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Biology and Biochemistry

D-Index
73
Citations
19491
World Ranking
5921
National Ranking
2801

Overview

Norbert Leitinger is affiliated with the University of Virginia in the United States, with a research profile encompassing biochemistry, genetics, molecular biology, and medicine. Their work focuses particularly on molecular biology, immunology, physiology, cardiology and cardiovascular medicine, and cell biology.

The scientist's research covers several main topics including:

  • Connexins and lens biology
  • Peroxisome Proliferator-Activated Receptors
  • Endoplasmic Reticulum Stress and Disease
  • Adipose Tissue and Metabolism
  • Mitochondrial Function and Pathology
  • Liver Disease Diagnosis and Treatment
  • Diabetes and associated disorders

Norbert Leitinger has contributed articles to multiple publication venues, with frequent appearances in:

  • Free Radical Biology and Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Circulation Research
  • The FASEB Journal
  • Science Advances

Among the recent papers authored or coauthored by Leitinger are:

  • Innate immune signaling in Drosophila shifts anabolic lipid metabolism from triglyceride storage to phospholipid synthesis to support immune function, 2020, PLoS Genetics
  • Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism, 2022, Science Advances
  • Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development, 2020, Nature Communications
  • Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis, 2022, Science Advances
  • Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2, 2020, eLife

Leitinger's collaborations include frequent coauthors such as:

  • Clint M. Upchurch
  • Scott Yeudall
  • Caitlin Pavelec
  • Brant E. Isakson
  • Matthew J. Wolf

Best Publications

  • Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

    Michael R. Elliott;Faraaz B. Chekeni;Paul C. Trampont;Eduardo R. Lazarowski

  • Structural Identification by Mass Spectrometry of Oxidized Phospholipids in Minimally Oxidized Low Density Lipoprotein That Induce Monocyte/Endothelial Interactions and Evidence for Their Presence in Vivo

    Andrew D. Watson;Norbert Leitinger;Mohamad Navab;Kym F. Faull

  • Lipid Oxidation Products Have Opposite Effects on Calcifying Vascular Cell and Bone Cell Differentiation A Possible Explanation for the Paradox of Arterial Calcification in Osteoporotic Patients

    Farhad Parhami;Andrew D. Morrow;Jennifer Balucan;Norbert Leitinger

  • Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins.

    Sohvi Hörkkö;David A. Bird;Elizabeth Miller;Hiroyuki Itabe

  • Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2

    Alexandra Kadl;Akshaya K. Meher;Poonam R. Sharma;Monica Y. Lee

  • The role of oxidized phospholipids in atherosclerosis

    Judith A. Berliner;Norbert Leitinger;Sotirios Tsimikas

  • Polyunsaturated eicosapentaenoic acid displaces proteins from membrane rafts by altering raft lipid composition.

    Thomas M. Stulnig;Joakim Huber;Norbert Leitinger;Esther-Maria Imre

  • Protective role of phospholipid oxidation products in endotoxin-induced tissue damage

    Valery N. Bochkov;Alexandra Kadl;Joakim Huber;Florian Gruber

  • Induction of Heme Oxygenase-1 Inhibits the Monocyte Transmigration Induced by Mildly Oxidized LDL

    Kazunobu Ishikawa;Mohamad Navab;Norbert Leitinger;Alan M. Fogelman

  • Oxidized Membrane Vesicles and Blebs From Apoptotic Cells Contain Biologically Active Oxidized Phospholipids That Induce Monocyte-Endothelial Interactions

    Joakim Huber;Anja Vales;Goran Mitulovic;Michael Blumer

  • Determinants of bioactivity of oxidized phospholipids. Specific oxidized fatty acyl groups at the sn-2 position.

    Ganesamoorthy Subbanagounder;Norbert Leitinger;Dawn C. Schwenke;Jason W. Wong

  • Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils

    Norbert Leitinger;Timothy R. Tyner;Laura Oslund;Cristina Rizza

  • Phenotypic Polarization of Macrophages in Atherosclerosis

    Norbert Leitinger;Ira G. Schulman

  • Oxidized Phospholipids Induce Phenotypic Switching of Vascular Smooth Muscle Cells In Vivo and In Vitro

    Nataliya A. Pidkovka;Olga A. Cherepanova;Tadashi Yoshida;Matthew R. Alexander

  • Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

    Sho Morioka;Justin S. A. Perry;Michael H. Raymond;Christopher B. Medina

  • Expression of Heme Oxygenase-1 in Human Vascular Cells Is Regulated by Peroxisome Proliferator-Activated Receptors

    Gerhard Krönke;Alexandra Kadl;Elena Ikonomu;Stefan Blüml

  • Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT.

    Valery N. Bochkov;Diana Mechtcheriakova;Marcus Lucerna;Joakim Huber

  • Evidence for a role of phospholipid oxidation products in atherogenesis.

    Judith A. Berliner;Ganesamoorthy Subbanagounder;Norbert Leitinger;Andrew D. Watson

  • cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

    Nagaraj Kerur;Nagaraj Kerur;Shinichi Fukuda;Shinichi Fukuda;Daipayan Banerjee;Daipayan Banerjee;Younghee Kim;Younghee Kim

  • Oxidized Phospholipids Induce Expression of Human Heme Oxygenase-1 Involving Activation of cAMP-responsive Element-binding Protein

    Gerhard Krönke;Valery N. Bochkov;Joakim Huber;Florian Gruber

Frequent Co-Authors

Brant E. Isakson
Brant E. Isakson University of Virginia
Gerhard Krönke
Gerhard Krönke Charité - University Medicine Berlin
Bernd R. Binder
Bernd R. Binder Medical University of Vienna
Judith A. Berliner
Judith A. Berliner University of California, Los Angeles
Kodi S. Ravichandran
Kodi S. Ravichandran University of Virginia
Gary K. Owens
Gary K. Owens University of Virginia
Gilbert R. Upchurch
Gilbert R. Upchurch University of Florida
Valery N. Bochkov
Valery N. Bochkov University of Graz
Konstantin G. Birukov
Konstantin G. Birukov University of Chicago
Douglas A. Bayliss
Douglas A. Bayliss University of Virginia

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