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Immunology

D-Index
63
Citations
10371
World Ranking
3079
National Ranking
117

Overview

Annemieke Geluk is affiliated with Leiden University Medical Center in the Netherlands. Their research primarily focuses on various aspects of infectious diseases, with significant contributions across medical fields such as infectious diseases, epidemiology, surgery, immunology, and rheumatology.

Their research topics encompass a broad range of studies including:

  • Mycobacterium research and diagnosis
  • Leprosy research and treatment
  • Tuberculosis research and epidemiology
  • Infectious diseases and tuberculosis
  • Rheumatoid arthritis research and therapies
  • Systemic lupus erythematosus research
  • SARS-CoV-2 and COVID-19 research

Among recent publications by Annemieke Geluk are the following:

  • RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response, 2020, Scientific Reports
  • Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19, 2021, Nature Immunology
  • Diagnostic Accuracy of the Cepheid 3-gene Host Response Fingerstick Blood Test in a Prospective, Multi-site Study: Interim Results, 2021, Clinical Infectious Diseases
  • T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection, 2023, Nature Medicine
  • Mycobacterium leprae transmission characteristics during the declining stages of leprosy incidence: A systematic review, 2021, PLoS Neglected Tropical Diseases

Annemieke Geluk collaborates frequently with the following co-authors:

  • Anouk van Hooij
  • Paul L. A. M. Corstjens
  • Gerhard Walzl
  • Tom H. M. Ottenhoff
  • Louise Pierneef

The most frequent publication venues for Annemieke Geluk's work include:

  • Scientific Reports
  • PLoS Neglected Tropical Diseases
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Microbiology
  • Frontiers in Immunology

The body of work strongly aligns with clinical and translational research in infectious diseases, with a pronounced emphasis on tuberculosis and leprosy, as indicated by the concentration of publications and topics.

Best Publications

  • Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1

    Coenraad Kuijl;Nigel D. L. Savage;Marije Marsman;Adriaan W. Tuin

  • Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1.

    Nigel D. L. Savage;Tjitske de Boer;Kimberley V. Walburg;Simone A. Joosten

  • Antigenic Equivalence of Human T-Cell Responses to Mycobacterium tuberculosis-Specific RD1-Encoded Protein Antigens ESAT-6 and Culture Filtrate Protein 10 and to Mixtures of Synthetic Peptides

    Sandra M. Arend;Annemieke Geluk;Krista E. van Meijgaarden;Jaap T. van Dissel

  • Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis.

    Maytal Bivas-Benita;Krista E. van Meijgaarden;Kees L.M.C. Franken;Hans E. Junginger

  • Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4.

    Simone A. Joosten;Krista E. van Meijgaarden;Nigel D. L. Savage;Tjitske de Boer

  • Natural T-helper immunity against human papillomavirus type 16 (HPV16) E7-derived peptide epitopes in patients with HPV16-positive cervical lesions: identification of 3 human leukocyte antigen class II-restricted epitopes.

    Sjoerd H. van der Burg;Maaike E. Ressing;Kitty M.C. Kwappenberg;Annemieke de Jong

  • Identification of Major Epitopes of Mycobacterium tuberculosis AG85B That Are Recognized by HLA-A*0201-Restricted CD8+ T Cells in HLA-Transgenic Mice and Humans

    A. Geluk;K. E. van Meijgaarden;K. L. M. C. Franken;J. W. Drijfhout

  • Frequent Detection of Human Papillomavirus 16 E2-specific T-helper Immunity in Healthy Subjects

    Annemieke de Jong;Sjoerd H. van der Burg;Kitty M. C. Kwappenberg;Jeanette M. van der Hulst

  • Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB

    Novel N Chegou;Jayne S Sutherland;Stephanus Malherbe;Amelia C Crampin

  • Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8+ T-cells with cytotoxic as well as regulatory activity.

    Simone A. Joosten;Krista E. van Meijgaarden;Pascale C. van Weeren;Fatima Kazi

  • Identification and characterization of the ESAT-6 homologue of Mycobacterium leprae and T-cell cross-reactivity with Mycobacterium tuberculosis.

    Annemieke Geluk;Krista E. van Meijgaarden;Kees L. M. C. Franken;Yanri W. Subronto

  • RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

    Adam Penn-Nicholson;Stanley Kimbung Mbandi;Ethan Thompson;Simon C Mendelsohn

  • Metabolite changes in blood predict the onset of tuberculosis

    January rd Weiner;Jeroen Maertzdorf;Jayne S. Sutherland;Fergal J. Duffy

  • Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19

    Unknown

  • Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity

    Simone A Joosten;Krista E van Meijgaarden;Pascale C van Weeren;Fatima Kazi

  • T-Cell Recognition of the HspX Protein of Mycobacterium tuberculosis Correlates with Latent M. tuberculosis Infection but Not with M. bovis BCG Vaccination

    Annemieke Geluk;May Young Lin;Krista E. van Meijgaarden;Eliane M. S. Leyten

  • Molecular mimicry in diabetes mellitus: the homologous domain in coxsackie B virus protein 2C and islet autoantigen GAD65 is highly conserved in the coxsackie B-like enteroviruses and binds to the diabetes associated HLA-DR3 molecule

    G. R. Vreugdenhil;A. Geluk;T. H. M. Ottenhoff;W. J. G. Melchers

  • Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination.

    May Young Lin;Annemieke Geluk;Steven G. Smith;Amanda L. Stewart

  • Functional analysis of DR17(DR3)-restricted mycobacterial T cell epitopes reveals DR17-binding motif and enables the design of allele-specific competitor peptides.

    A Geluk;K E Van Meijgaarden;A A Janson;J W Drijfhout

  • Double- and monofunctional CD4+ and CD8+ T-cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long-term latently infected individuals

    Susanna Commandeur;May Y. Lin;May Y. Lin;Krista E. van Meijgaarden;Annemieke H. Friggen

  • HLA-DR3 molecules can bind peptides carrying two alternative specific submotifs.

    A. Geluk;K. E. Van Meijgaarden;S. Southwood;C. Oseroff

Frequent Co-Authors

Tom H. M. Ottenhoff
Tom H. M. Ottenhoff Leiden University Medical Center
Kees L. M. C. Franken
Kees L. M. C. Franken Leiden University Medical Center
Krista E. van Meijgaarden
Krista E. van Meijgaarden Leiden University Medical Center
Abraham Aseffa
Abraham Aseffa Armauer Hansen Research Institute
Jan W. Drijfhout
Jan W. Drijfhout Leiden University Medical Center
Stewart T. Cole
Stewart T. Cole Institut Pasteur
Patrick J. Brennan
Patrick J. Brennan Colorado State University
Simone A. Joosten
Simone A. Joosten Leiden University Medical Center
Hazel M. Dockrell
Hazel M. Dockrell London School of Hygiene & Tropical Medicine
Michèl R. Klein
Michèl R. Klein Leiden University Medical Center

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