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Chemistry

D-Index
62
Citations
12667
World Ranking
8901
National Ranking
495

Biology and Biochemistry

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62
Citations
12782
World Ranking
10868
National Ranking
835

Overview

Wengang Chai is affiliated with Imperial College London in the United Kingdom. Their research spans multiple domains primarily within Medicine and Biochemistry, Genetics and Molecular Biology, with a particular concentration on Molecular Biology, Infectious Diseases, Epidemiology, Immunology, and Nutrition and Dietetics.

The scientist's work is notably focused on glycosylation and glycoproteins research, with 30 publications covering this topic. Other key research areas include infant nutrition and health, monoclonal and polyclonal antibodies research, galectins and cancer biology, carbohydrate chemistry and synthesis, SARS-CoV-2 and COVID-19 research, and breastfeeding practices and influences.

Wengang Chai has contributed to several frequent publication venues, demonstrating recurring collaboration with these journals and platforms:

  • PLoS Pathogens
  • Carbohydrate Polymers
  • SSRN Electronic Journal
  • Glycobiology
  • Nature Communications

Frequent co-authors include Ten Feizi, Yan Liu, Jingyu Yan, Virginia Tajadura-Ortega, and Angelina S. Palma, reflecting a collaborative approach in their research projects across various topics and institutions.

Notable recent publications by Wengang Chai include:

  • Mannan detecting C-type lectin receptor probes recognise immune epitopes with diverse chemical, spatial and phylogenetic heterogeneity in fungal cell walls, 2020, PLoS Pathogens
  • Siglec-15 recognition of sialoglycans on tumor cell lines can occur independently of sialyl Tn antigen expression, 2020, Glycobiology
  • SARS-CoV-2 spike protein causes blood coagulation and thrombosis by competitive binding to heparan sulfate, 2021, International Journal of Biological Macromolecules
  • Chikungunya Virus Strains from Each Genetic Clade Bind Sulfated Glycosaminoglycans as Attachment Factors, 2020, Journal of Virology
  • The effect of N-glycosylation of SARS-CoV-2 spike protein on the virus interaction with the host cell ACE2 receptor, 2021, iScience

Best Publications

  • Oligosaccharide microarrays for high-throughput detection and specificity assignments of carbohydrate-protein interactions

    Shigeyuki Fukui;Ten Feizi;Christine Galustian;Alexander M. Lawson

  • GM1 structure determines SV40-induced membrane invagination and infection

    Helge Ewers;Winfried Römer;Winfried Römer;Alicia E. Smith;Kirsten Bacia;Kirsten Bacia

  • Ligands for the β-glucan receptor, dectin-1, assigned using "designer" microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysaccharides

    Angelina S. Palma;Ten Feizi;Yibing Zhang;Mark S. Stoll

  • Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria.

    James G. Beeson;Stephen J. Rogerson;Stephen J. Rogerson;Brian M. Cooke;John C. Reeder

  • Carbohydrate microarrays - a new set of technologies at the frontiers of glycomics.

    Ten Feizi;Fabio Fazio;Wengang Chai;Chi Huey Wong

  • Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray

    Robert A Childs;Angelina S Palma;Steve Wharton;Tatyana Matrosovich

  • Comparison of structures and anticoagulant activities of fucosylated chondroitin sulfates from different sea cucumbers

    Shiguo Chen;Changhu Xue;Li’ang Yin;Qingjuan Tang

  • Retraction: Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity

    Karel Bezouška;Chun-Ting Yuen;Jacqui O’Brien;Robert A. Childs

  • Novel sulfated ligands for the cell adhesion molecule E-selectin revealed by the neoglycolipid technology among O-linked oligosaccharides on an ovarian cystadenoma glycoprotein.

    Chun Ting Yuen;Alexander M. Lawson;Wengang Chai;Margot Larkin

  • Oligosaccharide microarrays to decipher the glyco code

    Ten Feizi;Wengang Chai

  • Negative-ion electrospray mass spectrometry of neutral underivatized oligosaccharides.

    Wengang Chai;Viadimir Piskarev;Alexander M. Lawson

  • Altered Receptor Specificity and Cell Tropism of D222G Hemagglutinin Mutants Isolated from Fatal Cases of Pandemic A(H1N1) 2009 Influenza Virus

    Yan Liu;Robert A. Childs;Tatyana Matrosovich;Stephen Wharton

  • Interactions with heparin-like molecules during erythrocyte invasion by Plasmodium falciparum merozoites.

    Michelle J. Boyle;Michelle J. Boyle;Jack S. Richards;Jack S. Richards;Paul R. Gilson;Wengang Chai

  • The Cysteine-Rich Domain of the Macrophage Mannose Receptor Is a Multispecific Lectin That Recognizes Chondroitin Sulfates a and B and Sulfated Oligosaccharides of Blood Group Lewisa and Lewisx Types in Addition to the Sulfated N-Glycans of Lutropin

    Christine Leteux;Wengang Chai;R. Wendy Loveless;Chun-Ting Yuen

  • High and low affinity carbohydrate ligands revealed for murine SIGN-R1 by carbohydrate array and cell binding approaches, and differing specificities for SIGN-R3 and langerin.

    Christine Galustian;Chae Gyu Park;Wengang Chai;Makato Kiso

  • High prevalence of 2‐mono‐ and 2,6‐di‐substituted Manol‐terminating sequences among O‐glycans released from brain glycopeptides by reductive alkaline hydrolysis

    Wengang Chai;Chun-Ting Yuen;Heide Kogelberg;Robert A. Carruthers

  • Sequence determination and anticoagulant and antithrombotic activities of a novel sulfated fucan isolated from the sea cucumber Isostichopus badionotus

    Shiguo Chen;Yaqin Hu;Xinqian Ye;Guoyun Li

  • N-Glycolyl GM1 Ganglioside as a Receptor for Simian Virus 40

    Maria A. Campanero-Rhodes;Alicia Smith;Wengang Chai;Sandro Sonnino

  • Branching pattern and sequence analysis of underivatized oligosaccharides by combined MS/MS of singly and doubly charged molecular ions in negative-ion electrospray mass spectrometry.

    Wengang Chai;Alexander M. Lawson;Vladimir Piskarev

  • Brain Contains HNK-1 Immunoreactive O-Glycans of the Sulfoglucuronyl Lactosamine Series that Terminate in 2-Linked or 2,6-Linked Hexose (Mannose)

    Chun-Ting Yuen;Wengang Chai;R. Wendy Loveless;Alexander M. Lawson

  • Ligands for the β-glucan receptor, Dectin-1, assigned using “designer” microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysaccharides. VOLUME 281 (2006) PAGES 5771-5779

    Angelina S. Palma;Ten Feizi;Yibing Zhang;Mark S. Stoll

Frequent Co-Authors

Ten Feizi
Ten Feizi Imperial College London
Alexander M. Lawson
Alexander M. Lawson Imperial College London
Guangli Yu
Guangli Yu Ocean University of China
James G. Beeson
James G. Beeson Burnet Institute
Gordon D. Brown
Gordon D. Brown University of Exeter
Shiguo Chen
Shiguo Chen Zhejiang University
Xinmiao Liang
Xinmiao Liang Chinese Academy of Sciences
Mikhail Matrosovich
Mikhail Matrosovich Philipp University of Marburg
Neil A. R. Gow
Neil A. R. Gow University of Exeter
Michael Bachmann
Michael Bachmann Helmholtz-Zentrum Dresden-Rossendorf

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