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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
90
Citations
57613
World Ranking
2377
National Ranking
58

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award

Overview

Jan Paul Medema is affiliated with the University of Amsterdam in the Netherlands. Their academic work primarily focuses on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular concentration in oncology and related subfields.

Their research spans key areas such as oncology, molecular biology, pathology and forensic medicine, cancer research, and surgery. The scientist's main topics of interest include genetic factors in colorectal cancer, colorectal cancer treatments and studies, cancer cells and metastasis, pancreatic and hepatic oncology research, cancer genomics and diagnostics, colorectal cancer surgical treatments, and digestive system health.

Medema's publication record is extensive, with frequent contributions to various scientific journals. The main venues for their work include:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancers
  • BMC Cancer
  • Research Square (Research Square)

They collaborate regularly with several co-authors such as Jan Köster, Maarten F. Bijlsma, Louis Vermeulen, Arezo Torang, and Hanneke W.M. van Laarhoven.

Recent notable papers authored by or involving Jan Paul Medema include:

  • The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis, 2021, Cancers
  • Apc-mutant cells act as supercompetitors in intestinal tumour initiation, 2021, Nature
  • BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy, 2020, APOPTOSIS
  • Molecular characterization of colorectal cancer related peritoneal metastatic disease, 2022, Nature Communications
  • PI3K-driven HER2 expression is a potential therapeutic target in colorectal cancer stem cells, 2021, Gut

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • The consensus molecular subtypes of colorectal cancer

    Justin Guinney;Rodrigo Dienstmann;Rodrigo Dienstmann;Xingwu Wang;Xingwu Wang;Aurélien De Reyniès

  • Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

    Louis Vermeulen;Felipe De Sousa E Melo;Maartje van der Heijden;Kate Cameron

  • FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

    Jan Paul Medema;Carsten Scaffidi;Frank C. Kischkel;Andrej Shevchenko

  • Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.

    Matilde Todaro;Mileidys Perez Alea;Anna B. Di Stefano;Patrizia Cammareri

  • Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

    L. Galluzzi;J. M. Bravo-San Pedro;I. Vitale;S. A. Aaronson

  • Sequential cancer mutations in cultured human intestinal stem cells

    Jarno Drost;Richard H. van Jaarsveld;Bas Ponsioen;Cheryl Zimberlin

  • Betulin Is a Potent Anti-Tumor Agent that Is Enhanced by Cholesterol

    Franziska B. Mullauer;Jan H. Kessler;Jan H. Kessler;Jan Paul Medema

  • Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity

    L. Vermeulen;M. Todaro;F. de Sousa Mello;M. R. Sprick

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Cancer stem cells: The challenges ahead

    Jan Paul Medema

  • Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

    Felipe De Sousa E Melo;Xin Wang;Marnix Jansen;Evelyn Fessler

  • Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

    L. Galluzzi;L. Galluzzi;L. Galluzzi;S. A. Aaronson;J. Abrams;E. S. Alnemri

  • Intra-tumor heterogeneity from a cancer stem cell perspective

    Pramudita R. Prasetyanti;Jan Paul Medema

  • Cancer Stem Cell Niche: The Place to Be

    Tijana Borovski;Felipe De Sousa E Melo;Louis Vermeulen;Jan Paul Medema

  • Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

    Jan Paul Medema;Louis Vermeulen

  • Colon cancer stem cells: promise of targeted therapy.

    Matilde Todaro;Maria Giovanna Francipane;Jan Paul Medema;Giorgio Stassi

  • FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.

    Carsten Scaffidi;Jan Paul Medema;Peter H. Krammer;Marcus E. Peter

  • The developing cancer stem-cell model: clinical challenges and opportunities

    Louis Vermeulen;Felipe de Sousa e Melo;Dick J Richel;Jan Paul Medema

Frequent Co-Authors

Michael Hahne
Michael Hahne Centre national de la recherche scientifique, CNRS
Giorgio Stassi
Giorgio Stassi University of Palermo
Matilde Todaro
Matilde Todaro University of Palermo
Marcus E. Peter
Marcus E. Peter Northwestern University
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Boris Zhivotovsky
Boris Zhivotovsky Karolinska Institute
Oliver Kepp
Oliver Kepp Institut Gustave Roussy
Rienk Offringa
Rienk Offringa German Cancer Research Center
Lorenzo Galluzzi
Lorenzo Galluzzi Cornell University

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