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Medicine

D-Index
143
Citations
87969
World Ranking
1495
National Ranking
868

Overview

William B. Isaacs is affiliated with Johns Hopkins University in the United States. Their research spans multiple domains within medicine, biochemistry, genetics, and molecular biology, with a particular concentration on prostate cancer treatment and research.

Their scholarly output includes significant contributions to prostate cancer diagnosis and treatment, as well as genetic associations and epidemiology. The scientist's work also touches on cancer genomics and diagnostics, cancer biology related to lipids and metabolism, cancer-related gene regulation, and genetic factors influencing colorectal cancer.

Isaacs has published extensively in notable venues, including:

  • UNC Libraries
  • The Prostate
  • European Urology
  • Journal of Clinical Oncology
  • European Urology Open Science

Frequent collaborators in their body of work include:

  • Jianfeng Xu
  • Kathleen A. Cooney
  • Brian T. Helfand
  • Elaine A. Ostrander
  • Zhuqing Shi

The following recent papers illustrate the scope and focus of Isaacs's research:

  • Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019 (2020), published in Journal of Clinical Oncology
  • Homologous recombination deficiency (HRD) score in germline BRCA2- versus ATM-altered prostate cancer (2021), published in Modern Pathology
  • Role of androgen receptor splice variant-7 (AR-V7) in prostate cancer resistance to 2nd-generation androgen receptor signaling inhibitors (2020), published in Oncogene
  • Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy (2020), published in Nature Communications
  • Rare Germline Variants in ATM Predispose to Prostate Cancer: A PRACTICAL Consortium Study (2021), published in European Urology Oncology

Their research topics fall within several subfields of medicine and biosciences, prominently including pulmonary and respiratory medicine, genetics, cancer research, molecular biology, and pathology and forensic medicine.

Overall, William B. Isaacs's body of work reflects research activity primarily focused on prostate cancer biology, genetics, diagnosis, and treatment, as well as related molecular mechanisms.

Best Publications

  • Overexpression of Hypoxia-inducible Factor 1α in Common Human Cancers and Their Metastases

    Hua Zhong;Angelo M. De Marzo;Erik Laughner;Michael Lim

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants

    Nilah M M. Ioannidis;Joseph H H. Rothstein;Joseph H H. Rothstein;Vikas Pejaver;Sumit Middha

  • AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer.

    Emmanuel S. Antonarakis;Changxue Lu;Hao Wang;Brandon Luber

  • Inflammation in prostate carcinogenesis

    Angelo M. De Marzo;Angelo M. De Marzo;Elizabeth A. Platz;Siobhan Sutcliffe;Jianfeng Xu

  • Mutations of the VHL tumour suppressor gene in renal carcinoma

    J.R. Gnarra;K. Tory;Y. Weng;L. Schmidt

  • DD3::A New Prostate-specific Gene, Highly Overexpressed in Prostate Cancer

    M.J.G. Bussemakers;A. van Bokhoven;G.W.C.T. Verhaegh;F.P. Smit

  • The evolutionary history of lethal metastatic prostate cancer.

    Gunes Gundem;Peter Van Loo;Peter Van Loo;Peter Van Loo;Barbara Kremeyer;Ludmil B. Alexandrov

  • Ligand-Independent Androgen Receptor Variants Derived from Splicing of Cryptic Exons Signify Hormone-Refractory Prostate Cancer

    Rong Hu;Thomas A. Dunn;Shuanzeng Wei;Sumit Isharwal

  • E-Cadherin Expression Is Silenced by DNA Hypermethylation in Human Breast and Prostate Carcinomas

    Jeremy R. Graff;James G. Herman;Rena G. Lapidus;Hemi Chopra

  • Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis

    Wen-Hsiang Lee;R. A. Morton;J. I. Epstein;J. D. Brooks

  • Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search

    Jeffrey R. Smith;Diha Freije;John D. Carpten;Henrik Grönberg;Henrik Grönberg

  • Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

    Julius Gudmundsson;Patrick Sulem;Andrei Manolescu;Laufey T Amundadottir

  • Frequent Inactivation of PTEN/MMAC1 in Primary Prostate Cancer

    P Cairns;K Okami;S Halachmi;N Halachmi

  • DPC4 Gene in Various Tumor Types

    Mieke Schutte;Ralph H. Hruban;Lora Hedrick;Kathleen R. Cho

  • Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

    Young E. Whang;Xinyi Wu;Hiroyoshi Suzuki;Robert E. Reiter

  • Hereditary Prostate Cancer: Epidemiologic and Clinical Features

    Bob S. Carter;G. Steven Bova;Terri H. Beaty;Gary D. Steinberg

  • Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer.

    Umbas R;Schalken Ja;Aalders Tw;Carter Bs

  • Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

    P. Cairns;T. J. Polascik;Y. Eby;K. Tokino

  • The evolutionary history of lethal metastatic prostate cancer

    G Gundem;P Van Loo;B Kremeyer;L B Alexandrov

Frequent Co-Authors

Jianfeng Xu
Jianfeng Xu Arkansas State University
Patrick C. Walsh
Patrick C. Walsh Johns Hopkins University
Henrik Grönberg
Henrik Grönberg Karolinska Institute
Angelo M. De Marzo
Angelo M. De Marzo Johns Hopkins University School of Medicine
John D. Carpten
John D. Carpten University of Southern California
Fredrik Wiklund
Fredrik Wiklund Karolinska Institute
Elizabeth A. Platz
Elizabeth A. Platz Johns Hopkins University
William G. Nelson
William G. Nelson Johns Hopkins University School of Medicine
Janet L. Stanford
Janet L. Stanford Fred Hutchinson Cancer Research Center
Deborah A. Meyers
Deborah A. Meyers University of Arizona

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