is a significant aspect of Parkos's research activity. Frequent co-authors include:

  • Asma Nusrat
  • Jennifer Brazil
  • Miguel Quirós
  • Vicky García-Hernández
  • Verónica Azcutia

The body of work by Charles A. Parkos engages strongly with the mechanisms underlying inflammation, cell adhesion in epithelial tissues, and how these relate to intestinal health and repair processes. Their research contributes to understanding complex interactions in immune responses and barrier functions critical to gastrointestinal biology and medicine.

Best Publications

  • Proinflammatory Cytokines Disrupt Epithelial Barrier Function by Apoptosis-Independent Mechanisms

    Matthias Bruewer;Andreas Luegering;Andreas Luegering;Torsten Kucharzik;Torsten Kucharzik;Charles A. Parkos

  • Junction Adhesion Molecule Is a Receptor for Reovirus

    Erik S Barton;J.Craig Forrest;Jodi L Connolly;James D Chappell

  • The role of neutrophils during intestinal inflammation.

    B M Fournier;C A Parkos

  • Human junction adhesion molecule regulates tight junction resealing in epithelia.

    Yuan Liu;Asma Nusrat;Frederick J. Schnell;Titus A. Reaves

  • Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junction proteins

    Torsten Kucharzik;Shaun V. Walsh;Jason Chen;Charles A. Parkos

  • JAM-A regulates permeability and inflammation in the intestine in vivo.

    Mike G. Laukoetter;Porfirio Nava;Winston Y. Lee;Eric A. Severson

  • Tight junctions are membrane microdomains

    A. Nusrat;C.A. Parkos;P. Verkade;C.S. Foley

  • Inflammation and the Intestinal Barrier: Leukocyte–Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair

    Anny Claude Luissint;Charles A. Parkos;Asma Nusrat

  • The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex

    Mary C. Dinauer;Stuart H. Orkin;Stuart H. Orkin;Robin Brown;Robin Brown;Algirdas J. Jesaitis

  • Endocytosis of Epithelial Apical Junctional Proteins by a Clathrin-mediated Pathway into a Unique Storage Compartment

    Andrei I. Ivanov;Asma Nusrat;Charles A. Parkos

  • Interferon-γ induces internalization of epithelial tight junction proteins via a macropinocytosis-like process

    Matthias Bruewer;Markus Utech;Markus Utech;Andrei I. Ivanov;Ann M. Hopkins

  • 5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers.

    James L. Madara;Thomas W. Patapoff;Beth Gillece-Castro;Sean P. Colgan

  • Neutrophil migration across a cultured intestinal epithelium. Dependence on a CD11b/CD18-mediated event and enhanced efficiency in physiological direction.

    C A Parkos;C Delp;M A Arnaout;J L Madara

  • Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b.

    Charles A. Parkos;Mary C. Dinauer;Leslie E. Walker;Rodger A. Allen

  • Mechanism of IFN-γ-induced Endocytosis of Tight Junction Proteins: Myosin II-dependent Vacuolarization of the Apical Plasma Membrane

    Markus Utech;Andrei I. Ivanov;Stanislav N. Samarin;Stanislav N. Samarin;Matthias Bruewer

  • Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins.

    A. Nusrat;C. von Eichel-Streiber;J. R. Turner;J. R. Turner;P. Verkade

  • Cytoskeletal Regulation of Epithelial Barrier Function During Inflammation

    Andrei I. Ivanov;Charles A. Parkos;Asma Nusrat

  • CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation and colitogenic TH17 responses in mice

    Oscar Medina-Contreras;Duke Geem;Oskar Laur;Ifor R Williams

  • Interferon-γ Regulates Intestinal Epithelial Homeostasis through Converging β-Catenin Signaling Pathways

    Porfirio Nava;Stefan Koch;Mike G. Laukoetter;Mike G. Laukoetter;Winston Y. Lee

  • Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1).

    Michael S. Diamond;Ronen Alon;Charles A. Parkos;Mark T. Quinn

Frequent Co-Authors

Asma Nusrat
Asma Nusrat University of Michigan–Ann Arbor
Andrei I. Ivanov
Andrei I. Ivanov Cleveland Clinic
Timothy L. Denning
Timothy L. Denning Georgia Research Alliance
James L. Madara
James L. Madara American Medical Association
Algirdas J. Jesaitis
Algirdas J. Jesaitis Montana State University
Ke Zen
Ke Zen Nanjing University
Francis W. Luscinskas
Francis W. Luscinskas Brigham and Women's Hospital
Eric Peatman
Eric Peatman Auburn University
Mauro Perretti
Mauro Perretti Queen Mary University of London
Terence S. Dermody
Terence S. Dermody University of Pittsburgh

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