World's Best Scientists 2026 revealed!

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Genetics

D-Index
69
Citations
20044
World Ranking
2334
National Ranking
1054

Overview

Ethan M. Lange is affiliated with the University of Colorado Anschutz Medical Campus in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in Genetics and Molecular Biology subfields.

Their scholarly work emphasizes several main topics including:

  • Genetic Associations and Epidemiology
  • Epigenetics and DNA Methylation
  • Birth, Development, and Health
  • Prostate Cancer Treatment and Research
  • Genetic and phenotypic traits in livestock
  • Genetic Mapping and Diversity in Plants and Animals
  • Adipokines, Inflammation, and Metabolic Diseases

Among their recent research papers are:

  • Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data (2022, Nature Genetics)
  • Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease (2023, Nature Communications)
  • Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci (2021, Genome Medicine)
  • DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function (2021, Clinical Epigenetics)
  • Circulating Soluble CD163, Associations With Cardiovascular Outcomes and Mortality, and Identification of Genetic Variants in Older Individuals: The Cardiovascular Health Study (2022, Journal of the American Heart Association)

Frequently publishing in venues such as UNC Libraries, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Zenodo (CERN European Organization for Nuclear Research), and Circulation, their work appears consistently in both preprint and peer-reviewed journals.

Frequent collaborators in their research include:

  • Leslie A. Lange
  • Laura M. Raffield (31 co-authored papers)
  • Stephen S. Rich (25 co-authored papers)
  • Jerome I. Rotter (22 co-authored papers)

This body of work reflects a sustained focus on genetic and molecular mechanisms related to human health, with applications to cardiovascular, renal, and developmental biology. The scientist's contributions span epidemiological genetics and molecular studies aimed at understanding complex traits and disease associations across diverse populations.

Best Publications

  • REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants

    Nilah M M. Ioannidis;Joseph H H. Rothstein;Joseph H H. Rothstein;Vikas Pejaver;Sumit Middha

  • Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

    Ron Do;Ron Do;Nathan O. Stitziel;Hong Hee Won;Hong Hee Won;Anders Berg Jørgensen

  • Inherited causes of clonal haematopoiesis in 97,691 whole genomes.

    Alexander G Bick;Joshua S Weinstock;Satish K Nandakumar;Satish K Nandakumar;Charles P Fulco;Charles P Fulco

  • Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

    Rosalind A. Eeles;Ali Amin Al Olama;Sara Benlloch;Edward J. Saunders

  • Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

    Rosalind A. Eeles;Zsofia Kote-Jarai;Ali Amin Al Olama;Graham G. Giles;Graham G. Giles

  • Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk

    Jianfeng Xu;S. Lilly Zheng;Akira Komiya;Josyf C. Mychaleckyj

  • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

    Valérie Turcot;Yingchang Lu;Yingchang Lu;Heather M Highland;Heather M Highland;Claudia Schurmann

  • Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events.

    Leslie A. Lange;Christopher S. Carlson;Lucia A. Hindorff;Ethan M. Lange

  • Genetic modifiers of liver disease in cystic fibrosis.

    Jaclyn R. Bartlett;Kenneth J. Friedman;Simon C. Ling;Rhonda G. Pace

  • The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes.

    Soumitra Ghosh;Richard M. Watanabe;Timo T. Valle;Elizabeth R. Hauser

  • Prostate Cancer Susceptibility Locus on Chromosome 1q: A Confirmatory Study

    K.A. Cooney;J.D. McCarthy;E. Lange;L. Huang

  • Exploring the genetic basis of chronic periodontitis: a genome-wide association study

    Kimon Divaris;Keri L. Monda;Keri L. Monda;Kari E North;Andrew F Olshan

  • Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2.

    Fred A. Wright;Lisa J. Strug;Vishal K. Doshi;Clayton W. Commander

  • Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level

    A. J. Szalai;A. J. Szalai;J. Wu;E. M. Lange;M. A. McCrory

  • Randomized comparison of prophylactic and minimal residual disease-triggered imatinib after allogeneic stem cell transplantation for BCR-ABL1-positive acute lymphoblastic leukemia.

    Pfeifer H;Wassmann B;Bethge W;Dengler J

  • Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

    Leslie A Lange;Youna Hu;He Zhang;Chenyi Xue

  • HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG)

    Jianfeng Xu;Ethan M. Lange;Ethan M. Lange;Lingyi Lu;Siqun L. Zheng

  • Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer

    Tasha R. Smith;Mark Steven Miller;Kurt Lohman;Ethan M. Lange

  • Rare and low-frequency coding variants alter human adult height

    Eirini Marouli;Mariaelisa Graff;Carolina Medina-Gomez;Ken Sin Lo

  • Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

    Jennifer Wessel;Audrey Y. Chu;Sara M. Willems;Shuai Wang

Frequent Co-Authors

Leslie A. Lange
Leslie A. Lange University of Colorado Anschutz Medical Campus
Alexander P. Reiner
Alexander P. Reiner University of Washington
James G. Wilson
James G. Wilson University of Mississippi Medical Center
Eric Boerwinkle
Eric Boerwinkle The University of Texas Health Science Center at Houston
Kari E. North
Kari E. North University of North Carolina at Chapel Hill
Jianfeng Xu
Jianfeng Xu Arkansas State University
Karen L. Mohlke
Karen L. Mohlke University of North Carolina at Chapel Hill
William B. Isaacs
William B. Isaacs Johns Hopkins University
Graham G. Giles
Graham G. Giles University of Melbourne
Elaine A. Ostrander
Elaine A. Ostrander National Institutes of Health

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