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Microbiology

D-Index
73
Citations
17089
World Ranking
1688
National Ranking
725

Overview

W. Henry Boom is affiliated with Case Western Reserve University in the United States. Their research focuses broadly on medicine, with significant contributions in immunology and microbiology. Within these fields, they concentrate particularly on infectious diseases, immunology, and epidemiology, with additional work in molecular biology and surgery.

The scientist has contributed extensively to topics related to tuberculosis research and epidemiology as well as Mycobacterium research and diagnosis. They have also engaged in studies of immunodeficiency and autoimmune disorders, immune cell function and interaction, immune responses and vaccinations, immune response and inflammation, and infectious diseases with an emphasis on tuberculosis.

W. Henry Boom has published research in several venues, frequently appearing in bioRxiv (Cold Spring Harbor Laboratory), The Journal of Immunology, PLoS ONE, Journal of Clinical Investigation, and Antimicrobial Agents and Chemotherapy.

Some of their recent papers include the following:

  • The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis, 2020, The Lancet
  • Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis, 2022, The Lancet Global Health
  • RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response, 2020, Scientific Reports
  • The knowns and unknowns of latent Mycobacterium tuberculosis infection, 2021, Journal of Clinical Investigation
  • T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection, 2023, Nature Medicine

Frequent coauthors collaborating with W. Henry Boom include:

  • Catherine M. Stein
  • Harriet Mayanja-Kizza
  • Thomas R. Hawn
  • Penelope Benchek
  • Jason D. Simmons

Best Publications

  • A blood RNA signature for tuberculosis disease risk: a prospective cohort study.

    Daniel E Zak;Adam Penn-Nicholson;Thomas J Scriba;Ethan Thompson

  • Toll-Like Receptor 2-Dependent Inhibition of Macrophage Class II MHC Expression and Antigen Processing by 19-kDa Lipoprotein of Mycobacterium tuberculosis

    Erika H. Noss;Rish K. Pai;Timothy J. Sellati;Justin D. Radolf

  • Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors

    Clifford V. Harding;W. Henry Boom

  • T Cell Response to Mycobacterium tuberculosis

    I M Orme;P Andersen;W H Boom

  • Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.

    David Stucki;David Stucki;Daniela Brites;Daniela Brites;Leïla Jeljeli;Mireia Coscolla;Mireia Coscolla

  • Mycobacterium tuberculosis LprG (Rv1411c): a novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing.

    Adam J. Gehring;Karen M. Dobos;John T. Belisle;Clifford V. Harding

  • Inhibition of IFN-γ-Induced Class II Transactivator Expression by a 19-kDa Lipoprotein from Mycobacterium tuberculosis: A Potential Mechanism for Immune Evasion

    Rish K. Pai;Marilyn Convery;Thomas A. Hamilton;W. Henry Boom

  • Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection

    Jason D. Simmons;Catherine Marie Stein;Chetan Seshadri;Monica Campo

  • A role for CD4+CD25+ T cells in regulation of the immune response during human tuberculosis

    R. Ribeiro-Rodrigues;T. Resende Co;R. Rojas;Z. Toossi;Z. Toossi

  • Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis

    Sara Suliman;Ethan G. Thompson;Jayne Sutherland;January Weiner rd

  • Mycobacterium tuberculosis LprA Is a Lipoprotein Agonist of TLR2 That Regulates Innate Immunity and APC Function

    Nicole D. Pecora;Adam J. Gehring;David H. Canaday;W. Henry Boom

  • CD4(+) and CD8(+) T cells kill intracellular Mycobacterium tuberculosis by a perforin and Fas/Fas ligand-independent mechanism.

    David H. Canaday;Robert J. Wilkinson;Qing Li;Clifford V. Harding

  • Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes.

    W H Boom;D Liano;A K Abbas

  • Mycobacterium tuberculosis inhibits MHC class II antigen processing in murine bone marrow macrophages.

    Erika H. Noss;Clifford V. Harding;W.Henry Boom

  • Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-γ-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signaling

    Meghan E. Pennini;Rish K. Pai;David C. Schultz;W. Henry Boom

  • Cavitary disease and quantitative sputum bacillary load in cases of pulmonary tuberculosis.

    Moises Palaci;Reynaldo Dietze;David Jamil Hadad;Fabiola Karla Corrêa Ribeiro

  • Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease.

    Thomas J Scriba;Adam Penn-Nicholson;Smitha Shankar;Tom Hraha

  • Population Pharmacokinetics of Levofloxacin, Gatifloxacin, and Moxifloxacin in Adults with Pulmonary Tuberculosis

    Charles A. Peloquin;David Jamil Hadad;Lucilia Pereira Dutra Molino;Moises Palaci

  • Association of HIV and ART with cardiometabolic traits in sub-Saharan Africa: a systematic review and meta-analysis

    David G Dillon;David G Dillon;Deepti Gurdasani;Deepti Gurdasani;Johanna Riha;Johanna Riha;Kenneth Ekoru;Kenneth Ekoru

  • Human immune response to Mycobacterium tuberculosis antigens.

    D V Havlir;R S Wallis;W H Boom;T M Daniel

  • Prolonged toll-like receptor signaling by Mycobacterium tuberculosis and its 19-kilodalton lipoprotein inhibits gamma interferon-induced regulation of selected genes in macrophages.

    Rish K. Pai;Meghan E. Pennini;Aaron A. R. Tobian;David H. Canaday

  • The Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits gamma interferon-regulated HLA-DR and FcγR1 on human macrophages through toll-like receptor 2

    Adam J. Gehring;Roxana E. Rojas;David H. Canaday;David L. Lakey

Frequent Co-Authors

Clifford V. Harding
Clifford V. Harding Case Western Reserve University
Moses Joloba
Moses Joloba Makerere University
John L. Johnson
John L. Johnson Case Western Reserve University
Willem A. Hanekom
Willem A. Hanekom University College London
Thomas J. Scriba
Thomas J. Scriba University of Cape Town
Scott M. Williams
Scott M. Williams Case Western Reserve University
Gerhard Walzl
Gerhard Walzl Stellenbosch University
Sebastien Gagneux
Sebastien Gagneux University of Basel
Giorgio Sirugo
Giorgio Sirugo University of Pennsylvania
David M. Lewinsohn
David M. Lewinsohn Oregon Health & Science University

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