World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
15932
World Ranking
7822
National Ranking
206

Overview

Onno Kranenburg is affiliated with Utrecht University in the Netherlands and has contributed extensively to medical research, focusing primarily on oncology and cancer biology. Their work centers on cancer cells and metastasis, colorectal cancer treatments and studies, and cancer genomics and diagnostics. Additional topics include genetic factors in colorectal cancer, intraperitoneal and appendiceal malignancies, hepatocellular carcinoma treatment and prognosis, and cancer immunotherapy and biomarkers.

Their research spans fields of medicine and biochemistry, genetics, and molecular biology, with a substantial emphasis on oncology, molecular biology, surgery, cancer research, and pathology and forensic medicine as subfields of study.

They have published in various scientific venues, with frequent contributions to:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • British Journal of Cancer
  • Cancers
  • British journal of surgery

Onno Kranenburg has collaborated regularly with several researchers, including:

  • Inne H.M. Borel Rinkes
  • Jeroen Hagendoorn
  • Miriam Koopman
  • Jeanine M.L. Roodhart
  • Sjoerd G. Elias

The following are some of their recent publications with year of publication and venue:

  • Patient-derived organoids as a predictive biomarker for treatment response in cancer patients (2021), npj Precision Oncology
  • Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer (2021), Cell stem cell
  • Organoid models of gastrointestinal cancers in basic and translational research (2020), Nature Reviews Gastroenterology & Hepatology
  • Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases (2020), Nature Genetics
  • Molecular characterization of colorectal cancer related peritoneal metastatic disease (2022), Nature Communications

Best Publications

  • Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors.

    Frits J. Fallaux;Onno Kranenburg;Steve J. Cramer;Ada Houweling

  • Lysophosphatidic acid: G-protein signalling and cellular responses

    Wouter H Moolenaar;Onno Kranenburg;Friso R Postma;Gerben Cm Zondag

  • Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells

    Masaya Hirose;Toshimasa Ishizaki;Naoki Watanabe;Masayoshi Uehata

  • The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

    Frank N. van Leeuwen;Hendrie E.T. Kain;Rob A. van der Kammen;Frits Michiels

  • Activation of RhoA by Lysophosphatidic Acid and Gα12/13 Subunits in Neuronal Cells: Induction of Neurite Retraction

    Onno Kranenburg;Mieke Poland;Francis P. G. van Horck;David Drechsel

  • Glycation Induces Formation of Amyloid Cross-β Structure in Albumin

    Barend Bouma;Loes M.J. Kroon-Batenburg;Ya-Ping Wu;Bettina Brünjes

  • Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

    Else Driehuis;Arne van Hoeck;Kat Moore;Sigrid Kolders

  • The KRAS oncogene: past, present, and future.

    Onno Kranenburg

  • Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy

    Else Driehuis;Sigrid Kolders;Sacha Spelier;Kadi Lõhmussaar

  • Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade.

    Julian Andreev;Maria L. Galisteo;Onno Kranenburg;Susan K. Logan

  • Surgical implantation of an abdominal imaging window for intravital microscopy.

    Laila Ritsma;Ernst J A Steller;Saskia I J Ellenbroek;Onno Kranenburg

  • Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists.

    Onno Kranenburg;Wouter H Moolenaar

  • Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules.

    Francis P.G. van Horck;M. Reza Ahmadian;Lars C. Haeusler;Wouter H. Moolenaar

  • Dynamin Is Required for the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase

    Onno Kranenburg;Ingrid Verlaan;Wouter H. Moolenaar

  • Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology.

    Martijn F.B.G. Gebbink;Onno Kranenburg;Mieke Poland;Francis P.G. van Horck

  • Mouse and human urothelial cancer organoids: A tool for bladder cancer research

    Jasper Mullenders;Jasper Mullenders;Evelien de Jongh;Evelien de Jongh;Anneta Brousali;Mieke Roosen;Mieke Roosen

  • SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer

    Thomas T. Vellinga;Tijana Borovski;Vincent C.J. de Boer;Szabolcs Fatrai

  • Dissociation of LPA-induced cytoskeletal contraction from stress fiber formation by differential localization of RhoA

    Onno Kranenburg;Mieke Poland;Martijn Gebbink;Lauran Oomen

  • Stimulation of angiogenesis by Ras proteins.

    Onno Kranenburg;Martijn F.B.G. Gebbink;Emile E. Voest

  • Intravital Microscopy Through an Abdominal Imaging Window Reveals a Pre-Micrometastasis Stage During Liver Metastasis

    Laila Ritsma;Ernst J. A. Steller;Evelyne Beerling;Cindy J. M. Loomans

Frequent Co-Authors

Emile E. Voest
Emile E. Voest Antoni van Leeuwenhoek Hospital
Paul J. van Diest
Paul J. van Diest Utrecht University
Wouter H. Moolenaar
Wouter H. Moolenaar Antoni van Leeuwenhoek Hospital
Rob C. Hoeben
Rob C. Hoeben Leiden University Medical Center
Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Ignace H. J. T. de Hingh
Ignace H. J. T. de Hingh Maastricht University
Cornelis J. A. Punt
Cornelis J. A. Punt University of Amsterdam
Jan Koster
Jan Koster University of Amsterdam
Jan Paul Medema
Jan Paul Medema University of Amsterdam
Jacco van Rheenen
Jacco van Rheenen Antoni van Leeuwenhoek Hospital

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