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Best Scientists
2025

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Best Scientists

D-Index
171
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118081
World Ranking
834
National Ranking
501

Medicine

D-Index
173
Citations
122942
World Ranking
476
National Ranking
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Research.com Recognitions

  • 2025 - Research.com Best Scientists Award

Overview

Joseph L. Witztum is affiliated with the University of California, San Diego in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology, with a significant focus on lipid metabolism and cardiovascular health.

Witztum's work encompasses a range of topics, prominently including:

  • Lipid metabolism and disorders
  • Lipoproteins and cardiovascular health
  • Atherosclerosis and cardiovascular diseases
  • Cancer, lipids, and metabolism
  • Diabetes, cardiovascular risks, and lipoproteins
  • Liver disease diagnosis and treatment
  • Metabolism, diabetes, and cancer

The scientist has contributed extensively to fields such as immunology, cardiology and cardiovascular medicine, molecular biology, surgery, and endocrinology, diabetes, and metabolism. Their publication record includes 102 articles classified under medicine and 52 under biochemistry and molecular biology.

Frequent publication venues for Witztum's research include:

  • Journal of Clinical Lipidology
  • Atherosclerosis
  • Journal of the American College of Cardiology
  • Journal of Lipid Research
  • Circulation

Co-authorship has been a significant aspect of Witztum's scientific work, often collaborating with researchers such as:

  • Sotirios Tsimikas (42 joint publications)
  • Shuting Xia (15 joint publications)
  • Ewa Karwatowska-Prokopczuk (14 joint publications)
  • Veronica Alexander (12 joint publications)
  • Daniel Gaudet (11 joint publications)

Among notable research papers, several stand out for their impact and relevance, including:

  • Lipoprotein(a) Reduction in Persons with Cardiovascular Disease, 2020, published in New England Journal of Medicine
  • Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors, 2021, Immunity
  • Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis, 2020, Immunity
  • An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis, 2020, Science
  • Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia, 2020, European Heart Journal

Best Publications

  • Atherosclerosis: The Road Ahead

    Christopher K. Glass;Joseph L. Witztum

  • A comprehensive classification system for lipids

    Eoin Fahy;Shankar Subramaniam;H. Alex Brown;Christopher K. Glass

  • Role of oxidized low density lipoprotein in atherogenesis.

    J L Witztum;D Steinberg

  • Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

    Seppo Yla-Herttuala;Wulf Palinski;Michael E. Rosenfeld;Sampath Parthasarathy

  • Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids

    Urs P. Steinbrecher;Sampath Parthasarathy;David S. Leake;Joseph L. Witztum

  • The oxidation hypothesis of atherosclerosis

    J.L Witztum

  • Low density lipoprotein undergoes oxidative modification in vivo

    Wulf Palinski;Michael E. Rosenfeld;Seppo Yla-Herttuala;Geoff C. Gurtner

  • Autoantibody against oxidised LDL and progression of carotid atherosclerosis.

    Salonen Jt;Ylä-Herttuala S;Yamamoto R;Butler S

  • Lipoprotein Management in Patients With Cardiometabolic Risk: Consensus Conference Report From the American Diabetes Association and the American College of Cardiology Foundation

    John D. Brunzell;Michael Davidson;Curt D. Furberg;Ronald B. Goldberg

  • Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology Foundation.

    John D. Brunzell;Michael Davidson;Curt D. Furberg;Ronald B. Goldberg

  • Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions.

    Claudio Napoli;Francesco Paolo D'Armiento;Francesco Paolo Mancini;Alfredo Postiglione

  • T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein.

    Sten Stemme;Beata Faber;Jan Holm;Olov Wiklund

  • Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions.

    Seppo Ylä-Herttuala;Beth A. Lipton;Michael E. Rosenfeld;Terttu Särkioja

  • Structural Identification by Mass Spectrometry of Oxidized Phospholipids in Minimally Oxidized Low Density Lipoprotein That Induce Monocyte/Endothelial Interactions and Evidence for Their Presence in Vivo

    Andrew D. Watson;Norbert Leitinger;Mohamad Navab;Kym F. Faull

  • Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase

    Jannet T. Huang;John S. Welch;Mercedes Ricote;Christoph J. Binder

  • Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein

    Mercedes Ricote;Jannet Huang;Luis Fajas;Andrew Li

  • Oxidized Phospholipids, Lp(a) Lipoprotein, and Coronary Artery Disease

    Sotirios Tsimikas;Emmanouil S. Brilakis;Elizabeth R. Miller;Joseph P. McConnell

  • Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL.

    Christoph J Binder;Sohvi Hörkkö;Sohvi Hörkkö;Asheesh Dewan;Mi-Kyung Chang

  • IMMUNIZATION OF LOW DENSITY LIPOPROTEIN (LDL) RECEPTOR-DEFICIENT RABBITS WITH HOMOLOGOUS MALONDIALDEHYDE-MODIFIED LDL REDUCES ATHEROGENESIS

    Wulf Palinski;Elizabeth Miller;Joseph L. Witztum

  • Role of oxidised low density lipoprotein in atherogenesis

    Joseph L Witztum

Frequent Co-Authors

Sotirios Tsimikas
Sotirios Tsimikas University of California, San Diego
Christoph J. Binder
Christoph J. Binder Medical University of Vienna
Wulf Palinski
Wulf Palinski University of California, San Diego
Linda K. Curtiss
Linda K. Curtiss Scripps Research Institute
Daniel Steinberg
Daniel Steinberg University of California, San Diego
Yury I. Miller
Yury I. Miller University of California, San Diego
Gustav Schonfeld
Gustav Schonfeld Washington University in St. Louis
Edward A. Dennis
Edward A. Dennis University of California, San Diego
Christopher K. Glass
Christopher K. Glass University of California, San Diego
Stephen G. Young
Stephen G. Young University of California, Los Angeles

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