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Medicine
France
2023

D-Index & Metrics

Medicine

D-Index
140
Citations
68231
World Ranking
1706
National Ranking
45

Research.com Recognitions

  • 2023 - Research.com Medicine in France Leader Award

Overview

Laurent Abel is affiliated with Université Paris Cité in France. Their research spans several interconnected fields, primarily focusing on medicine, immunology and microbiology, and biochemistry, genetics and molecular biology.

The main subfields of their work include immunology, infectious diseases, genetics, epidemiology, and molecular biology. These areas reflect a broad and multidisciplinary approach to biomedical research.

The scientist's research topics cover a range of subjects related to immune function and infectious disease, including immunodeficiency and autoimmune disorders, COVID-19 clinical research studies, SARS-CoV-2 and COVID-19 research, immune cell function and interaction, interferon and immune responses, Mycobacterium research and diagnosis, and T-cell and B-cell immunology.

Laurent Abel has coauthored extensively with several collaborators. Frequent co-authors include:

  • Jean-Laurent Casanova
  • Aurélie Cobat
  • Paul Bastard
  • Jacinta Bustamante
  • Anne Puel

Their work appears frequently in several scientific journals, notably:

  • The Journal of Experimental Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Immunology
  • Cell
  • Journal of Clinical Investigation

Some recent notable publications include:

  • "Autoantibodies against type I IFNs in patients with life-threatening COVID-19" (2020, Science)
  • "X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19" (2021, Science Immunology)
  • "Human genetic and immunological determinants of critical COVID-19 pneumonia" (2022, Nature)
  • "Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1" (2021, The Journal of Experimental Medicine)
  • "A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection" (2020, Cell)

Best Publications

  • Autoantibodies against type I IFNs in patients with life-threatening COVID-19.

    Paul Bastard;Paul Bastard;Paul Bastard;Lindsey B. Rosen;Qian Zhang;Eleftherios Michailidis

  • Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

    Qian Zhang;Paul Bastard;Paul Bastard;Zhiyong Liu;Jérémie Le Pen

  • Genetic mechanisms of critical illness in Covid-19.

    E. Pairo-Castineira;E. Pairo-Castineira;S. Clohisey;L. Klaric;A. D. Bretherick

  • TLR3 deficiency in patients with herpes simplex encephalitis.

    Shen Ying Zhang;Shen Ying Zhang;Emmanuelle Jouanguy;Emmanuelle Jouanguy;Sophie Ugolini;Asma Smahi

  • Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

    Horst Von Bernuth;Capucine Picard;Capucine Picard;Zhongbo Jin;Rungnapa Pankla;Rungnapa Pankla

  • GENETIC DISSECTION OF IMMUNITY TO MYCOBACTERIA: THE HUMAN MODEL

    Jean-Laurent Casanova;Laurent Abel

  • Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity

    Anne Puel;Sophie Cypowyj;Jacinta Bustamante;Jill Wright

  • Mutations of the RET proto-oncogene in Hirschsprung's disease

    Patrick Edery;Stanislas Lyonnet;Lois M. Mulligan;Anna Pelet

  • Herpes simplex virus encephalitis in human UNC-93B deficiency.

    Armanda Casrouge;Shen Ying Zhang;Shen Ying Zhang;Céline Eidenschenk;Emmanuelle Jouanguy;Emmanuelle Jouanguy

  • Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

    Luyan Liu;Satoshi Okada;Xiao Fei Kong;Alexandra Y. Kreins

  • Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity

    Jacinta Bustamante;Jacinta Bustamante;Jacinta Bustamante;Stéphanie Boisson-Dupuis;Laurent Abel;Jean-Laurent Casanova

  • Whole-genome sequencing is more powerful than whole-exome sequencing for detecting exome variants.

    Aziz Belkadi;Alexandre Bolze;Yuval Itan;Aurélie Cobat;Aurélie Cobat

  • Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I

    Anne Puel;Anne Puel;Rainer Döffinger;Angels Natividad;Angels Natividad;Maya Chrabieh;Maya Chrabieh

  • IRF8 mutations and human dendritic-cell immunodeficiency.

    Sophie Hambleton;Sandra Salem;Jacinta Bustamante;Venetia Bigley

  • Susceptibility to leprosy is associated with PARK2 and PACRG.

    Marcelo T. Mira;Marcelo T. Mira;Alexandre Alcaïs;Nguyen Van Thuc;Milton O. Moraes

  • Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths.

    Paul Bastard;Adrian Gervais;Adrian Gervais;Tom Le Voyer;Tom Le Voyer;Jérémie Rosain;Jérémie Rosain

  • Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 Deficiency

    Dusan Bogunovic;Minji Byun;Larissa A. Durfee;Avinash Abhyankar

  • Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

    Xianqin Zhang;Dusan Bogunovic;Béatrice Payelle-Brogard;Véronique Francois-Newton

  • Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells

    Ludovic de Beaucoudrey;Ludovic de Beaucoudrey;Anne Puel;Anne Puel;Orchidée Filipe-Santos;Orchidée Filipe-Santos;Aurélie Cobat;Aurélie Cobat

  • Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

    Capucine Picard;Capucine Picard;Horst Von Bernuth;Horst Von Bernuth;Horst Von Bernuth;Pegah Ghandil;Pegah Ghandil;Pegah Ghandil;Maya Chrabieh;Maya Chrabieh

Frequent Co-Authors

Jean-Laurent Casanova
Jean-Laurent Casanova The University of Texas Southwestern Medical Center
Stéphanie Boisson-Dupuis
Stéphanie Boisson-Dupuis Université Paris Cité
Aurélie Cobat
Aurélie Cobat Grenoble Alpes University
Jacinta Bustamante
Jacinta Bustamante Rockefeller University
Emmanuelle Jouanguy
Emmanuelle Jouanguy Necker-Enfants Malades Hospital
Capucine Picard
Capucine Picard Université Paris Cité
Shen-Ying Zhang
Shen-Ying Zhang Rockefeller University
Erwin Schurr
Erwin Schurr McGill University Health Centre
Bertrand Boisson
Bertrand Boisson Rockefeller University

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