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Seppo Ylä-Herttuala

Seppo Ylä-Herttuala

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Biology and Biochemistry
Finland
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
144
Citations
76309
World Ranking
228
National Ranking
2

Medicine

D-Index
144
Citations
76349
World Ranking
1446
National Ranking
17

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Finland Leader Award
  • 2025 - Research.com Biology and Biochemistry in Finland Leader Award
  • 2023 - Research.com Biology and Biochemistry in Finland Leader Award
  • 2022 - Research.com Biology and Biochemistry in Finland Leader Award

Overview

Seppo Ylä-Herttuala is affiliated with the University of Eastern Finland in Finland and has a research portfolio primarily focused on medicine and biochemistry, genetics, and molecular biology.

Their work spans several subfields, including molecular biology, surgery, cardiology and cardiovascular medicine, genetics, and cancer research.

Main research topics include virus-based gene therapy research, angiogenesis and VEGF in cancer, CAR-T cell therapy research, atherosclerosis and cardiovascular diseases, cancer-related molecular mechanisms, bladder and urothelial cancer treatments, and microRNA in disease regulation.

Frequent co-authors in their research include Minna U. Kaikkonen, Johanna P. Laakkonen, Nihay Laham-Karam, Tiit Örd, and Juha Hartikainen.

Their publications are often featured in several notable venues. The most frequent publication venues are:

  • European Heart Journal
  • Scientific Reports
  • Human Gene Therapy
  • Arteriosclerosis Thrombosis and Vascular Biology
  • The Journal of Urology

Selected recent papers authored or co-authored by Seppo Ylä-Herttuala include:

  • "Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics" (2020) published in Circulation Research
  • "Intravesical nadofaragene firadenovec gene therapy for BCG-unresponsive non-muscle-invasive bladder cancer: a single-arm, open-label, repeat-dose clinical trial" (2020) published in The Lancet Oncology
  • "BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF" (2020) published in Angiogenesis
  • "Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci" (2021) published in Circulation Research
  • "MicroRNA-15b Targets VEGF and Inhibits Angiogenesis in Proliferative Diabetic Retinopathy" (2020) published in The Journal of Clinical Endocrinology & Metabolism

Best Publications

  • Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

    Seppo Yla-Herttuala;Wulf Palinski;Michael E. Rosenfeld;Sampath Parthasarathy

  • Low density lipoprotein undergoes oxidative modification in vivo

    Wulf Palinski;Michael E. Rosenfeld;Seppo Yla-Herttuala;Geoff C. Gurtner

  • Autoantibody against oxidised LDL and progression of carotid atherosclerosis.

    Salonen Jt;Ylä-Herttuala S;Yamamoto R;Butler S

  • Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions.

    Seppo Ylä-Herttuala;Beth A. Lipton;Michael E. Rosenfeld;Terttu Särkioja

  • Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.

    Taija Mäkinen;Lotta Jussila;Tanja Veikkola;Terhi Karpanen

  • Vascular Endothelial Growth Factor C Promotes Tumor Lymphangiogenesis and Intralymphatic Tumor Growth

    Terhi Karpanen;Mikala Egeblad;Marika J. Karkkainen;Hajime Kubo

  • Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

    Tuomas Tammela;Georgia Zarkada;Elisabet Wallgard;Aino Murtomäki

  • Safety and Feasibility of Catheter-Based Local Intracoronary Vascular Endothelial Growth Factor Gene Transfer in the Prevention of Postangioplasty and In-Stent Restenosis and in the Treatment of Chronic Myocardial Ischemia Phase II Results of the Kuopio Angiogenesis Trial (KAT)

    Marja Hedman;Juha Hartikainen;Mikko Syvänne;Joachim Stjernvall

  • Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor

    Tatiana V. Petrova;Taija Mäkinen;Tomi P. Mäkelä;Janna Saarela

  • Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL.

    S Ylä-Herttuala;W Palinski;S W Butler;S Picard

  • Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein.

    Wulf Palinski;Seppo Ylä-Herttuala;Michael E. Rosenfeld;Susan W. Butler

  • Suppression of Tumor Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling

    Yulong He;Ken Ichi Kozaki;Terhi Karpanen;Katsumi Koshikawa

  • A model for gene therapy of human hereditary lymphedema

    Marika J. Karkkainen;Anne Saaristo;Lotta Jussila;Kaisa A. Karila

  • Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.

    M E Rosenfeld;W Palinski;S Ylä-Herttuala;S Butler

  • Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation

    Peter Baluk;Tuomas Tammela;Erin Ator;Natalya Lyubynska

  • Biology of vascular endothelial growth factors

    Himadri Roy;Shalini Bhardwaj;Seppo Ylä-Herttuala

  • Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine.

    Seppo Ylä-Herttuala;Tuomas T. Rissanen;Ismo Vajanto;Juha Hartikainen

  • History of gene therapy

    Thomas Wirth;Nigel Parker;Seppo Ylä-Herttuala

  • Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis

    Tatiana V Petrova;Terhi Karpanen;Camilla Norrmén;Russell Mellor

  • Human gene therapy

    Ylä-Herttuala S;Ollikainen A;Vapalahti M

Frequent Co-Authors

Kari Alitalo
Kari Alitalo University of Helsinki
Juhani Knuuti
Juhani Knuuti Turku University Hospital
Mikko Hiltunen
Mikko Hiltunen University of Eastern Finland
Anna-Liisa Levonen
Anna-Liisa Levonen University of Eastern Finland
Tuomas Tammela
Tuomas Tammela Memorial Sloan Kettering Cancer Center
Olli Gröhn
Olli Gröhn University of Eastern Finland
Markku S. Kulomaa
Markku S. Kulomaa Tampere University
Veli-Matti Kosma
Veli-Matti Kosma University of Eastern Finland
Markku Laakso
Markku Laakso University of Eastern Finland
Joseph L. Witztum
Joseph L. Witztum University of California, San Diego

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