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Biology and Biochemistry

D-Index
66
Citations
18056
World Ranking
8563
National Ranking
225

Overview

Kees Jalink is affiliated with the Antoni van Leeuwenhoek Hospital in the Netherlands. Their research spans primarily the fields of Biochemistry, Genetics and Molecular Biology, with significant focus on Molecular Biology, Biophysics, Oncology, Genetics, and Cell Biology.

Their recent publications cover a range of topics and journals, reflecting active engagement in diverse molecular and cellular biological investigations. Representative papers include:

  • Dynamic FRET-FLIM based screening of signal transduction pathways, 2021, Scientific Reports
  • FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks, 2023, Science Advances
  • Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation, 2020, Journal of Cell Science
  • A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing, 2022, Nature Communications
  • SRBD1, a highly conserved gene required for chromosome individualization, 2025, Cell Reports

Frequent coauthors collaborating with Kees Jalink include:

  • Bram van den Broek
  • Jeffrey Klarenbeek
  • Sravasti Mukherjee
  • Rolf Harkes
  • Olga Kukk

Their work is published in a variety of venues, among which the most recurrent are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • OPAL (Open@LaTrobe) (La Trobe University)
  • Scientific Reports
  • Science Advances

Kees Jalink's research focuses on several main topics, including:

  • Receptor Mechanisms and Signaling
  • Phosphodiesterase function and regulation
  • Advanced Fluorescence Microscopy Techniques
  • Retinal Development and Disorders
  • Cell Image Analysis Techniques
  • Bioluminescence and chemiluminescence research
  • DNA Repair Mechanisms

Best Publications

  • Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

    Emile J. van Corven;Alida Groenink;Kees Jalink;Thomas Eichholtz

  • The bioactive phospholipid lysophosphatidic acid is released from activated platelets.

    T Eichholtz;K Jalink;I Fahrenfort;W H Moolenaar

  • Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

    K Jalink;E J van Corven;T Hengeveld;N Morii

  • REV7 counteracts DNA double-strand break resection and affects PARP inhibition

    Guotai Xu;J. Ross Chapman;Inger Brandsma;Jingsong Yuan

  • Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator.

    Bas Ponsioen;Jun Zhao;Jurgen Riedl;Fried Zwartkruis

  • Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells

    Jop Kind;Jop Kind;Ludo Pagie;Sandra S. de Vries;Leila Nahidiazar

  • The Drosophila light-activated conductance is composed of the two channels TRP and TRPL.

    Barbara A Niemeyer;Emiko Suzuki;Kristin Scott;Kees Jalink

  • TRPM7, a novel regulator of actomyosin contractility and cell adhesion

    Kristopher Clark;Michiel Langeslag;Bart van Leeuwen;Leonie Ran

  • Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I.

    Eric Reits;Alexander Griekspoor;Joost Neijssen;Tom Groothuis

  • Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent

    Felicity M. Davis;Iman Azimi;Richard A. Faville;Amelia A. Peters

  • Bright cyan fluorescent protein variants identified by fluorescence lifetime screening

    Joachim Goedhart;Laura van Weeren;Mark A Hink;Norbert O E Vischer

  • Tamoxifen resistance by a conformational arrest of the estrogen receptor α after PKA activation in breast cancer

    Rob Michalides;Alexander Griekspoor;Astrid Balkenende;Desiree Verwoerd

  • Fourth-Generation Epac-Based FRET Sensors for cAMP Feature Exceptional Brightness, Photostability and Dynamic Range: Characterization of Dedicated Sensors for FLIM, for Ratiometry and with High Affinity

    Jeffrey Klarenbeek;Joachim Goedhart;Aernoud van Batenburg;Daniella Groenewald

  • Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2(+)-mobilizing stimulus for fibroblasts. Evidence for an extracellular site of action.

    K Jalink;E J van Corven;W H Moolenaar

  • Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin.

    E J van Corven;A van Rijswijk;K Jalink;R L van der Bend

  • Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor

    F R Postma;K Jalink;T Hengeveld;W H Moolenaar

  • Gold-Enhanced Biomolecular Surface Imaging of Cells and Tissue by SIMS and MALDI Mass Spectrometry

    A. F. Maarten Altelaar;Ivo Klinkert;Kees Jalink;Robert P. J. de Lange

  • Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: similarity to thrombin action

    Kees Jalink;Thomas Eichholtz;Friso R. Postma;J. van Corven

  • Monitoring agonist-induced phospholipase C activation in live cells by fluorescence resonance energy transfer.

    Jose van der Wal;Ron Habets;Péter Várnai;Tamas Balla

  • InsP3 Receptor Is Essential for Growth and Differentiation but Not for Vision in Drosophila

    Jairaj K Acharya;Kees Jalink;Robert W Hardy;Volker Hartenstein

Frequent Co-Authors

Wouter H. Moolenaar
Wouter H. Moolenaar Antoni van Leeuwenhoek Hospital
Jacco van Rheenen
Jacco van Rheenen Antoni van Leeuwenhoek Hospital
Anastassis Perrakis
Anastassis Perrakis Antoni van Leeuwenhoek Hospital
Arnoud Sonnenberg
Arnoud Sonnenberg Antoni van Leeuwenhoek Hospital
Jacques Neefjes
Jacques Neefjes Leiden University Medical Center
Hans Janssen
Hans Janssen KU Leuven
Johannes L. Bos
Johannes L. Bos Utrecht University
Theodorus W. J. Gadella
Theodorus W. J. Gadella University of Amsterdam
René H. Medema
René H. Medema Princess Máxima Center
Nullin Divecha
Nullin Divecha University of Southampton

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