World's Best Scientists 2026 revealed!

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Immunology

D-Index
114
Citations
43590
World Ranking
418
National Ranking
16

Medicine

D-Index
114
Citations
43619
World Ranking
4779
National Ranking
183

Overview

Tom H. M. Ottenhoff is affiliated with Leiden University Medical Center in the Netherlands. Their research primarily focuses on Medicine and Immunology and Microbiology, reflecting an extensive body of work in these areas. The scientist has contributed significantly to studies within the subfields of Infectious Diseases, Immunology, Epidemiology, Molecular Biology, and Surgery.

The main research topics explored include Tuberculosis Research and Epidemiology, Mycobacterium research and diagnosis, Immune Cell Function and Interaction, T-cell and B-cell Immunology, Viral Infections and Outbreaks Research, Immunodeficiency and Autoimmune Disorders, and Immune responses and vaccinations.

Frequent co-authors collaborating with Tom H. M. Ottenhoff are:

  • Simone A. Joosten
  • Mariëlle C. Haks
  • Kees L. M. C. Franken
  • Krista E. van Meijgaarden
  • Suzanne van Veen

The scientist has published extensively in several venues, with the most frequent being:

  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • iScience
  • Frontiers in Cellular and Infection Microbiology

Notable recent papers authored or co-authored by Tom H. M. Ottenhoff include:

  • RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response, 2020, Scientific Reports
  • Host-directed therapy to combat mycobacterial infections, 2021, Immunological Reviews
  • Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19, 2021, Nature Immunology
  • B-Cells and Antibodies as Contributors to Effector Immune Responses in Tuberculosis, 2021, Frontiers in Immunology
  • T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection, 2023, Nature Medicine

Best Publications

  • Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria

    Frank A. W. Verreck;Tjitske de Boer;Dennis M. L. Langenberg;Marieke A. Hoeve

  • Innate immunity to Mycobacterium tuberculosis.

    Reinout van Crevel;Tom H M Ottenhoff;Jos W M van der Meer

  • Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients

    Rolien de Jong;Frédéric Altare;Inez-Anne Haagen;Diënne G. Elferink

  • A blood RNA signature for tuberculosis disease risk: a prospective cohort study.

    Daniel E Zak;Adam Penn-Nicholson;Thomas J Scriba;Ethan Thompson

  • Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans.

    Mary E. Morgan;Jolanda H.M. van Bilsen;Aleida M. Bakker;Bianca Heemskerk

  • Vaccines against tuberculosis: where are we and where do we need to go?

    Tom H. M. Ottenhoff;Stefan H. E. Kaufmann

  • The Effect of Type 2 Diabetes Mellitus on the Presentation and Treatment Response of Pulmonary Tuberculosis

    Bachti Alisjahbana;Edhyana Sahiratmadja;Erni J. Nelwan;Anugrah Maya Purwa

  • Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-gamma- and CD40L-mediated costimulation.

    Frank A. W. Verreck;Tjitske de Boer;Dennis M. L. Langenberg;Linda van der Zanden

  • MANNOSE RECEPTOR-MEDIATED UPTAKE OF ANTIGENS STRONGLY ENHANCES HLA CLASS II-RESTRICTED ANTIGEN PRESENTATION BY CULTURED DENDRITIC CELLS

    M. C. A. A. Tan;A. M. Mommaas;J. W. Drijfhout;R. Jordens

  • NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis.

    Gerben Ferwerda;Stephen E. Girardin;Bart Jan Kullberg;Lionel Le Bourhis

  • Novel human immunodeficiencies reveal the essential role of type-1 cytokines in immunity to intracellular bacteria

    Tom H.M Ottenhoff;Dinakantha Kumararatne;Jean-Laurent Casanova

  • Detection of Tuberculosis in HIV-Infected and -Uninfected African Adults Using Whole Blood RNA Expression Signatures: A Case-Control Study

    Myrsini Kaforou;Victoria J. Wright;Tolu Oni;Tolu Oni;Neil French;Neil French

  • Diagnosis of childhood tuberculosis and host RNA expression in Africa.

    Suzanne T. Anderson;Myrsini Kaforou;Andrew J. Brent;Victoria J. Wright

  • Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection

    Nadia Caccamo;Giuliana Guggino;Simone A. Joosten;Giuseppe Gelsomino

  • Selection of a human T helper type 1-like T cell subset by mycobacteria.

    J. B. A. G. Haanen;R. De Waal Malefijt;P. C. M. Res;E. M. Kraakman

  • Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1

    Coenraad Kuijl;Nigel D. L. Savage;Marije Marsman;Adriaan W. Tuin

  • Is there a future for TNF promoter polymorphisms

    J-P Bayley;T H M Ottenhoff;C L Verweij

  • Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis.

    Eliane M.S. Leyten;May Young Lin;Kees L.M.C. Franken;Annemieke H. Friggen

  • Purification of his-tagged proteins by immobilized chelate affinity chromatography: the benefits from the use of organic solvent.

    Kees L.M.C. Franken;Hoebert S. Hiemstra;Krista E. van Meijgaarden;Yanri Subronto

  • Genetics, cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae.

    Tom H.M. Ottenhoff;Frank A.W. Verreck;Elgin G.R. Lichtenauer-Kaligis;Marieke A. Hoeve

Frequent Co-Authors

Kees L. M. C. Franken
Kees L. M. C. Franken Leiden University Medical Center
Krista E. van Meijgaarden
Krista E. van Meijgaarden Leiden University Medical Center
Annemieke Geluk
Annemieke Geluk Leiden University Medical Center
Simone A. Joosten
Simone A. Joosten Leiden University Medical Center
Hazel M. Dockrell
Hazel M. Dockrell London School of Hygiene & Tropical Medicine
Jaap T. van Dissel
Jaap T. van Dissel Leiden University Medical Center
Gerhard Walzl
Gerhard Walzl Stellenbosch University
Stefan H. E. Kaufmann
Stefan H. E. Kaufmann Max Planck Institute for Infection Biology
Reinout van Crevel
Reinout van Crevel Radboud University
Michèl R. Klein
Michèl R. Klein Leiden University Medical Center

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