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Microbiology

D-Index
57
Citations
14693
World Ranking
3539
National Ranking
1396

Overview

Michael B. Zwick is affiliated with the Scripps Research Institute in the United States. Their research primarily focuses on immunology and microbiology, with significant contributions to the fields of medicine and biochemistry, genetics, and molecular biology. Their work spans several interconnected subfields, including virology, molecular biology, immunology, epidemiology, and infectious diseases.

The scientist's research topics cover a range of areas related to HIV and immune responses, specifically:

  • HIV research and treatment
  • Lipid membrane structure and behavior
  • Cytomegalovirus and herpesvirus research
  • Monoclonal and polyclonal antibodies research
  • Immunotherapy and immune responses
  • HIV/AIDS drug development and treatment
  • RNA interference and gene delivery

Michael B. Zwick has contributed to multiple recent publications, including:

  • HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies, 2020, Cell Reports
  • Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice, 2022, Cell
  • HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes, 2023, Nature
  • A V H 1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite, 2020, Science Advances
  • Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments, 2020, Cell Reports

Their publications appear frequently in several venues, highlighting a consistent focus on biomedical research:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • Nature
  • Cell
  • Science Advances

Collaboration is a notable aspect of their research, with frequent co-authors including:

  • Daniel P. Leaman
  • Lei Zhang
  • Edurne Rujas
  • Sara Insausti
  • José M. M. Caaveiro

Best Publications

  • Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design.

    Erica Ollmann Saphire;Paul W. H. I. Parren;Ralph Pantophlet;Michael B. Zwick

  • Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.

    Michael B. Zwick;Aran F. Labrijn;Meng Wang;Catherine Spenlehauer

  • Antibody Domain Exchange Is an Immunological Solution to Carbohydrate Cluster Recognition

    Daniel A. Calarese;Christopher N. Scanlan;Michael B. Zwick;Songpon Deechongkit

  • Structural definition of a conserved neutralization epitope on HIV-1 gp120.

    Tongqing Zhou;Ling Xu;Barna Dey;Ann J. Hessell

  • Comprehensive Cross-Clade Neutralization Analysis of a Panel of Anti-Human Immunodeficiency Virus Type 1 Monoclonal Antibodies

    James M. Binley;Terri Wrin;Bette Korber;Michael B. Zwick

  • Broadly Neutralizing Anti-HIV Antibody 4E10 Recognizes a Helical Conformation of a Highly Conserved Fusion-Associated Motif in gp41

    Rosa M.F. Cardoso;Michael B. Zwick;Robyn L. Stanfield;Renate Kunert

  • A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals.

    Laura M. Walker;Melissa D. Simek;Frances Priddy;Johannes S. Gach

  • Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers

    Emilia Falkowska;Khoa M. Le;Khoa M. Le;Alejandra Ramos;Alejandra Ramos;Katie J. Doores;Katie J. Doores;Katie J. Doores

  • Access of Antibody Molecules to the Conserved Coreceptor Binding Site on Glycoprotein gp120 Is Sterically Restricted on Primary Human Immunodeficiency Virus Type 1

    Aran F. Labrijn;Pascal Poignard;Aarti Raja;Michael B. Zwick

  • Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1.

    Penny L. Moore;Emma T. Crooks;Lauren Porter;Ping Zhu

  • Anti-Human Immunodeficiency Virus Type 1 (HIV-1) Antibodies 2F5 and 4E10 Require Surprisingly Few Crucial Residues in the Membrane-Proximal External Region of Glycoprotein gp41 To Neutralize HIV-1

    Michael B. Zwick;Richard Jensen;Sarah Church;Meng Wang

  • Salmonella induces the formation of filamentous structures containing lysosomal membrane glycoproteins in epithelial cells

    F. Garcia-Del Portillo;M. B. Zwick;Ka Yin Leung;B. B. Finlay

  • Identification of a Salmonella virulence gene required for formation of filamentous structures containing lysosomal membrane glycoproteins within epithelial cells

    Murry A. Stein;Ka Yin Leung;Michael Zwick;Francisco Garcia-del Portillo

  • Tyrosine Sulfation of Human Antibodies Contributes to Recognition of the CCR5 Binding Region of HIV-1 gp120

    Hyeryun Choe;Wenhui Li;Paulette L. Wright;Natalya Vasilieva

  • An Affinity-Enhanced Neutralizing Antibody against the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 gp41 Recognizes an Epitope between Those of 2F5 and 4E10

    Josh D. Nelson;Florence M. Brunel;Richard Jensen;Emma T. Crooks

  • The Long Third Complementarity-Determining Region of the Heavy Chain Is Important in the Activity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5

    Michael B. Zwick;H. Kiyomi Komori;Robyn L. Stanfield;Sarah Church

  • Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.

    Rosa M.F. Cardoso;Florence M. Brunel;Sharon Ferguson;Michael Zwick

  • Structure-Function Analysis of the Epitope for 4E10, a Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody

    Florence M. Brunel;Michael B. Zwick;Rosa M. F. Cardoso;Josh D. Nelson

  • Neutralization Synergy of Human Immunodeficiency Virus Type 1 Primary Isolates by Cocktails of Broadly Neutralizing Antibodies

    Michael B. Zwick;Meng Wang;Pascal Poignard;Gabriela Stiegler

  • Molecular Features of the Broadly Neutralizing Immunoglobulin G1 b12 Required for Recognition of Human Immunodeficiency Virus Type 1 gp120

    Michael B. Zwick;Paul W. H. I. Parren;Erica O. Saphire;Sarah Church

Frequent Co-Authors

Dennis R. Burton
Dennis R. Burton Scripps Research Institute
Ian A. Wilson
Ian A. Wilson Scripps Research Institute
Richard T. Wyatt
Richard T. Wyatt Scripps Research Institute
Peter D. Kwong
Peter D. Kwong Columbia University Medical Center
Dimiter S. Dimitrov
Dimiter S. Dimitrov University of Pittsburgh
Andrew B. Ward
Andrew B. Ward Scripps Research Institute
Paul W. H. I. Parren
Paul W. H. I. Parren Leiden University Medical Center
Joseph Sodroski
Joseph Sodroski Harvard Medical School
Gary J. Nabel
Gary J. Nabel ModeX Therapeutics
Tongqing Zhou
Tongqing Zhou National Institutes of Health

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