World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
84
Citations
27211
World Ranking
914
National Ranking
423

Overview

Francis W. Luscinskas is affiliated with Brigham and Women's Hospital in the United States. Their research primarily spans the fields of Immunology and Microbiology as well as Biochemistry, Genetics and Molecular Biology. Specific subfields include Immunology, Molecular Biology, Cardiology and Cardiovascular Medicine, Immunology and Allergy, and Neurology.

They have contributed to multiple topics particularly centered on immune system function and regulation. These main topics include phagocytosis and immune regulation, interferon and immune responses, inflammasome and immune disorders, T-cell and B-cell immunology, cardiac fibrosis and remodeling, heart failure treatment and management, and signaling pathways in disease.

Luscinskas has published in several scientific venues, prominently appearing in JCI Insight with three publications, as well as in Nature Communications, Journal of Autoimmunity, Mucosal Immunology, and PLoS ONE.

  • Eosinophils improve cardiac function after myocardial infarction, 2020, Nature Communications
  • Endothelial STING controls Tcell transmigration in an IFN-I dependent manner, 2021, JCI Insight
  • Galectin-9 bridges human B cells to vascular endothelium while programming regulatory pathways, 2020, Journal of Autoimmunity
  • Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo, 2020, Mucosal Immunology
  • CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery in EAE, 2021, JCI Insight

Their frequent co-authors include Gail Newton, Marina Anastasiou, Kuljeet Kaur, Sasha Smolgovsky, and Pilar Alcaide, indicating collaboration networks mainly within immunology and related biomedical research sectors.

Best Publications

  • MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions.

    Robert E. Gerszten;Eduardo A. Garcia-Zepeda;Yaw-Chyn Lim;Yaw-Chyn Lim;Masayuki Yoshida

  • Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata

    Filip K. Swirski;Peter Libby;Elena Aikawa;Pilar Alcaide

  • IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1.

    R P Schleimer;S A Sterbinsky;J Kaiser;C A Bickel

  • ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-α-activated vascular endothelium under flow

    Lin Yang;Richard M. Froio;Richard M. Froio;Richard M. Froio;Tracey E. Sciuto;Tracey E. Sciuto;Tracey E. Sciuto;Ann M. Dvorak;Ann M. Dvorak;Ann M. Dvorak

  • KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation.

    Sucharita SenBanerjee;Zhiyong Lin;G. Brandon Atkins;Daniel M. Greif

  • Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules.

    Bruce S. Bochner;Francis W. Luscinskas;Michael A. Gimbrone;Walter Newman

  • Fractalkine Preferentially Mediates Arrest and Migration of CD16+ Monocytes

    Petronela Ancuta;Ravi Rao;Ashlee Moses;Andrew Mehle

  • NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis

    Jonathan D. Brown;Charles Y. Lin;Qiong Duan;Qiong Duan;Gabriel Griffin

  • Endothelial-Dependent Mechanisms of Leukocyte Recruitment to the Vascular Wall

    Ravi M. Rao;Lin Yang;Guillermo Garcia-Cardena;Francis W. Luscinskas

  • Cytokine-activated human endothelial monolayers support enhanced neutrophil transmigration via a mechanism involving both endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1.

    Francis W. Luscinskas;Myron I. Cybulsky;Jeanne Marie Kiely;Christopher S. Peckins

  • Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion.

    O Spertini;F W Luscinskas;G S Kansas;J M Munro

  • Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins

    Francis W. Luscinskas;Geoffrey S. Kansas;Hart Ding;Pilaf Pizcueta

  • Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells

    J. Shen;F. W. Luscinskas;A. Connolly;C. F. Dewey

  • Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase

    Xavier Cullere;Sunil K. Shaw;Lorna Andersson;Junichi Hirahashi

  • The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression

    Margaret A. Read;Andrew S. Neish;Francis W. Luscinskas;Vito J. Palombella

  • IL-17 and TNF-α Sustain Neutrophil Recruitment during Inflammation through Synergistic Effects on Endothelial Activation

    Gabriel K. Griffin;Gail Newton;Margarite L. Tarrio;De Xiu Bu;De Xiu Bu

  • Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium.

    F W Luscinskas;A F Brock;M A Arnaout;M A Gimbrone

  • Apolipoprotein CIII Induces Expression of Vascular Cell Adhesion Molecule-1 in Vascular Endothelial Cells and Increases Adhesion of Monocytic Cells

    Akio Kawakami;Masanori Aikawa;Pilar Alcaide;Francis W. Luscinskas

  • Integrins as dynamic regulators of vascular function.

    Francis W. Luscinskas;Jack Lawler

  • Real-Time Imaging of Vascular Endothelial-Cadherin During Leukocyte Transmigration Across Endothelium

    Sunil K. Shaw;Paul S. Bamba;Brandy N. Perkins;Francis W. Luscinskas

  • Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration.

    J. W. Pierce;M. A. Read;Han Ding;F. W. Luscinskas

Frequent Co-Authors

Michael A. Gimbrone
Michael A. Gimbrone Brigham and Women's Hospital
Andrew H. Lichtman
Andrew H. Lichtman Brigham and Women's Hospital
Tanya N. Mayadas
Tanya N. Mayadas Brigham and Women's Hospital
Charles A. Parkos
Charles A. Parkos University of Michigan–Ann Arbor
Asma Nusrat
Asma Nusrat University of Michigan–Ann Arbor
Thomas F. Tedder
Thomas F. Tedder Duke University
Geoffrey S. Kansas
Geoffrey S. Kansas Northwestern University
Ronen Alon
Ronen Alon Weizmann Institute of Science
Guillermo García-Cardeña
Guillermo García-Cardeña Brigham and Women's Hospital
Masanori Aikawa
Masanori Aikawa Brigham and Women's Hospital

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