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Biology and Biochemistry

D-Index
68
Citations
15692
World Ranking
7833
National Ranking
207

Overview

Peter L. Hordijk is affiliated with the University of Amsterdam in the Netherlands. Their research primarily focuses on medicine and biochemistry, genetics, and molecular biology, with a particular emphasis on molecular biology, pulmonary and respiratory medicine, cell biology, immunology and allergy, and genetics.

Their work covers several main topics, including:

  • Cell Adhesion Molecules Research
  • Protein Kinase Regulation and GTPase Signaling
  • Cellular transport and secretion
  • Aortic aneurysm repair treatments
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Aortic Disease and Treatment Approaches

Several recent papers by Peter L. Hordijk demonstrate an ongoing interest in vascular biology, endothelial integrity, and related cellular mechanisms:

  • "Bosutinib prevents vascular leakage by reducing focal adhesion turnover and reinforcing junctional integrity," 2020, Journal of Cell Science
  • "Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation," 2021, Angiogenesis
  • "Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain," 2020, Acta Neuropathologica Communications
  • "The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting," 2020, Cell Reports
  • "The interplay of Rac1 activity, ubiquitination and GDI binding and its consequences for endothelial cell spreading," 2021, PLoS ONE

The scientist has frequently published in several venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Angiogenesis
  • International Journal of Molecular Sciences
  • UNC Libraries

Peter L. Hordijk often collaborates with a core group of coauthors. Frequent collaborators include:

  • Jisca Majolée
  • Fabienne Podieh
  • Jurjan Aman
  • Kak Khee Yeung
  • Thang V. Pham

Best Publications

  • Breaching multiple barriers : Leukocyte motility through venular walls and the interstitium

    Sussan Nourshargh;Peter L. Hordijk;Michael Sixt

  • Regulation of NADPH Oxidases: The Role of Rac Proteins

    Peter L. Hordijk

  • Inhibition of invasion of epithelial cells by Tiam1-Rac signaling.

    Peter L. Hordijk;Jean Paul ten Klooster;Rob A. van der Kammen;Frits Michiels

  • Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts

    E J van Corven;P L Hordijk;R H Medema;J L Bos

  • Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases.

    Janine M. van Gils;Jaap Jan Zwaginga;Jaap Jan Zwaginga;Peter L. Hordijk

  • Expression and localization of NOX2 and NOX4 in primary human endothelial cells

    J.D. Van Buul;M. Fernandez-Borja;E.C. Anthony;P.L. Hordijk

  • Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease.

    Dominik Hartl;Dominik Hartl;Philipp Latzin;Peter Hordijk;Veronica Marcos

  • Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells

    Sandra van Wetering;Jaap D. van Buul;Safira Quik;Frederik P. J. Mul

  • Regulated Membrane Localization of Tiam1, Mediated by the NH2-terminal Pleckstrin Homology Domain, Is Required for Rac-dependent Membrane Ruffling and C-Jun NH2-terminal Kinase Activation

    F Michiels;J C Stam;P L Hordijk;R A van der Kammen

  • Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes.

    Jacqueline Alblas;Laurien Ulfman;Peter Hordijk;Leo Koenderman

  • Targeting and activation of Rac1 are mediated by the exchange factor β-Pix

    Jean Paul ten Klooster;Zahara M. Jaffer;Jonathan Chernoff;Peter L. Hordijk

  • Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.

    J Alblas;E J van Corven;P L Hordijk;G Milligan

  • Protein tyrosine phosphorylation induced by lysophosphatidic acid in rat-1 fibroblasts : evidence that phosphorylation of MAP kinase is mediated by the Gi-p21ras pathway

    P L Hordijk;I Verlaan;E J van Corven;W H Moolenaar

  • Infiltrated Neutrophils Acquire Novel Chemokine Receptor Expression and Chemokine Responsiveness in Chronic Inflammatory Lung Diseases

    Dominik Hartl;Susanne Krauss-Etschmann;Barbara Koller;Peter L. Hordijk

  • Vascular-endothelial-cadherin modulates endothelial monolayer permeability

    Peter L. Hordijk;Eloise Anthony;Frederik P. J. Mul;Ronald Rientsma

  • VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration

    Sandra van Wetering;Nadia van den Berk;Jaap D. van Buul;Frederik P. J. Mul

  • Signaling in Leukocyte Transendothelial Migration

    Magdalena J. Lorenowicz;Mar Fernandez-Borja;Peter L. Hordijk

  • Calcium Signaling Regulates Translocation and Activation of Rac

    Leo S. Price;Michiel Langeslag;Jean Paul ten Klooster;Peter L. Hordijk

  • Growth factor-like effects of lysophosphatidic acid, a novel lipid mediator

    Kees Jalink;Peter L. Hordijk;Wouter H. Moolenaar

  • Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of β1 and β2 integrins

    Paula A. da Costa Martins;Janine M. van Gils;Anita Mol;Peter L. Hordijk

Frequent Co-Authors

Jaap Jan Zwaginga
Jaap Jan Zwaginga Leiden University Medical Center
Dirk Roos
Dirk Roos University of Amsterdam
Dirk Geerts
Dirk Geerts University of Amsterdam
Wouter H. Moolenaar
Wouter H. Moolenaar Antoni van Leeuwenhoek Hospital
Jan Voorberg
Jan Voorberg University of Amsterdam
John G. Collard
John G. Collard Antoni van Leeuwenhoek Hospital
Theodorus W. J. Gadella
Theodorus W. J. Gadella University of Amsterdam
André M. Deelder
André M. Deelder Leiden University Medical Center
Kees Jalink
Kees Jalink Antoni van Leeuwenhoek Hospital
Taco W. Kuijpers
Taco W. Kuijpers University of Amsterdam

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