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D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
16904
World Ranking
11767
National Ranking
303

Overview

Jacco van Rheenen is affiliated with the Antoni van Leeuwenhoek Hospital in the Netherlands. The research focuses predominantly on cancer biology, particularly mechanisms underlying cancer cell behavior and metastasis, as well as cellular and molecular pathways involved in tumor progression.

The scientist's recent publications include:

  • Distinct contributions of partial and full EMT to breast cancer malignancy, 2021, Developmental Cell
  • Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer, 2020, Cell Stem Cell
  • PHGDH heterogeneity potentiates cancer cell dissemination and metastasis, 2022, Nature
  • A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA, 2020, Nature Communications
  • Long-distance modulation of bystander tumor cells by CD8+ T-cell-secreted IFN-γ, 2020, Nature Cancer

Frequent co-authors collaborating with Jacco van Rheenen include:

  • Colinda L. G. J. Scheele
  • Laura Bornes
  • Jos Jonkers
  • Hendrik A. Messal
  • Jelle Wesseling

Research publications are often found in established venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nature
  • Developmental Cell
  • Cancer Research

The main fields of study covered in van Rheenen's work are Biochemistry, Genetics and Molecular Biology, and Medicine, with a strong emphasis on the following subfields:

  • Molecular Biology
  • Oncology
  • Cell Biology
  • Cancer Research
  • Genetics

The scientist's research topics address key areas related to cancer and cellular biology, including:

  • Cancer Cells and Metastasis
  • Cellular Mechanics and Interactions
  • Cancer Genomics and Diagnostics
  • Hippo pathway signaling and YAP/TAZ
  • Single-cell and spatial transcriptomics
  • Cancer, Hypoxia, and Metabolism
  • Glioma Diagnosis and Treatment

Best Publications

  • Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

    Hugo J. Snippert;Laurens G. van der Flier;Toshiro Sato;Johan H. van Es

  • In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

    Anoek Zomer;Carrie Maynard;Frederik Johannes Verweij;Alwin Kamermans

  • Collagen-based cell migration models in vitro and in vivo

    Katarina Wolf;Stephanie Alexander;Vivien Schacht;Lisa M. Coussens

  • Intestinal crypt homeostasis revealed at single stem cell level by in vivo live-imaging

    Laila Ritsma;Saskia I J Ellenbroek;Anoek Zomer;Hugo J Snippert

  • Intravital imaging of metastatic behavior through a Mammary Imaging Window

    Dmitriy Kedrin;Bojana Gligorijevic;Jeffrey Wyckoff;Vladislav V Verkhusha

  • Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation

    Matthew Oser;Hideki Yamaguchi;Hideki Yamaguchi;Christopher C. Mader;J.J. Bravo-Cordero

  • Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases

    Sophia Frentzas;Sophia Frentzas;Eve Simoneau;Victoria L. Bridgeman;Peter B. Vermeulen

  • Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling

    Frederik Johannes Verweij;Frederik Johannes Verweij;Frederik Johannes Verweij;Maarten P. Bebelman;Maarten P. Bebelman;Connie R. Jimenez;Juan J. Garcia-Vallejo

  • Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

    Evelyne Beerling;Daniëlle Seinstra;Elzo de Wit;Elzo de Wit;Lennart Kester

  • Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen

    Silvia Ariotti;Joost B. Beltman;Grzegorz Chodaczek;Mirjam E. Hoekstra

  • Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.

    Nobuo Sasaki;Norman Sachs;Kay Wiebrands;Saskia I. J. Ellenbroek

  • EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells

    Jacco Van Rheenen;Xiaoyan Song;Wies Van Roosmalen;Michael Cammer

  • Distinct contributions of partial and full EMT to breast cancer malignancy.

    Fabiana Lüönd;Nami Sugiyama;Ruben Bill;Laura Bornes

  • Integrins control motile strategy through a Rho-cofilin pathway.

    Erik H.J. Danen;Jacco van Rheenen;Willeke Franken;Stephan Huveneers

  • Surgical implantation of an abdominal imaging window for intravital microscopy.

    Laila Ritsma;Ernst J A Steller;Saskia I J Ellenbroek;Onno Kranenburg

  • Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

    Arianna Fumagalli;Koen C. Oost;Koen C. Oost;Lennart Kester;Jessica Morgner

  • Correcting confocal acquisition to optimize imaging of fluorescence resonance energy transfer by sensitized emission.

    Jacco van Rheenen;Michiel Langeslag;Kees Jalink

  • A Versatile Toolkit to Produce Sensitive FRET Biosensors to Visualize Signaling in Time and Space

    Rafael D. Fritz;Michel Letzelter;Andreas Reimann;Katrin Martin

  • Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

    Arianna Fumagalli;Arianna Fumagalli;Jarno Drost;Jarno Drost;Saskia J E Suijkerbuijk;Saskia J E Suijkerbuijk;Ruben van Boxtel

  • Cell Motility and Cytoskeletal Regulation in Invasion and Metastasis

    Dmitriy Kedrin;Jacco van Rheenen;Lorena Hernandez;John Condeelis

Frequent Co-Authors

Kees Jalink
Kees Jalink Antoni van Leeuwenhoek Hospital
John S. Condeelis
John S. Condeelis Albert Einstein College of Medicine
Benjamin D. Simons
Benjamin D. Simons University of Cambridge
Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Onno Kranenburg
Onno Kranenburg Utrecht University
Owen J. Sansom
Owen J. Sansom University of Glasgow
Ton N. M. Schumacher
Ton N. M. Schumacher Antoni van Leeuwenhoek Hospital
Arnoud Sonnenberg
Arnoud Sonnenberg Antoni van Leeuwenhoek Hospital
Jeffrey E. Segall
Jeffrey E. Segall Albert Einstein College of Medicine
Hans Janssen
Hans Janssen KU Leuven

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