World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
86
Citations
35169
World Ranking
1241
National Ranking
588

Medicine

D-Index
88
Citations
36353
World Ranking
12979
National Ranking
6635

Overview

Leslie A. Lange is affiliated with the University of Colorado Anschutz Medical Campus in the United States. Their research portfolio spans multiple domains primarily within biochemistry, genetics, molecular biology, and medicine. With a focus on genetics and molecular biology, they have contributed to advancing understanding in a variety of related subfields including pediatrics, perinatology, child health, cardiology, cardiovascular medicine, and public health.

Their work centers on several main research topics such as genetic associations and epidemiology, birth, development and health, epigenetics and DNA methylation, bioinformatics and genomic networks, chronic obstructive pulmonary disease (COPD) research, nutrition genetics and disease, and genomics and rare diseases. This range indicates a comprehensive engagement with both fundamental genetic mechanisms and their implications for health and disease across populations.

Leslie A. Lange has been involved in a significant number of publications, with frequent appearances in venues like UNC Libraries, bioRxiv (Cold Spring Harbor Laboratory), Circulation, PLoS ONE, and Nature Communications. These venues highlight a mixture of open-access preprint platforms and peer-reviewed journals that cover diverse aspects of biomedical research.

  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Circulation
  • PLoS ONE
  • Nature Communications

The scientist has collaborated with a number of frequent co-authors including Stephen S. Rich, Laura M. Raffield, Jerome I. Rotter, Bruce M. Psaty, and Ethan M. Lange. These collaborations reflect ongoing partnerships in genetic and medical research communities.

  • Stephen S. Rich
  • Laura M. Raffield
  • Jerome I. Rotter
  • Bruce M. Psaty
  • Ethan M. Lange

Notable recent publications illustrate the scope and impact of their research. These include:

  • "Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program," 2021, Nature
  • "The Polygenic and Monogenic Basis of Blood Traits and Diseases," 2020, Cell
  • "Association of clonal hematopoiesis with chronic obstructive pulmonary disease," 2021, Blood
  • "Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals," 2023, Nature Genetics
  • "Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes," 2021, Nature Communications

These publications detail work related to large-scale genomic sequencing, genetic bases of blood traits and diseases, links between genetic mutations and chronic diseases such as COPD, and ancestry-related influences on genetic variation effects. The diversity of venues and high citation counts reflect visibility and engagement in contemporary biomedical research.

Best Publications

  • Biological, clinical and population relevance of 95 loci for blood lipids

    Tanya M. Teslovich;Kiran Musunuru;Albert V. Smith;Andrew C. Edmondson

  • Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.

    Daniel Taliun;Daniel N. Harris;Michael D. Kessler;Jedidiah Carlson;Jedidiah Carlson

  • The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.

    D I Swerdlow;M V Holmes;K B Kuchenbaecker

  • Loss-of-function mutations in APOC3, triglycerides, and coronary disease

    Jacy Crosby;Gina M. Peloso;Gina M. Peloso;Paul L. Auer;David R. Crosslin

  • Association between alcohol and cardiovascular disease:Mendelian randomisation analysis based on individual participant data

    Michael V Holmes;Michael V Holmes;Caroline E Dale;Luisa Zuccolo;Richard J Silverwood

  • The trans-ancestral genomic architecture of glycemic traits

    Ji Chen;Ji Chen;Cassandra N. Spracklen;Cassandra N. Spracklen;Gaëlle Marenne;Gaëlle Marenne;Arushi Varshney

  • HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.

    Daniel I Swerdlow;David Preiss;Karoline B Kuchenbaecker;Michael Holmes

  • Mendelian randomization of blood lipids for coronary heart disease

    Michael V. Holmes;Folkert W. Asselbergs;Tom M. Palmer;Fotios Drenos

  • Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

    Ron Do;Ron Do;Nathan O. Stitziel;Hong Hee Won;Hong Hee Won;Anders Berg Jørgensen

  • Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data

    G. Eiriksdottir;T. B. Harris;L. J. Launer;V. Gudnason

  • Inherited causes of clonal haematopoiesis in 97,691 whole genomes.

    Alexander G Bick;Joshua S Weinstock;Satish K Nandakumar;Satish K Nandakumar;Charles P Fulco;Charles P Fulco

  • The polygenic and monogenic basis of blood traits and diseases

    Dragana Vuckovic;Erik L. Bao;Parsa Akbari;Caleb A. Lareau

  • Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.

    Ming-Huei Chen;Laura M Raffield;Abdou Mousas;Saori Sakaue

  • Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

    Z Dastani;Hivert M-F.;Hivert M-F.;N Timpson;Perry Jrb.;Perry Jrb.

  • Inactivating mutations in NPC1L1 and protection from coronary heart disease

    Nathan O. Stitziel;Hong Hee Won;Alanna C. Morrison;Gina M. Peloso

  • Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

    Daniel Taliun;Daniel N. Harris;Michael D. Kessler;Jedidiah Carlson;Jedidiah Carlson

  • Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

    Anubha Mahajan;Jennifer Wessel;Sara M. Willems;Wei Zhao

  • Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.

    Gina M. Peloso;Paul L. Auer;Joshua C. Bis;Arend Voorman

  • Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events.

    Leslie A. Lange;Christopher S. Carlson;Lucia A. Hindorff;Ethan M. Lange

  • The Polygenic and Monogenic Basis of Blood Traits and Diseases

    Dragana Vuckovic;Dragana Vuckovic;Erik L. Bao;Erik L. Bao;Parsa Akbari;Caleb A. Lareau;Caleb A. Lareau

Frequent Co-Authors

Alexander P. Reiner
Alexander P. Reiner University of Washington
Bruce M. Psaty
Bruce M. Psaty University of Washington
James G. Wilson
James G. Wilson University of Mississippi Medical Center
Ethan M. Lange
Ethan M. Lange University of Colorado Anschutz Medical Campus
Jerome I. Rotter
Jerome I. Rotter UCLA Medical Center
Eric Boerwinkle
Eric Boerwinkle The University of Texas Health Science Center at Houston
Stephen S. Rich
Stephen S. Rich University of Virginia
Albert V. Smith
Albert V. Smith University of Michigan–Ann Arbor
L. Adrienne Cupples
L. Adrienne Cupples Boston University
Karen L. Mohlke
Karen L. Mohlke University of North Carolina at Chapel Hill

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