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Chemistry

D-Index
52
Citations
8028
World Ranking
13686
National Ranking
3551

Overview

Igor A. Kaltashov is affiliated with the University of Massachusetts Amherst in the United States. Their research spans multiple disciplines primarily within medicine, biochemistry, genetics, molecular biology, and chemistry. The main focus of their work centers on mass spectrometry techniques and applications, platelet disorders and treatments, and the study of heparin-induced thrombocytopenia and thrombosis.

Their scientific contributions include studies in subfields such as spectroscopy, hematology, molecular biology, infectious diseases, and surgery. These areas reflect a broad engagement with both fundamental and applied aspects of biomedical research.

Their recent notable publications include:

  • The Utility of Native MS for Understanding the Mechanism of Action of Repurposed Therapeutics in COVID-19: Heparin as a Disruptor of the SARS-CoV-2 Interaction with Its Host Cell Receptor, 2020, Analytical Chemistry
  • Utilization of sonication-glycation to improve the functional properties of ovalbumin: A high-resolution mass spectrometry study, 2021, Food Hydrocolloids
  • Mass spectrometry-based methods in characterization of the higher order structure of protein therapeutics, 2020, Journal of Pharmaceutical and Biomedical Analysis
  • Charge Manipulation Using Solution and Gas-Phase Chemistry to Facilitate Analysis of Highly Heterogeneous Protein Complexes in Native Mass Spectrometry, 2021, Analytical Chemistry
  • Mass spectrometry-based methods to characterize highly heterogeneous biopharmaceuticals, vaccines, and nonbiological complex drugs at the intact-mass level, 2022, Mass Spectrometry Reviews

Key co-authors frequently collaborating with Igor A. Kaltashov include Daniil G. Ivanov, Yi Du, Ishac Nazy, Cedric E. Bobst, and Nikola Ivetic. These collaborations contribute to a body of work that integrates expertise across disciplines connected to protein analysis, therapeutic development, and clinical research.

Common publication venues associated with their work reflect a concentration in analytical chemistry and biomedical sciences, including:

  • Analytical Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Food Hydrocolloids
  • Journal of Pharmaceutical and Biomedical Analysis
  • Mass Spectrometry Reviews

Their research topics also encompass:

  • Mass Spectrometry Techniques and Applications
  • Platelet Disorders and Treatments
  • Heparin-Induced Thrombocytopenia and Thrombosis
  • Monoclonal and Polyclonal Antibodies Research
  • SARS-CoV-2 and COVID-19 Research
  • Proteoglycans and Glycosaminoglycans Research
  • Protein Purification and Stability

Best Publications

  • Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.

    Glenn R. Masson;John E. Burke;Natalie G. Ahn;Ganesh S. Anand

  • Estimates of protein surface areas in solution by electrospray ionization mass spectrometry.

    Igor A. Kaltashov;Anirban Mohimen

  • Studies of biomolecular conformations and conformational dynamics by mass spectrometry.

    Igor A. Kaltashov;Stephen J. Eyles

  • Detection of Multiple Protein Conformational Ensembles in Solution via Deconvolution of Charge-State Distributions in ESI MS

    Andras Dobo;Igor A. Kaltashov

  • Do ionic charges in ESI MS provide useful information on macromolecular structure

    Igor A. Kaltashov;Rinat R. Abzalimov

  • Advances and challenges in analytical characterization of biotechnology products: mass spectrometry-based approaches to study properties and behavior of protein therapeutics

    Igor A. Kaltashov;Cedric E. Bobst;Rinat R. Abzalimov;Guanbo Wang

  • Cancer metabolomic markers in urine: evidence, techniques and recommendations.

    Sarah S. Dinges;Annika Hohm;Lindsey A. Vandergrift;Johannes Nowak

  • H/D Exchange and Mass Spectrometry in the Studies of Protein Conformation and Dynamics: Is There a Need for a Top-Down Approach?

    Igor A. Kaltashov;Cedric E. Bobst;Rinat R. Abzalimov

  • Methods to study protein dynamics and folding by mass spectrometry

    Stephen J Eyles;Igor A Kaltashov

  • Protein Conformations Can Be Probed in Top-Down HDX MS Experiments Utilizing Electron Transfer Dissociation of Protein Ions Without Hydrogen Scrambling

    Rinat R. Abzalimov;Desmond A. Kaplan;Michael L. Easterling;Igor A. Kaltashov

  • Characterization of intrinsically disordered proteins with electrospray ionization mass spectrometry: conformational heterogeneity of alpha-synuclein.

    Agya K. Frimpong;Rinat R. Abzalimov;Vladimir N. Uversky;Vladimir N. Uversky;Igor A. Kaltashov

  • Mass spectrometry in biophysics : conformation and dynamics of biomolecules

    Igor A. Kaltashov;Stephen J. Eyles

  • Highly asymmetric interactions between globin chains during hemoglobin assembly revealed by electrospray ionization mass spectrometry.

    Wendell P. Griffith;Igor A. Kaltashov

  • Characterization of Intact Protein Conjugates and Biopharmaceuticals Using Ion-Exchange Chromatography with Online Detection by Native Electrospray Ionization Mass Spectrometry and Top-Down Tandem Mass Spectrometry

    Khaja Muneeruddin;Mark Nazzaro;Igor A. Kaltashov

  • Mass spectrometry‐based methods to study protein architecture and dynamics

    Igor A. Kaltashov;Cedric E. Bobst;Rinat R. Abzalimov

  • A chemometric approach to detection and characterization of multiple protein conformers in solution using electrospray ionization mass spectrometry

    Anirban Mohimen;Andras Dobo;Joshua K. Hoerner;Igor A. Kaltashov

  • Electrospray ionization mass spectrometry of highly heterogeneous protein systems: protein ion charge state assignment via incomplete charge reduction.

    Rinat R. Abzalimov;Igor A. Kaltashov

  • Is There Hydrogen Scrambling in the Gas Phase? Energetic and Structural Determinants of Proton Mobility within Protein Ions

    Joshua K. Hoerner;Hui Xiao;and Andras Dobo;Igor A. Kaltashov

  • Mapping protein energy landscapes with amide hydrogen exchange and mass spectrometry: I. A generalized model for a two-state protein and comparison with experiment.

    Hui Xiao;Joshua K Hoerner;Stephen J Eyles;Andras Dobo

  • Protein conformational stability probed by Fourier transform ion cyclotron resonance mass spectrometry

    Stephen J. Eyles;J. Paul Speir;Gary H. Kruppa;and Lila M. Gierasch

Frequent Co-Authors

Robert J. Cotter
Robert J. Cotter Johns Hopkins University School of Medicine
Catherine Fenselau
Catherine Fenselau University of Maryland, College Park
Zong-cai Tu
Zong-cai Tu Nanchang University
Paul L. Dubin
Paul L. Dubin University of Massachusetts Amherst
Vladimir N. Uversky
Vladimir N. Uversky University of South Florida
Christian R. H. Raetz
Christian R. H. Raetz Duke University
Qing-Yu He
Qing-Yu He Jinan University
John R. Engen
John R. Engen Northeastern University
Lila M. Gierasch
Lila M. Gierasch University of Massachusetts Amherst
Duncan J. Maskell
Duncan J. Maskell University of Melbourne

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