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Biology and Biochemistry

D-Index
69
Citations
16471
World Ranking
7418
National Ranking
576

Overview

Barbara Mulloy is affiliated with Imperial College London in the United Kingdom. Their research spans multiple disciplines within biochemistry, genetics, molecular biology, and medicine, with a significant focus on molecular and cell biology as well as immunology and internal medicine.

The primary areas of study for Barbara Mulloy include proteoglycans and glycosaminoglycans research, glycosylation and glycoproteins research, venous thromboembolism diagnosis and management, heparin-induced thrombocytopenia and thrombosis, neutrophil, myeloperoxidase and oxidative mechanisms, carbohydrate chemistry and synthesis, and venomous animal envenomation studies.

Barbara Mulloy's recent papers cover a range of topics related to pharmacology, inflammatory responses, biochemical analysis techniques, and genomic editing related to heparin and sepsis. Notable recent publications include:

  • Pharmacology of Heparin and Related Drugs: An Update, 2023, Pharmacological Reviews
  • Heparin and non-anticoagulant heparin attenuate histone-induced inflammatory responses in whole blood, 2020, PLoS ONE
  • High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS, 2021, Communications Chemistry
  • Heparin, Heparan Sulphate and Sepsis: Potential New Options for Treatment, 2023, Pharmaceuticals
  • Multiplex genome editing of mammalian cells for producing recombinant heparin, 2022, Metabolic Engineering

Frequent publication venues for Barbara Mulloy include PLoS ONE, Methods in Molecular Biology, Pharmacological Reviews, Pharmaceuticals, and Communications Chemistry.

The scientist has collaborated regularly with several co-authors, including Elaine Gray, John Hogwood, Clive Page, Andrew L. Hook, and Catherine L.R. Merry.

Best Publications

  • Sulfated fucans, fresh perspectives : structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide

    Olivier Berteau;Barbara Mulloy

  • Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin.

    Luca Pellegrini;David F. Burke;Frank von Delft;Barbara Mulloy

  • N.m.r. and molecular-modelling studies of the solution conformation of heparin

    B Mulloy;M J Forster;C Jones;D B Davies

  • Structure and Anticoagulant Activity of Sulfated Fucans COMPARISON BETWEEN THE REGULAR, REPETITIVE, AND LINEAR FUCANS FROM ECHINODERMS WITH THE MORE HETEROGENEOUS AND BRANCHED POLYMERS FROM BROWN ALGAE

    Mariana S. Pereira;Barbara Mulloy;Paulo A. S. Mourão

  • Glycolipids as receptors for Bacillus thuringiensis crystal toxin.

    Joel S. Griffitts;Stuart M. Haslam;Tinglu Yang;Stephan F. Garczynski

  • Conformation and dynamics of heparin and heparan sulfate

    Barbara Mulloy;Mark J. Forster

  • Structure and Anticoagulant Activity of a Fucosylated Chondroitin Sulfate from Echinoderm SULFATED FUCOSE BRANCHES ON THE POLYSACCHARIDE ACCOUNT FOR ITS HIGH ANTICOAGULANT ACTION

    Paulo A.S. Mourão;Mariana S. Pereira;Mauro S.G. Pavão;Barbara Mulloy

  • Pharmacology of Heparin and Related Drugs

    Barbara Mulloy;John Hogwood;Elaine Gray;Rebecca Lever

  • A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae.

    Lionel Chevolot;Lionel Chevolot;Barbara Mulloy;Jacqueline Ratiskol;Alain Foucault;Alain Foucault

  • Characterization of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation.

    Vaclav Veverka;Alistair J. Henry;Patrick M. Slocombe;Andrew Ventom

  • Structure of a fucose-branched chondroitin sulfate from sea cucumber. Evidence for the presence of 3-O-sulfo-beta-D-glucuronosyl residues.

    R P Vieira;B Mulloy;P A Mourão

  • Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists.

    Christopher C. Rider;Barbara Mulloy

  • Sulfated fucans from echinoderms have a regular tetrasaccharide repeating unit defined by specific patterns of sulfation at the 0-2 and 0-4 positions.

    B. Mulloy;A.-C. Ribeiro;A.-P. Alves;R. P. Vieira

  • VEGF165-binding sites within heparan sulfate encompass two highly sulfated domains and can be liberated by K5 lyase

    Christopher J. Robinson;Barbara Mulloy;John T. Gallagher;Sally E. Stringer

  • Highly Sulfated Dermatan Sulfates from Ascidians STRUCTURE VERSUS ANTICOAGULANT ACTIVITY OF THESE GLYCOSAMINOGLYCANS

    Mauro S.G. Pavão;Karin R.M. Aiello;Claudio C. Werneck;Luiz Claudio F. Silva

  • The molecular-weight range of mucosal-heparin preparations.

    Edward A. Johnson;Barbara Mulloy

  • Sulfated Polysaccharides from the Egg Jelly Layer Are Species-specific Inducers of Acrosomal Reaction in Sperms of Sea Urchins

    Ana-Paula Alves;Barbara Mulloy;José A. Diniz;Paulo A.S. Mourão

  • His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form.

    Simon J. Clark;Victoria A. Higman;Barbara Mulloy;Stephen J. Perkins

  • Order out of complexity – protein structures that interact with heparin

    Barbara Mulloy;Robert J Linhardt

  • Isolation and partial characterization of fucan sulfates from the body wall of sea cucumber Stichopus japonicus and their ability to inhibit osteoclastogenesis.

    Yutaka Kariya;Barbara Mulloy;Kyoko Imai;Akihiro Tominaga

Frequent Co-Authors

Paulo A.S. Mourão
Paulo A.S. Mourão Federal University of Rio de Janeiro
Stephen J. Perkins
Stephen J. Perkins University College London
Anthony J. Day
Anthony J. Day University of Manchester
Robin Wait
Robin Wait Imperial College London
Tom L. Blundell
Tom L. Blundell University of Cambridge
Ten Feizi
Ten Feizi Imperial College London
Robert B. Sim
Robert B. Sim University of Oxford
John T. Gallagher
John T. Gallagher University of Manchester
Susan M. Lea
Susan M. Lea University of Oxford
Douglas M. Tollefsen
Douglas M. Tollefsen Washington University in St. Louis

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