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Immunology

D-Index
68
Citations
11689
World Ranking
2633
National Ranking
102

Overview

Kees L. M. C. Franken is affiliated with Leiden University Medical Center in the Netherlands. Their research spans several fields within medicine, focusing notably on immunology and microbiology.

Their work encompasses various subfields including immunology, infectious diseases, epidemiology, oncology, and molecular biology. The main topics they have contributed to include tuberculosis research and epidemiology, immune cell function and interaction, immunotherapy and immune responses, T-cell and B-cell immunology, Mycobacterium research and diagnosis, vaccines and immunoinformatics approaches, as well as cancer immunotherapy and biomarkers.

Frequent publication venues for their research include:

  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Immunology
  • npj Vaccines
  • SSRN Electronic Journal

Some of their recent papers are listed below:

  • "RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response" (2020) published in Scientific Reports
  • "T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection" (2023) published in Nature Medicine
  • "A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection" (2022) published in Nature Communications
  • "IL-6 signaling in macrophages is required for immunotherapy-driven regression of tumors" (2021) published in Journal for ImmunoTherapy of Cancer
  • "Cell-Mediated Immune Responses to in vivo-Expressed and Stage-Specific Mycobacterium tuberculosis Antigens in Latent and Active Tuberculosis Across Different Age Groups" (2020) published in Frontiers in Immunology

Their frequent co-authors include:

  • Tom H. M. Ottenhoff (27 collaborations)
  • Simone A. Joosten (14 collaborations)
  • Krista E. van Meijgaarden (13 collaborations)
  • Annemieke Geluk (10 collaborations)
  • Thomas J. Scriba (8 collaborations)

Kees L. M. C. Franken's work covers a significant volume of publications, with 63 contributions classified under Medicine and 57 under Immunology and Microbiology. Their research contributions focus substantially on immune mechanisms related to infectious diseases such as tuberculosis, as well as on immune responses in oncology and vaccine development.

Best Publications

  • Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

    J. P. Medema;J. de Jong;L. T. C. Peltenburg;E. M. E. Verdegaal

  • CD8+ CTL Priming by Exact Peptide Epitopes in Incomplete Freund’s Adjuvant Induces a Vanishing CTL Response, whereas Long Peptides Induce Sustained CTL Reactivity

    Martijn S. Bijker;Susan J. F. van den Eeden;Kees L. Franken;Cornelis J. M. Melief

  • Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis.

    Eliane M.S. Leyten;May Young Lin;Kees L.M.C. Franken;Annemieke H. Friggen

  • Purification of his-tagged proteins by immobilized chelate affinity chromatography: the benefits from the use of organic solvent.

    Kees L.M.C. Franken;Hoebert S. Hiemstra;Krista E. van Meijgaarden;Yanri Subronto

  • Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses

    Marij J. P. Welters;Gemma G. Kenter;Peggy J. de Vos van Steenwijk;Margriet J. G. Löwik

  • Frequent display of human papillomavirus type 16 E6-specific memory t-Helper cells in the healthy population as witness of previous viral encounter.

    Marij J. P. Welters;Annemieke de Jong;Susan J. F. van den Eeden;Jeanette M. van der Hulst

  • Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation

    Martijn S. Bijker;Susan J. F. van den Eeden;Kees L. Franken;Cornelis J. M. Melief

  • Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation.

    Rodney A. Rosalia;Esther D. Quakkelaar;Anke Redeker;Selina Khan

  • Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase

    Hoebert S. Hiemstra;Nanette C. Schloot;Peter A. van Veelen;Sabine J. M. Willemen

  • Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis.

    Maytal Bivas-Benita;Krista E. van Meijgaarden;Kees L.M.C. Franken;Hans E. Junginger

  • Natural T-helper immunity against human papillomavirus type 16 (HPV16) E7-derived peptide epitopes in patients with HPV16-positive cervical lesions: identification of 3 human leukocyte antigen class II-restricted epitopes.

    Sjoerd H. van der Burg;Maaike E. Ressing;Kitty M.C. Kwappenberg;Annemieke de Jong

  • Simultaneous Detection of Circulating Autoreactive CD8 + T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers

    Jurjen H. Velthuis;Wendy W. Unger;Joana R.F. Abreu;Gaby Duinkerken;Gaby Duinkerken

  • Identification of Major Epitopes of Mycobacterium tuberculosis AG85B That Are Recognized by HLA-A*0201-Restricted CD8+ T Cells in HLA-Transgenic Mice and Humans

    A. Geluk;K. E. van Meijgaarden;K. L. M. C. Franken;J. W. Drijfhout

  • Frequent Detection of Human Papillomavirus 16 E2-specific T-helper Immunity in Healthy Subjects

    Annemieke de Jong;Sjoerd H. van der Burg;Kitty M. C. Kwappenberg;Jeanette M. van der Hulst

  • Immunization with Human Papillomavirus Type 16 (HPV16) Oncoprotein-loaded Dendritic Cells as well as Protein in Adjuvant Induces MHC Class I-restricted Protection to HPV16-induced Tumor Cells

    M. L. H. De Bruijn;D. H. Schuurhuis;M. P. M. Vierboom;H. Vermeulen

  • Evaluation of vaccines in the EU TB vaccine cluster using a guinea pig aerosol infection model of tuberculosis

    Ann Williams;Graham J. Hatch;Simon O. Clark;Karen E. Gooch

  • Immunogenicity of Eight Dormancy Regulon-Encoded Proteins of Mycobacterium tuberculosis in DNA-Vaccinated and Tuberculosis-Infected Mice

    Virginie Roupie;Marta Romano;Lei Zhang;Hannelie Korf

  • Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants

    Thorbald van Hall;Elisabeth Z Wolpert;Peter van Veelen;Sandra Laban

  • Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa.

    Gillian F. Black;Bonnie A. Thiel;Martin O. Ota;Shreemanta K. Parida

  • Identification and characterization of the ESAT-6 homologue of Mycobacterium leprae and T-cell cross-reactivity with Mycobacterium tuberculosis.

    Annemieke Geluk;Krista E. van Meijgaarden;Kees L. M. C. Franken;Yanri W. Subronto

Frequent Co-Authors

Tom H. M. Ottenhoff
Tom H. M. Ottenhoff Leiden University Medical Center
Annemieke Geluk
Annemieke Geluk Leiden University Medical Center
Cornelis J. M. Melief
Cornelis J. M. Melief ISA Pharmaceuticals (Netherlands)
Krista E. van Meijgaarden
Krista E. van Meijgaarden Leiden University Medical Center
Jan W. Drijfhout
Jan W. Drijfhout Leiden University Medical Center
Sjoerd H. van der Burg
Sjoerd H. van der Burg Leiden University Medical Center
Rienk Offringa
Rienk Offringa German Cancer Research Center
Michèl R. Klein
Michèl R. Klein Leiden University Medical Center
Ferry Ossendorp
Ferry Ossendorp Leiden University Medical Center
Abraham Aseffa
Abraham Aseffa Armauer Hansen Research Institute

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