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Biology and Biochemistry

D-Index
58
Citations
20260
World Ranking
12924
National Ranking
390

Overview

Maria Grazia Lampugnani is affiliated with the Mario Negri Institute for Pharmacological Research in Italy. Their research contributions primarily focus on the field of Medicine with a particular emphasis on Neurology, supported by numerous publications in related subfields such as Molecular Biology, Cell Biology, Immunology, and Cellular and Molecular Neuroscience.

The scientist's work covers several main topics including Vascular Malformations Diagnosis and Treatment, Intracranial Aneurysms: Treatment and Complications, Intracerebral and Subarachnoid Hemorrhage Research, Barrier Structure and Function Studies, Caveolin-1 and cellular processes, Wnt/β-catenin signaling in development and cancer, as well as S100 Proteins and Annexins.

Maria Grazia Lampugnani has published research articles in various scientific venues. Frequent publication sites include Cellular and Molecular Life Sciences and Zenodo (CERN European Organization for Nuclear Research), each with multiple works. Other venues include Circulation Research, eLife, and The Lancet Neurology.

Notable recent papers authored or co-authored by this scientist include:

  • JAM-A Acts via C/EBP-α to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function, 2020, Circulation Research
  • Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution, 2020, eLife
  • Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial, 2022, The Lancet Neurology
  • Propranolol for familial cerebral cavernous malformation (Treat_CCM): study protocol for a randomized controlled pilot trial, 2020, Trials
  • Propranolol Reduces the Development of Lesions and Rescues Barrier Function in Cerebral Cavernous Malformations, 2021, Stroke

Collaborations form a significant part of their research activities. Frequent co-authors include Elisabetta Dejana, Matteo Malinverno, Peetra U. Magnusson, Claudio Maderna, and Galina V. Beznoussenko.

Best Publications

  • Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.

    Peter Carmeliet;Maria Grazia Lampugnani;Lieve Moons;Ferrucio Breviario

  • The role of adherens junctions and VE-cadherin in the control of vascular permeability.

    Elisabetta Dejana;Fabrizio Orsenigo;Maria Grazia Lampugnani

  • Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells

    Sybille Esser;Maria Grazia Lampugnani;Monica Corada;Elisabetta Dejana

  • Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

    Massimiliano Mazzone;Massimiliano Mazzone;Daniela Dettori;Daniela Dettori;Daniela Dettori;Rodrigo Leite de Oliveira;Rodrigo Leite de Oliveira;Sonja Loges;Sonja Loges

  • Vascular endothelial–cadherin is an important determinant of microvascular integrity in vivo

    Monica Corada;Massimo Mariotti;Gavin Thurston;Kelly Smith

  • A novel endothelial-specific membrane protein is a marker of cell-cell contacts.

    M G Lampugnani;M Resnati;M Raiteri;R Pigott

  • The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin).

    M G Lampugnani;M Corada;L Caveda;F Breviario

  • Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments.

    Maria Grazia Lampugnani;Fabrizio Orsenigo;Maria Cristina Gagliani;Carlo Tacchetti

  • Endothelial cell-to-cell junctions.

    Elisabetta Dejana;Monica Corada;Maria Grazia Lampugnani

  • Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, β-catenin, and the phosphatase DEP-1/CD148

    Maria Grazia Lampugnani;Adriana Zanetti;Monica Corada;Takamune Takahashi

  • Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions.

    A Del Maschio;A Zanetti;M Corada;Y Rival

  • EndMT contributes to the onset and progression of cerebral cavernous malformations

    Luigi Maddaluno;Noemi Rudini;Roberto Cuttano;Luca Bravi

  • Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo

    Fabrizio Orsenigo;Costanza Giampietro;Alberto Ferrari;Monica Corada

  • Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability.

    Monica Corada;Fang Liao;Maria Lindgren;Maria Grazia Lampugnani

  • Thrombin-Induced Increase in Endothelial Permeability Is Associated With Changes in Cell-to-Cell Junction Organization

    Marie-Josèphe Rabiet;Jean-Luc Plantier;Yves Rival;Yolande Genoux

  • The role of integrins in the maintenance of endothelial monolayer integrity.

    M G Lampugnani;M Resnati;E Dejana;P C Marchisio

  • Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells.

    M.G. Lampugnani;M. Corada;P. Andriopoulou;S. Esser

  • Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium.

    Vecchi A;Garlanda C;Lampugnani Mg;Resnati M

  • Functional Properties of Human Vascular Endothelial Cadherin (7B4/Cadherin-5), an Endothelium-Specific Cadherin

    F. Breviario;L. Caveda;M. Corada;I. Martin-Padura

  • Vascular Endothelial (VE)-Cadherin: Only an Intercellular Glue?

    Elisabetta Dejana;Gianfranco Bazzoni;Maria Grazia Lampugnani

Frequent Co-Authors

Elisabetta Dejana
Elisabetta Dejana Uppsala University
Pier Carlo Marchisio
Pier Carlo Marchisio Vita-Salute San Raffaele University
Maria Benedetta Donati
Maria Benedetta Donati Catholic University of America
Alberto Mantovani
Alberto Mantovani Humanitas University
Alexander A. Mironov
Alexander A. Mironov University of Manchester
Giulio Cossu
Giulio Cossu University of Manchester
Nadia Polentarutti
Nadia Polentarutti Humanitas University
Francesco Colotta
Francesco Colotta Mario Negri Institute for Pharmacological Research
Maria Cristina Tanzi
Maria Cristina Tanzi Polytechnic University of Milan

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