World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
55
Citations
10770
World Ranking
12133
National Ranking
686

Biology and Biochemistry

D-Index
57
Citations
11651
World Ranking
13838
National Ranking
1084

Overview

Frank Sobott is affiliated with the University of Leeds in the United Kingdom. Their research spans a wide array of topics primarily within the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus also on Medicine.

The scientist's work addresses several subfields:

  • Molecular Biology
  • Spectroscopy
  • Neurology
  • Physiology
  • Cell Biology

Key topics covered in their research include:

  • Mass Spectrometry Techniques and Applications
  • Parkinson's Disease Mechanisms and Treatments
  • Alzheimer's Disease Research and Treatments
  • Advanced Electron Microscopy Techniques and Applications
  • Lipid Membrane Structure and Behavior
  • Electron and X-Ray Spectroscopy Techniques
  • Protein Structure and Dynamics

Their publication record highlights several recent papers:

  • "Author Correction: Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis," 2022, Communications Biology
  • "Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity," 2020, Nature Communications
  • "Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry," 2020, Journal of the American Society for Mass Spectrometry
  • "Do Aptamers Always Bind? The Need for a Multifaceted Analytical Approach When Demonstrating Binding Affinity between Aptamer and Low Molecular Weight Compounds," 2020, Journal of the American Chemical Society
  • "Metal ions shape α-synuclein," 2020, Scientific Reports

The most frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Structure
  • Journal of the American Society for Mass Spectrometry
  • Journal of the American Chemical Society

Frank Sobott has collaborated regularly with several researchers. Frequent co-authors are:

  • Stephen P. Muench
  • David P. Klebl
  • Sheena E. Radford
  • Rani Moons
  • Albert Konijnenberg

In addition to journal articles, the scientist has contributed to book publications. One known title is Ion Mobility-Mass Spectrometry, published by the Royal Society of Chemistry in 2021.

Best Publications

  • A tandem mass spectrometer for improved transmission and analysis of large macromolecular assemblies.

    Frank Sobott;Helena Hernandez;Margaret G. Mccammon;Mark A. Tito

  • Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics

    Steven Boeynaems;Elke Bogaert;Denes Kovacs;Albert Konijnenberg

  • Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family.

    X Yang;W H Lee;F Sobott;E Papagrigoriou

  • Recommendations for reporting ion mobility Mass Spectrometry measurements

    Valérie Gabelica;Alexandre A. Shvartsburg;Carlos Afonso;Perdita Barran

  • A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover.

    Egon Deyaert;Lina Wauters;Lina Wauters;Giambattista Guaitoli;Albert Konijnenberg

  • Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study

    Nicola A. Burgess-Brown;Sujata Sharma;Frank Sobott;Christoph Loenarz

  • Structure of an Hsp90-Cdc37-Cdk4 Complex

    Cara K. Vaughan;Ulrich Gohlke;Frank Sobott;Valerie M. Good

  • Native ion mobility-mass spectrometry and related methods in structural biology.

    A. Konijnenberg;A. Butterer;F. Sobott

  • Tandem mass spectrometry reveals the quaternary organization of macromolecular assemblies.

    Justin L.P. Benesch;J. Andrew Aquilina;Brandon T. Ruotolo;Frank Sobott

  • Subunit exchange of multimeric protein complexes. Real-time monitoring of subunit exchange between small heat shock proteins by using electrospray mass spectrometry.

    Frank Sobott;Justin L.P. Benesch;Elizabeth Vierling;Carol V. Robinson

  • The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins.

    Stephen H. McLaughlin;Frank Sobott;Zhong-ping Yao;Wei Zhang

  • Protomers of Benzocaine: Solvent and Permittivity Dependence

    Stephan Warnke;Jongcheol Seo;Jasper Boschmans;Frank Sobott

  • Thermal dissociation of multimeric protein complexes by using nanoelectrospray mass spectrometry.

    Justin L. P. Benesch;Frank Sobott;Carol V. Robinson

  • Protein complexes gain momentum.

    Frank Sobott;Carol V Robinson

  • Heptameric (L12)6/L10 rather than canonical pentameric complexes are found by tandem MS of intact ribosomes from thermophilic bacteria.

    Leopold L. Ilag;Hortense Videler;Adam R. McKay;Frank Sobott

  • Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity

    Amberley D. Stephens;Maria Zacharopoulou;Rani Moons;Giuliana Fusco

  • Characterising electrosprayed biomolecules using tandem-MS—the noncovalent GroEL chaperonin assembly

    Frank Sobott;Carol V. Robinson

  • First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study.

    Claudio Iacobucci;Christine Piotrowski;Ruedi Aebersold;Ruedi Aebersold;Bruno C. Amaral

  • Structural and Functional Characterization of the Human Protein Kinase ASK1

    Gabor Bunkoczi;Eidarus Salah;Panagis Filippakopoulos;Oleg Fedorov

  • Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia

    Esther B E Becker;Luigi Zuliani;Rosemary Pettingill;Bethan Lang

Frequent Co-Authors

Carol V. Robinson
Carol V. Robinson University of Oxford
Remy Loris
Remy Loris Vrije Universiteit Brussel
Bernhard Brutschy
Bernhard Brutschy Goethe University Frankfurt
Juri Rappsilber
Juri Rappsilber Technical University of Berlin
Justin L. P. Benesch
Justin L. P. Benesch University of Oxford
Mark S. Dillingham
Mark S. Dillingham University of Bristol
Geert Baggerman
Geert Baggerman University of Antwerp
Christoph H. Borchers
Christoph H. Borchers McGill University

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