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Anastassios Economou

Anastassios Economou

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
8984
World Ranking
18005
National Ranking
298

Overview

Anastassios Economou is a researcher affiliated with KU Leuven in Belgium, specializing in the field of Biochemistry, Genetics, and Molecular Biology. Their work predominantly focuses on molecular biology, with substantial contributions to subfields such as genetics, spectroscopy, cellular and molecular neuroscience, and materials chemistry.

The scientist has contributed extensively to topics including protein structure and dynamics, bacterial genetics and biotechnology, RNA and protein synthesis mechanisms, advanced proteomics techniques and applications, mass spectrometry techniques and applications, photochromic and fluorescence chemistry, as well as photoreceptor and optogenetics research.

Recent notable papers authored or co-authored by Economou include:

  • Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis, 2021, Cell Death and Differentiation
  • Trigger factor is a bona fide secretory pathway chaperone that interacts with SecB and the translocase, 2020, EMBO Reports
  • EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation, 2023, Neuron
  • Probing Universal Protein Dynamics Using Hydrogen-Deuterium Exchange Mass Spectrometry-Derived Residue-Level Gibbs Free Energy, 2021, Analytical Chemistry
  • The structural basis for an on-off switch controlling Gβγ-mediated inhibition of TRPM3 channels, 2020, Proceedings of the National Academy of Sciences

Frequent collaborators in Economou's research include Spyridoula Karamanou, Jochem H. Smit, Srinath Krishnamurthy, Athina G. Portaliou, and Bindu Y. Srinivasu.

The researcher has published regularly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, Journal of Molecular Biology, Analytical Chemistry, and Alzheimer's & Dementia.

Economou has also contributed to academic books, notably publishing with Frontiers Media on the subject of protein trafficking and transport, with a recent title "Targeting Signals in Protein Trafficking and Transport" released in 2023.

Best Publications

  • SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion

    Anastassios Economou;William Wickner

  • Structural Basis for Signal-Sequence Recognition by the Translocase Motor SecA as Determined by NMR

    Ioannis Gelis;Alexandre M.J.J. Bonvin;Dimitra Keramisanou;Marina Koukaki

  • Protein export through the bacterial Sec pathway

    Alexandra Tsirigotaki;Jozefien De Geyter;Nikolina Šoštaric;Anastassios Economou

  • SecA membrane cycling at SecYEG is driven by distinct ATP binding and hydrolysis events and is regulated by SecD and SecF

    Anastassios Economou;Joseph A. Pogliano;Jonathan Beckwith;Donald B. Oliver

  • Bacterial protein secretion through the translocase nanomachine

    Effrosyni Papanikou;Spyridoula Karamanou;Anastassios Economou;Anastassios Economou

  • Structural basis for protein antiaggregation activity of the trigger factor chaperone.

    Tomohide Saio;Xiao Guan;Paolo Rossi;Anastassios Economou;Anastassios Economou

  • The Rhizobium nodulation gene nodO encodes a Ca2(+)-binding protein that is exported without N-terminal cleavage and is homologous to haemolysin and related proteins.

    Anastassios Economou;W D Hamilton;A W Johnston;J A Downie

  • Type III Secretion: Building and Operating a Remarkable Nanomachine

    Athina G. Portaliou;Athina G. Portaliou;Konstantinos C. Tsolis;Konstantinos C. Tsolis;Maria S. Loos;Maria S. Loos;Valentina Zorzini

  • Structure of dimeric SecA, the Escherichia coli preprotein translocase motor.

    Yannis Papanikolau;Maria Papadovasilaki;Raimond B.G. Ravelli;Andrew A. McCarthy

  • Structure and function of SecA, the preprotein translocase nanomotor.

    Eleftheria Vrontou;Anastassios Economou

  • Signal peptides are allosteric activators of the protein translocase.

    Giorgos Gouridis;Spyridoula Karamanou;Ioannis Gelis;Charalampos G. Kalodimos

  • A molecular switch in SecA protein couples ATP hydrolysis to protein translocation.

    Spyridoula Karamanou;Eleftheria Vrontou;George Sianidis;Catherine Baud

  • SecYEG and SecA Are the Stoichiometric Components of Preprotein Translocase

    Karen Douville;Albert Price;Jerry Eichler;Anastassios Economou;Anastassios Economou

  • Cross-talk between catalytic and regulatory elements in a DEAD motor domain is essential for SecA function

    Georgios Sianidis;Spyridoula Karamanou;Eleftheria Vrontou;Kostantinos Boulias

  • Identification of the Preprotein Binding Domain of SecA

    Efrosyni Papanikou;Spyridoula Karamanou;Catherine Baud;Miriam Frank

  • BACTERIAL PREPROTEIN TRANSLOCASE : MECHANISM AND CONFORMATIONAL DYNAMICS OF A PROCESSIVE ENZYME

    Anastassios Economou

  • The Escherichia coli Peripheral Inner Membrane Proteome

    Malvina Papanastasiou;Georgia Orfanoudaki;Marina Koukaki;Nikos Kountourakis

  • SecA-mediated targeting and translocation of secretory proteins

    Katerina E. Chatzi;Marios Frantzeskos Sardis;Anastassios Economou;Anastassios Economou;Spyridoula Karamanou;Spyridoula Karamanou

  • Complete genome sequence of Streptomyces lividans TK24.

    Christian Rückert;Andreas Albersmeier;Tobias Busche;Sebastian Jaenicke

  • Disorder-order folding transitions underlie catalysis in the helicase motor of SecA

    Dimitra Keramisanou;Nikolaos Biris;Ioannis Gelis;Georgios Sianidis

Frequent Co-Authors

Jozef Anné
Jozef Anné KU Leuven
Jörn Kalinowski
Jörn Kalinowski Bielefeld University
Andreas Kuhn
Andreas Kuhn University of Hohenheim
Wolfgang Wiechert
Wolfgang Wiechert Forschungszentrum Jülich
Nickolas J. Panopoulos
Nickolas J. Panopoulos University of Crete
Anthony P. Pugsley
Anthony P. Pugsley Institut Pasteur
Theodore Fotsis
Theodore Fotsis Foundation for Research and Technology Hellas

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