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Biology and Biochemistry

D-Index
79
Citations
28875
World Ranking
4237
National Ranking
2071

Overview

William A. Muller is a researcher affiliated with Northwestern University in the United States. Their work spans multiple areas within medicine and biochemistry, genetics, and molecular biology, with a focus on neurology, molecular biology, immunology, and oncology. The scope of their research encompasses neuroinflammation and neurodegeneration mechanisms, cell adhesion molecules, neutrophil and oxidative mechanisms, immune response and inflammation, as well as immune cells in cancer, angiogenesis, and metastasis.

Muller's recent notable publications include:

  • ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer (2021), published in Nature Communications
  • Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro (2020), published in Fluids and Barriers of the CNS
  • Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation (2021), published in Immunity
  • Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma (2023), published in Cell Reports
  • Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer (2023), published in Cancer Discovery

Their frequent coauthors include:

  • David P. Sullivan (28 joint publications)
  • Ayush Batra (14 joint publications)
  • Neil Nadkarni (10 joint publications)
  • Maureen E. Haynes (7 joint publications)
  • Rokana Taftaf (6 joint publications)

Muller's research is often published in venues such as:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature (12 publications)
  • American Journal Of Pathology (8 publications)
  • The FASEB Journal (8 publications)
  • Stroke (6 publications)
  • Cancer Research (4 publications)

Their primary fields of study include medicine and biochemistry, genetics, and molecular biology, while their main subfields are neurology, molecular biology, immunology, immunology and allergy, and oncology. The themes of their research focus on cellular and molecular mechanisms involved in inflammation, immune responses, cancer progression, and brain barrier crossing abilities of immune cells.

Best Publications

  • Endocytosis and the recycling of plasma membrane.

    Ralph M. Steinman;Ira S. Mellman;William A Muller;Zanvil A. Cohn

  • PECAM-1 is required for transendothelial migration of leukocytes.

    William A. Muller;Susan A. Weigl;Xiaohui Deng;David M. Phillips

  • PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily

    Peter J. Newman;Michael C. Berndt;Jack Gorski;Gilbert C. White

  • Differentiation of Phagocytic Monocytes into Lymph Node Dendritic Cells In Vivo

    Gwendalyn J Randolph;Kayo Inaba;Davide F Robbiani;Ralph M Steinman

  • Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.

    William A. Muller

  • Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking

    Gwendalyn J. Randolph;Sylvie Beaulieu;Serge Lebecque;Ralph M. Steinman

  • Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule.

    Steven M. Albelda;William A. Muller;Clayton A. Buck;Peter J. Newman

  • The Abundant NK Cells in Human Secondary Lymphoid Tissues Require Activation to Express Killer Cell Ig-Like Receptors and Become Cytolytic

    Guido Ferlazzo;Dolca Thomas;Shao Lee Lin;Kiera Goodman

  • Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs.

    Guido Ferlazzo;Maggi Pack;Dolca Thomas;Casper Paludan

  • Mechanisms of Leukocyte Transendothelial Migration

    William A. Muller

  • CD99 plays a major role in the migration of monocytes through endothelial junctions.

    Alan R. Schenkel;Zahra Mamdouh;Xia Chen;Ronald M. Liebman

  • Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions.

    G S Duncan;D P Andrew;H Takimoto;H Takimoto;S A Kaufman

  • The Leukotriene C4 Transporter MRP1 Regulates CCL19 (MIP-3β, ELC)–Dependent Mobilization of Dendritic Cells to Lymph Nodes

    Davide F Robbiani;Rick A Finch;Dirk Jäger;William A Muller

  • Locomotion of monocytes on endothelium is a critical step during extravasation.

    Alan R Schenkel;Zahra Mamdouh;William A Muller

  • A HUMAN ENDOTHELIAL CELL-RESTRICTED, EXTERNALLY DISPOSED PLASMALEMMAL PROTEIN ENRICHED IN INTERCELLULAR JUNCTIONS

    W A Muller;C M Ratti;S L McDonnell;Z A Cohn

  • Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability.

    Monica Corada;Fang Liao;Maria Lindgren;Maria Grazia Lampugnani

  • Leukocyte-endothelial cell interactions in the inflammatory response.

    William A Muller

  • Getting leukocytes to the site of inflammation.

    W. A. Muller

  • Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis

    Zahra Mamdouh;Xia Chen;Lynda M. Pierini;Frederick R. Maxfield

  • Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo.

    Steven Bogen;John Pak;Maria Garifallou;Xiaohui Deng

Frequent Co-Authors

Ralph M. Steinman
Ralph M. Steinman Rockefeller University
Suzanne M. Crowe
Suzanne M. Crowe Burnet Institute
Christian Münz
Christian Münz University of Zurich
Zanvil A. Cohn
Zanvil A. Cohn Rockefeller University
Till Strowig
Till Strowig Helmholtz Centre for Infection Research
Anthony Jaworowski
Anthony Jaworowski RMIT University
Peter J. Newman
Peter J. Newman Medical College of Wisconsin
Gwendalyn J. Randolph
Gwendalyn J. Randolph Washington University in St. Louis
Guido Ferlazzo
Guido Ferlazzo University of Messina

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