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Chemistry

D-Index
67
Citations
18640
World Ranking
6814
National Ranking
2044

Biology and Biochemistry

D-Index
67
Citations
18808
World Ranking
8116
National Ranking
3673

Overview

John R. Engen is affiliated with Northeastern University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus also on Medicine. The subfields of their work include Molecular Biology, Spectroscopy, Oncology, Genetics, and Cell Biology.

The main topics that Engen has explored comprise Mass Spectrometry Techniques and Applications, Protein Structure and Dynamics, Analytical Chemistry and Chromatography, Ubiquitin and proteasome pathways, Enzyme Structure and Function, Chronic Lymphocytic Leukemia Research, and Chronic Myeloid Leukemia Treatments.

Among the frequent co-authors collaborating with Engen are Thomas E. Wales, Loren D. Walensky, Daniele Peterle, Roxana E. Iacob, and Amy H. Andreotti.

Engen's publications appear repeatedly in several scientific journals and preprint servers. Frequent venues include bioRxiv (Cold Spring Harbor Laboratory), eLife, Journal of Biological Chemistry, Nature Communications, and Journal of Molecular Biology.

Their recent papers include:

  • Developments in Hydrogen/Deuterium Exchange Mass Spectrometry, 2020, Analytical Chemistry
  • Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems, 2021, Chemical Reviews
  • Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism, 2020, Scientific Reports
  • Structural mechanism of a drug-binding process involving a large conformational change of the protein target, 2023, Nature Communications
  • Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase, 2021, Molecular Cell

Best Publications

  • Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

    Wenjun Zhou;Dalia Ercan;Liang Chen;Cai-Hong Yun

  • Hydrogen exchange mass spectrometry for the analysis of protein dynamics.

    Thomas E. Wales;John R. Engen

  • Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.

    Glenn R. Masson;John E. Burke;Natalie G. Ahn;Ganesh S. Anand

  • Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

    Jianming Zhang;Francisco J. Adrián;Wolfgang Jahnke;Sandra W. Cowan-Jacob

  • Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars

    Steven A. Berkowitz;John R. Engen;Jeffrey R. Mazzeo;Graham B. Jones

  • Post-translational Modifications Differentially Affect IgG1 Conformation and Receptor Binding

    Damian Houde;Damian Houde;Yucai Peng;Steven A. Berkowitz;John R. Engen

  • Analysis of protein conformation and dynamics by hydrogen/deuterium exchange MS.

    John R. Engen

  • High-speed and high-resolution UPLC separation at zero degrees Celsius.

    Thomas E. Wales;Keith E. Fadgen;Geoff C. Gerhardt;John R. Engen

  • The Utility of Hydrogen/Deuterium Exchange Mass Spectrometry in Biopharmaceutical Comparability Studies

    Damian Houde;Damian Houde;Steven A. Berkowitz;John R. Engen

  • Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor†

    Sang Min Lim;Kenneth D. Westover;Scott B. Ficarro;Rane A. Harrison

  • Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome

    Yuan Shi;Xiang Chen;Suzanne Elsasser;Bradley B. Stocks

  • Semi-automated data processing of hydrogen exchange mass spectra using HX-Express

    David D. Weis;John R. Engen;Ignatius J. Kass

  • Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

    Wenyu Yu;Emma J. Chory;Emma J. Chory;Amy K. Wernimont;Wolfram Tempel

  • Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding

    Edward C. Twomey;Zhejian Ji;Thomas E. Wales;Nicholas O. Bodnar

  • Force Interacts with Macromolecular Structure in Activation of TGF-β

    Xianchi Dong;Bo Zhao;Roxana E. Iacob;Jianghai Zhu

  • Investigating protein structure and dynamics by hydrogen exchange MS.

    John R. Engen;David L. Smith

  • Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems.

    Ellie I James;Taylor A Murphree;Clint Vorauer;John R Engen

  • Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice.

    Rida Mourtada;Rida Mourtada;Henry D. Herce;Daniel J. Yin;Jamie A. Moroco

  • Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry.

    Damian Houde;Joseph Arndt;Wayne Domeier;Steven Berkowitz

  • Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis.

    David D. Weis;Thomas E. Wales;John R. Engen;Matthew Hotchko

  • FOCUS :H YDROGEN EXCHANGE AND COVALENT MODIFICATION Identification and Characterization of EX1 Kinetics in H/D Exchange Mass Spectrometry by Peak Width Analysis

    David D. Weis;Thomas E. Wales;John R. Engen;Matthew Hotchko

Frequent Co-Authors

Thomas E. Smithgall
Thomas E. Smithgall University of Pittsburgh
Loren D. Walensky
Loren D. Walensky Harvard University
Timothy A. Springer
Timothy A. Springer Boston Children's Hospital
Nathanael S. Gray
Nathanael S. Gray Stanford University
Jarrod A. Marto
Jarrod A. Marto Harvard University
Scott B. Ficarro
Scott B. Ficarro Harvard University
Stephen C. Blacklow
Stephen C. Blacklow Harvard University
Alexandros Makriyannis
Alexandros Makriyannis Northeastern University
Sushil K. Satija
Sushil K. Satija National Institute of Standards and Technology
Kevin M. Haigis
Kevin M. Haigis Harvard University

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