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2025
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Immunology
USA
2026

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Best Scientists

D-Index
183
Citations
119290
World Ranking
554
National Ranking
354

Immunology

D-Index
187
Citations
127706
World Ranking
25
National Ranking
18

Medicine

D-Index
187
Citations
127755
World Ranking
284
National Ranking
185

Research.com Recognitions

  • 2026 - Research.com Immunology in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Immunology in United States Leader Award
  • 2019 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1995 - AAI-BD Biosciences Investigator Award, American Association of Immunologists

Overview

Alessandro Sette is affiliated with the La Jolla Institute For Allergy & Immunology in the United States and has an extensive research portfolio in medicine, immunology, and microbiology. Their work focuses primarily on infectious diseases, immunology, and molecular biology, with a significant emphasis on SARS-CoV-2 and COVID-19 research.

The scientist has authored numerous publications related to immune responses and vaccine development, specifically examining the adaptive immune system's role in SARS-CoV-2 infection and COVID-19. Key research topics include:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Vaccines and Immunoinformatics Approaches
  • Immunotherapy and Immune Responses
  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • Long-Term Effects of COVID-19

Alessandro Sette's research contributions are frequently published in various venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Immunology
  • Frontiers in Immunology
  • Zenodo (CERN European Organization for Nuclear Research)
  • Cell Host & Microbe

Several influential papers from their recent work include:

  • Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals (2020, Cell)
  • Immunological Memory to SARS-CoV-2 Assessed for up to 8 Months After Infection (2021, Science)
  • Adaptive Immunity to SARS-CoV-2 and COVID-19 (2021, Cell)
  • Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity (2020, Cell)
  • Selective and Cross-reactive SARS-CoV-2 T Cell Epitopes in Unexposed Humans (2020, Science)

Collaborations form a core part of their work, with frequent co-authors including:

  • Alba Grifoni
  • Daniela Weiskopf
  • Bjoern Peters
  • Cecilia S. Lindestam Arlehamn
  • John Sidney

The research fields covered by Alessandro Sette span a broad spectrum of biomedical science with 825 publications in medicine and 324 in immunology and microbiology. Subfields of particular focus are infectious diseases (458 publications), immunology (279 publications), molecular biology (163 publications), neurology (100 publications), and epidemiology (99 publications).

Awards received in recognition of contributions to the field include:

  • Fellow of the American Association for the Advancement of Science (AAAS), 2019
  • AAI-BD Biosciences Investigator Award, American Association of Immunologists, 1995

Best Publications

  • Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals.

    Alba Grifoni;Daniela Weiskopf;Sydney I. Ramirez;Sydney I. Ramirez;Jose Mateus

  • Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection.

    Jennifer M. Dan;Jennifer M. Dan;Jose Mateus;Yu Kato;Kathryn M. Hastie

  • The Immune Epitope Database (IEDB): 2018 update.

    Randi Vita;Swapnil Mahajan;James A Overton;Sandeep Kumar Dhanda

  • Adaptive immunity to SARS-CoV-2 and COVID-19.

    Alessandro Sette;Alessandro Sette;Shane Crotty;Shane Crotty

  • Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity.

    Carolyn Rydyznski Moderbacher;Sydney I. Ramirez;Sydney I. Ramirez;Jennifer M. Dan;Jennifer M. Dan;Alba Grifoni

  • ElliPro: a new structure-based tool for the prediction of antibody epitopes

    Julia V. Ponomarenko;Julia V. Ponomarenko;Huynh-Hoa Bui;Wei Li;Nicholas Fusseder

  • The immune epitope database (IEDB) 3.0

    Randi Vita;James A. Overton;Jason A. Greenbaum;Julia V. Ponomarenko

  • Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans.

    Jose Mateus;Alba Grifoni;Alison Tarke;John Sidney

  • The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.

    A. Sette;A. Vitiello;B. Reherman;P. Fowler

  • Identifying specificity groups in the T cell receptor repertoire

    Jacob Glanville;Huang Huang;Allison Nau;Olivia Hatton

  • A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2

    Alba Grifoni;John Sidney;Yun Zhang;Richard H. Scheuermann

  • A Systematic Assessment of MHC Class II Peptide Binding Predictions and Evaluation of a Consensus Approach

    Peng Wang;John Sidney;Courtney Dow;Courtney Dow;Bianca Mothé

  • Predicting population coverage of T-cell epitope-based diagnostics and vaccines

    Huynh-Hoa Bui;John Sidney;Kenny Dinh;Scott Southwood

  • Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule.

    Jonathan A. Hill;Scott Southwood;Alessandro Sette;Anthony M. Jevnikar

  • Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia.

    Todd M. Allen;David H. O'Connor;Peicheng Jing;John L. Dzuris

  • Properties of MHC Class I Presented Peptides That Enhance Immunogenicity

    Jorg J. A. Calis;Matt Maybeno;Jason A. Greenbaum;Daniela Weiskopf

  • The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients.

    Lakshmanane Premkumar;Bruno Segovia-Chumbez;Ramesh Jadi;David R. Martinez

  • Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules

    Jörg Ruppert;John Sidney;Esteban Celis;Ralph T. Kubo

  • Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome.

    Daniela Weiskopf;Katharina S. Schmitz;Matthijs P. Raadsen;Alba Grifoni

  • Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

    Michela Locci;Michela Locci;Colin Havenar-Daughton;Colin Havenar-Daughton;Elise Landais;Jennifer Wu

  • The relation between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind immunogenic peptides.

    Soren Buus;Alessandro Sette;Sonia M. Colon;Craig Miles

  • Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad

    Donald F. Hunt;Hanspeter Michel;Tracey A. Dickinson;Jeffrey Shabanowitz

Frequent Co-Authors

Bjoern Peters
Bjoern Peters La Jolla Institute For Allergy & Immunology
John Sidney
John Sidney La Jolla Institute For Allergy & Immunology
Howard M. Grey
Howard M. Grey La Jolla Institute For Allergy & Immunology
Daniela Weiskopf
Daniela Weiskopf La Jolla Institute For Allergy & Immunology
Cecilia S. Lindestam Arlehamn
Cecilia S. Lindestam Arlehamn La Jolla Institute For Allergy & Immunology
Scott Southwood
Scott Southwood Johnson & Johnson
Jason A. Greenbaum
Jason A. Greenbaum La Jolla Institute For Allergy & Immunology
Carla Oseroff
Carla Oseroff La Jolla Institute For Allergy & Immunology
Alba Grifoni
Alba Grifoni La Jolla Institute For Allergy & Immunology
Shane Crotty
Shane Crotty La Jolla Institute For Allergy & Immunology

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