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Immunology

D-Index
84
Citations
28656
World Ranking
1355
National Ranking
86

Medicine

D-Index
84
Citations
28656
World Ranking
15001
National Ranking
792

Overview

Rienk Offringa is affiliated with the German Cancer Research Center in Germany. Their research work spans several intersecting fields, primarily within medicine, immunology and microbiology, and biochemistry, genetics and molecular biology.

The scientist's main fields of study include:

  • Medicine
  • Immunology and Microbiology
  • Biochemistry, Genetics and Molecular Biology

Within these areas, they focus on several subfields such as oncology, immunology, molecular biology, cancer research, and pathology and forensic medicine.

  • Oncology
  • Immunology
  • Molecular Biology
  • Cancer Research
  • Pathology and Forensic Medicine

Major topics within Rienk Offringa's work cover a range of important biomedical research themes:

  • CAR-T cell therapy research
  • Cancer Immunotherapy and Biomarkers
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Immune cells in cancer
  • Pancreatic and Hepatic Oncology Research
  • Immunotherapy and Immune Responses

The scientist has published research articles in several prominent venues. Frequent publication outlets include:

  • Cancer Research
  • Journal for ImmunoTherapy of Cancer
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Regular and Young Investigator Award Abstracts
  • Scientific Reports

Rienk Offringa collaborates regularly with several researchers, including Michael Volkmar, Isabel Poschke, Daniel Baumann, Zibo Meng, and Stefan Zens.

  • Michael Volkmar
  • Isabel Poschke
  • Daniel Baumann
  • Zibo Meng
  • Stefan Zens

Selected recent papers featuring or authored by Rienk Offringa include:

  • The expanding role for small molecules in immuno-oncology, 2022, Nature Reviews Drug Discovery
  • The m6A-Related mRNA Signature Predicts the Prognosis of Pancreatic Cancer Patients, 2020, Molecular Therapy - Oncolytics
  • The Outcome of Ex Vivo TIL Expansion Is Highly Influenced by Spatial Heterogeneity of the Tumor T-Cell Repertoire and Differences in Intrinsic In Vitro Growth Capacity between T-Cell Clones, 2020, Clinical Cancer Research
  • Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy, 2020, Nature Communications
  • Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy, 2023, Journal for ImmunoTherapy of Cancer

Best Publications

  • T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

    S. P. Schoenberger;R. E. M. Toes;E. I. H. Van Der Voort;R. Offringa

  • Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses.

    R. P.M. Sutmuller;L. M. Van Duivenvoorde;A. Van Elsas;T. N.M. Schumacher

  • Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

    Gemma G Kenter;Marij J P Welters;A Rob P M Valentijn;Margriet J G Lowik

  • CD4 T cells and their role in antitumor immune responses.

    René E.M. Toes;Ferry Ossendorp;Rienk Offringa;Cornelis J.M. Melief

  • Established Human Papillomavirus Type 16-Expressing Tumors Are Effectively Eradicated Following Vaccination with Long Peptides

    Sander Zwaveling;Sandra C. Ferreira Mota;Jan Nouta;Mark Johnson

  • CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy.

    Diehl L;den Boer At;Schoenberger Sp;van der Voort Ei

  • The minor histocompatibility antigen HA-1 : A diallelic gene with a single amino acid polymorphism

    J.M.M. den Haan;L.M. Meadows;W. Wang;J. Pool

  • High Number of Intraepithelial CD8+ Tumor-Infiltrating Lymphocytes Is Associated with the Absence of Lymph Node Metastases in Patients with Large Early-Stage Cervical Cancer

    Sytse J. Piersma;Ekaterina S. Jordanova;Mariëtte I.E. van Poelgeest;Kitty M.C. Kwappenberg

  • Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine Comparison of Prophylaxis and Therapy

    A. Van Elsas;R. P M Sutmuller;A. A. Hurwitz;J. Ziskin

  • Induction of tumor-specific CD4+ and CD8+ T-cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine.

    Marij J P Welters;Gemma G Kenter;Sytse J Piersma;Annelies P G Vloon

  • Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

    J. P. Medema;J. de Jong;L. T. C. Peltenburg;E. M. E. Verdegaal

  • Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein.

    J. P. Medema;J. De Jong;T. Van Hall;C. J. M. Melief

  • Phase I immunotherapeutic trial with long peptides spanning the E6 and E7 sequences of high-risk human papillomavirus 16 in end-stage cervical cancer patients shows low toxicity and robust immunogenicity

    Gemma G Kenter;Marij J P Welters;A Rob P M Valentijn;Margriet J G Lowik

  • CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis.

    Mary E. Morgan;Roger P. M. Sutmuller;Hendrik J. Witteveen;Leonie M. van Duivenvoorde

  • Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction.

    R. E. M. Toes;R. Offringa;R. J. J. Blom;C. J. M. Melief

  • Human Papillomavirus Type 16-Positive Cervical Cancer Is Associated with Impaired CD4+ T-Cell Immunity against Early Antigens E2 and E6

    Annemieke de Jong;Mariëtte I. E. van Poelgeest;Jeanette M. van der Hulst;Jan Wouter Drijfhout

  • Eradication of adenovirus E1-induced tumors by E1A-specific cytotoxic T lymphocytes.

    W.Martin Kast;Rienk Offringa;Peter J. Peters;Arie C. Voordouw

  • CD8+ CTL Priming by Exact Peptide Epitopes in Incomplete Freund’s Adjuvant Induces a Vanishing CTL Response, whereas Long Peptides Induce Sustained CTL Reactivity

    Martijn S. Bijker;Susan J. F. van den Eeden;Kees L. Franken;Cornelis J. M. Melief

  • Efficient Identification of Novel HLA-A * 0201-presented Cytotoxic T Lymphocyte Epitopes in the Widely Expressed Tumor Antigen PRAME by Proteasome-mediated Digestion Analysis

    Jan H. Kessler;Nico J. Beekman;Sandra A. Bres-Vloemans;Pauline Verdijk

  • CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity.

    Geertje J. D. van Mierlo;Annemieke Th. den Boer;Jan Paul Medema;Ellen I. H. van der Voort

Frequent Co-Authors

Cornelis J. M. Melief
Cornelis J. M. Melief ISA Pharmaceuticals (Netherlands)
Sjoerd H. van der Burg
Sjoerd H. van der Burg Leiden University Medical Center
René E. M. Toes
René E. M. Toes Leiden University Medical Center
Jan W. Drijfhout
Jan W. Drijfhout Leiden University Medical Center
Gemma G. Kenter
Gemma G. Kenter Vrije Universiteit Amsterdam
Ferry Ossendorp
Ferry Ossendorp Leiden University Medical Center
Kees L. M. C. Franken
Kees L. M. C. Franken Leiden University Medical Center
Gert Jan Fleuren
Gert Jan Fleuren Leiden University Medical Center
Marij J. P. Welters
Marij J. P. Welters Leiden University Medical Center
Stephen P. Schoenberger
Stephen P. Schoenberger La Jolla Institute For Allergy & Immunology

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