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Immunology

D-Index
75
Citations
22004
World Ranking
1977
National Ranking
7

Overview

Thomas J. Scriba is affiliated with the University of Cape Town in South Africa and has an extensive research profile primarily focused on tuberculosis and immunology. Their work spans multiple interconnected fields of study, including medicine, immunology and microbiology, as well as subfields such as immunology, infectious diseases, epidemiology, surgery, and molecular biology.

Their research topics consistently revolve around tuberculosis research and epidemiology, mycobacterium research and diagnosis, immune cell function and interaction, diagnosis and treatment of tuberculosis, T-cell and B-cell immunology, immunodeficiency and autoimmune disorders, and immune responses and vaccinations.

Among their recent papers are:

  • Analyzing the Mycobacterium tuberculosis immune response by T-cell receptor clustering with GLIPH2 and genome-wide antigen screening (2020, Nature Biotechnology)
  • RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response (2020, Scientific Reports)
  • Biomarker-guided tuberculosis preventive therapy (CORTIS): a randomised controlled trial (2021, The Lancet Infectious Diseases)
  • S100A8/A9 regulates CD11b expression and neutrophil recruitment during chronic tuberculosis (2020, Journal of Clinical Investigation)
  • Classification of early tuberculosis states to guide research for improved care and prevention: an international Delphi consensus exercise (2024, The Lancet Respiratory Medicine)

Thomas J. Scriba frequently collaborates with a number of coauthors, including Mark Hatherill, Simon C. Mendelsohn, Humphrey Mulenga, Gerhard Walzl, and Elisa Nemes. These collaborations have contributed significantly to their body of work in tuberculosis and immunology.

The scientist's work is often published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Immunology, The Journal of Immunology, SSRN Electronic Journal, and The Lancet Respiratory Medicine. This range of publication sources reflects the interdisciplinary nature and focus of their research.

Thomas J. Scriba's research contributions center on understanding immune mechanisms related to tuberculosis, advancing diagnostic signatures for disease risk, and improving preventive and treatment methods. Their work integrates genomic, immunologic, and clinical approaches to address the challenges posed by tuberculosis and related infectious diseases.

Best Publications

  • Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial

    Michele D Tameris;Mark Hatherill;Bernard S Landry;Thomas J Scriba

  • Identifying specificity groups in the T cell receptor repertoire

    Jacob Glanville;Huang Huang;Allison Nau;Olivia Hatton

  • A blood RNA signature for tuberculosis disease risk: a prospective cohort study.

    Daniel E Zak;Adam Penn-Nicholson;Thomas J Scriba;Ethan Thompson

  • Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination

    Elisa Nemes;Hennie Geldenhuys;Virginie Rozot;Kathryn T Rutkowski

  • Immunological biomarkers of tuberculosis.

    Gerhard Walzl;Katharina Ronacher;Willem Hanekom;Thomas J. Scriba

  • Final Analysis of a Trial of M72/AS01E Vaccine to Prevent Tuberculosis

    Dereck R. Tait;Mark Hatherill;Olivier Van Der Meeren;Ann M. Ginsberg

  • Distinct, Specific IL-17- and IL-22-Producing CD4+ T Cell Subsets Contribute to the Human Anti-Mycobacterial Immune Response

    Thomas J. Scriba;Barbara Kalsdorf;Deborah-Ann Abrahams;Fatima Isaacs

  • Specific T Cell Frequency and Cytokine Expression Profile Do Not Correlate with Protection against Tuberculosis after Bacillus Calmette-Guérin Vaccination of Newborns

    Benjamin M. N. Kagina;Brian Abel;Thomas J. Scriba;Elizabeth J. Hughes

  • Analyzing the Mycobacterium tuberculosis immune response by T-cell receptor clustering with GLIPH2 and genome-wide antigen screening.

    Huang Huang;Chunlin Wang;Florian Rubelt;Thomas J. Scriba

  • Phase 2b Controlled Trial of M72/AS01E Vaccine to Prevent Tuberculosis

    Olivier Van Der Meeren;Mark Hatherill;Videlis Nduba;Robert J Wilkinson

  • T cells and adaptive immunity to Mycobacterium tuberculosis in humans

    Luke D. Jasenosky;Thomas J. Scriba;Willem A. Hanekom;Willem A. Hanekom;Anne E. Goldfeld

  • T-cell activation is an immune correlate of risk in BCG vaccinated infants

    Helen A. Fletcher;Helen A. Fletcher;Margaret A. Snowden;Bernard Landry;Wasima Rida

  • COMPASS identifies T-cell subsets correlated with clinical outcomes

    Lin Lin;Greg Finak;Kevin Ushey;Chetan Seshadri

  • Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis

    Sara Suliman;Ethan G. Thompson;Jayne Sutherland;January Weiner rd

  • Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8 + T cells

    Lucy J. Walker;Yu-Hoi Kang;Matthew O. Smith;Hannah Tharmalingham

  • Bacillus Calmette-Guérin Vaccination of Human Newborns Induces T Cells with Complex Cytokine and Phenotypic Profiles

    Andreia P. Soares;Thomas J. Scriba;Sarah Joseph;Ryhor Harbacheuski

  • Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells

    Thomas J. Scriba;Michele Tameris;Nazma Mansoor;Erica Smit

  • A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes

    Roshni Roy Chowdhury;Francesco Vallania;Qianting Yang;Cesar Joel Lopez Angel

  • Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease.

    Thomas J Scriba;Adam Penn-Nicholson;Smitha Shankar;Tom Hraha

  • Safety and Immunogenicity of a New Tuberculosis Vaccine, MVA85A, in Healthy Adults in South Africa

    Tony Hawkridge;Thomas J. Scriba;Sebastian Gelderbloem;Erica Smit

Frequent Co-Authors

Willem A. Hanekom
Willem A. Hanekom University College London
Gerhard Walzl
Gerhard Walzl Stellenbosch University
Helen McShane
Helen McShane University of Oxford
Helen A. Fletcher
Helen A. Fletcher London School of Hygiene & Tropical Medicine
Cheryl L. Day
Cheryl L. Day Emory University
Robert J. Wilkinson
Robert J. Wilkinson The Francis Crick Institute
Cecilia S. Lindestam Arlehamn
Cecilia S. Lindestam Arlehamn La Jolla Institute For Allergy & Immunology
Alessandro Sette
Alessandro Sette La Jolla Institute For Allergy & Immunology
Stefan H. E. Kaufmann
Stefan H. E. Kaufmann Max Planck Institute for Infection Biology
W. Henry Boom
W. Henry Boom Case Western Reserve University

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