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D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
14290
World Ranking
6800
National Ranking
517

Overview

Jane Clarke is affiliated with the University of Cambridge in the United Kingdom. Their research spans multiple fields with a strong focus on biochemistry, genetics, and molecular biology, complemented by contributions to materials science. This multidisciplinary approach is reflected in their work on molecular biology and polymers and plastics, as well as related subfields such as endocrinology, diabetes and metabolism, atomic and molecular physics and optics, and civil and structural engineering.

Their research topics cover a diverse range, including polymer nanocomposites and properties, RNA and protein synthesis mechanisms, force microscopy techniques and applications, polymer crystallization and properties, growth hormone and insulin-like growth factors, bacterial genetics and biotechnology, and chemical synthesis and analysis.

Notable recent publications by Jane Clarke include:

  • The folding and unfolding behavior of ribonuclease H on the ribosome, 2020, Journal of Biological Chemistry
  • Selective Affimers Recognise the BCL-2 Family Proteins BCL-xL and MCL-1 through Noncanonical Structural Motifs, 2020, ChemBioChem
  • Effect of SiO2 Particles on the Relaxation Dynamics of Epoxidized Natural Rubber (ENR) in the Melt State by Time-Resolved Mechanical Spectroscopy, 2021, Polymers
  • Structure Evolution of Epoxidized Natural Rubber (ENR) in the Melt State by Time-Resolved Mechanical Spectroscopy, 2020, Materials
  • Disorder in a two-domain neuronal Ca2+-binding protein regulates domain stability and dynamics using ligand mimicry, 2020, Cellular and Molecular Life Sciences

Frequent co-authors collaborating with Jane Clarke in several publications include Madeleine K. Jensen, Avi J. Samelson, Annette Steward, Susan Marqusee, and Rossella Arrigo.

Their work is published in a variety of venues, with frequent publications appearing in UNC Libraries, Journal of Biological Chemistry, ChemBioChem, Cellular and Molecular Life Sciences, and Polymers.

Best Publications

  • Mechanical and Chemical Unfolding of a Single Protein: A Comparison

    Mariano Carrion-Vazquez;Andres F. Oberhauser;Susan B. Fowler;Piotr E. Marszalek

  • Engineered disulfide bonds as probes of the folding pathway of barnase: increasing the stability of proteins against the rate of denaturation.

    Jane Clarke;Alan R. Fersht

  • The folding and evolution of multidomain proteins.

    Jung-Hoon Han;Sarah Batey;Adrian A. Nickson;Sarah A. Teichmann

  • The importance of sequence diversity in the aggregation and evolution of proteins

    Caroline F. Wright;Sarah A. Teichmann;Jane Clarke;Christopher M. Dobson

  • Atomic force microscopy reveals the mechanical design of a modular protein

    Hongbin Li;Andres F. Oberhauser;Susan B. Fowler;Jane Clarke

  • Plasticity of an Ultrafast Interaction between Nucleoporins and Nuclear Transport Receptors

    Sigrid Milles;Davide Mercadante;Iker Valle Aramburu;Malene Ringkjøbing Jensen;Malene Ringkjøbing Jensen

  • Hidden complexity in the mechanical properties of titin

    Philip M. Williams;Susan B. Fowler;Robert B. Best;José Luis Toca-Herrera;José Luis Toca-Herrera

  • The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease.

    Mark Bycroft;Alex Bateman;Jane Clarke;Stefan J. Hamill

  • Mapping the Folding Pathway of an Immunoglobulin Domain: Structural Detail from Phi Value Analysis and Movement of the Transition State

    Susan B. Fowler;Jane Clarke

  • Can Non-Mechanical Proteins Withstand Force? Stretching Barnase by Atomic Force Microscopy and Molecular Dynamics Simulation

    Robert B. Best;Bin Li;Annette Steward;Valerie Daggett

  • The folding of an immunoglobulin-like Greek key protein is defined by a common-core nucleus and regions constrained by topology.

    Stefan J. Hamill;Annette Steward;Jane Clarke

  • Folding studies of immunoglobulin-like β-sandwich proteins suggest that they share a common folding pathway

    Jane Clarke;Ernesto Cota;Susan B Fowler;Stefan J Hamill

  • Mechanical Unfolding of a Titin Ig Domain: Structure of Unfolding Intermediate Revealed by Combining AFM, Molecular Dynamics Simulations, NMR and Protein Engineering

    Susan B Fowler;Robert B Best;José L Toca Herrera;Trevor J Rutherford

  • Towards a complete description of the structural and dynamic properties of the denatured state of barnase and the role of residual structure in folding

    Kam Bo Wong;Jane Clarke;Chris J. Bond;José Luis Neira

  • Parallel protein-unfolding pathways revealed and mapped.

    Caroline F Wright;Kresten Lindorff-Larsen;Lucy G Randles;Jane Clarke

  • Single-molecule fluorescence reveals sequence-specific misfolding in multidomain proteins

    Madeleine B. Borgia;Alessandro Borgia;Robert B. Best;Annette Steward

  • Experimental evidence for a frustrated energy landscape in a three-helix-bundle protein family

    Beth G. Wensley;Sarah Batey;Sarah Batey;Fleur A. C. Bone;Zheng Ming Chan

  • Mechanical Unfolding of a Titin Ig Domain: Structure of Transition State Revealed by Combining Atomic Force Microscopy, Protein Engineering and Molecular Dynamics Simulations

    Robert B. Best;Susan B. Fowler;José L. Toca Herrera;Annette Steward

  • Folding and stability of a fibronectin type III domain of human tenascin

    Jane Clarke;Stefan J Hamill;Christopher M Johnson

  • Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations.

    Fabian Paul;Fabian Paul;Christoph Wehmeyer;Esam T. Abualrous;Hao Wu

Frequent Co-Authors

Robert B. Best
Robert B. Best National Institutes of Health
Alan R. Fersht
Alan R. Fersht University of Cambridge
Stefan M.V. Freund
Stefan M.V. Freund MRC Laboratory of Molecular Biology
Gunnar von Heijne
Gunnar von Heijne Stockholm University
Benjamin Schuler
Benjamin Schuler University of Zurich
Valerie Daggett
Valerie Daggett University of Washington
Michele Vendruscolo
Michele Vendruscolo University of Cambridge
Roland Beckmann
Roland Beckmann Ludwig-Maximilians-Universität München
Cyrus Chothia
Cyrus Chothia MRC Laboratory of Molecular Biology
Sarah A. Teichmann
Sarah A. Teichmann University of Cambridge

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