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Biology and Biochemistry

D-Index
58
Citations
11012
World Ranking
13280
National Ranking
928

Overview

Takashi Kojima is affiliated with Sapporo Medical University in Japan, where their research primarily focuses on molecular biology, medicine, and neuroscience. Their work intersects several subfields, including molecular biology, neurology, cancer research, pulmonary and respiratory medicine, and surgery.

Their research encompasses a range of topics such as barrier structure and function studies, cancer-related molecular mechanisms research, ferroptosis and cancer prognosis, advanced glycation end products research, Hippo pathway signaling and YAP/TAZ, connexins and lens biology, and esophageal cancer research and treatment.

Several recent papers illustrate the scope of Kojima's research interests and contributions. These include:

  • Role of tight junctions in the epithelial-to-mesenchymal transition of cancer cells, 2020, Biochimica et Biophysica Acta (BBA) - Biomembranes
  • HDAC inhibitors suppress the proliferation, migration and invasiveness of human head and neck squamous cell carcinoma cells via p63-mediated tight junction molecules and p21-mediated growth arrest, 2021, Oncology Reports
  • The Roles of Tricellular Tight Junction Protein Angulin-1/Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Endometriosis and Endometrioid-Endometrial Carcinoma, 2021, Cancers
  • Serial change of neutrophil extracellular traps in tracheal aspirate of patients with acute respiratory distress syndrome: report of three cases, 2020, Journal of Intensive Care
  • HMGB1-downregulated angulin-1/LSR induces epithelial barrier disruption via claudin-2 and cellular metabolism via AMPK in airway epithelial Calu-3 cells, 2020, Biochemical and Biophysical Research Communications

Kojima frequently publishes in venues including Tissue Barriers, Cancers, Histochemistry and Cell Biology, International Journal of Molecular Sciences, and Cellular and Molecular Neurobiology.

Co-authorship is a significant aspect of Kojima's work, collaborating extensively with colleagues such as Takayuki Kohno, Takumi Konno, Shin Kikuchi, Kenichi Takano, and Yuma Shindo. These collaborations reflect a network of research efforts in related scientific domains.

Best Publications

  • Transmembrane proteins of tight junctions.

    Hideki Chiba;Makoto Osanai;Masaki Murata;Takashi Kojima

  • Tight junctions and human diseases.

    Norimasa Sawada;Masaki Murata;Keisuke Kikuchi;Makoto Osanai

  • Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes.

    Hiroki Fujita;Kotaro Sugimoto;Shuichiro Inatomi;Toshihiro Maeda

  • Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells

    Kunihiko Nagasawa;Hideki Chiba;Hiroki Fujita;Takashi Kojima

  • Differential Expression and Subcellular Localization of Claudin-7, −8, −12, −13, and −15 Along the Mouse Intestine

    Hiroki Fujita;Hideki Chiba;Hiroshi Yokozaki;Naoyuki Sakai

  • Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood–brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways

    Tsutomu Ishizaki;Hideki Chiba;Takashi Kojima;Masato Fujibe

  • The p53 family member genes are involved in the Notch signal pathway.

    Yasushi Sasaki;Setsuko Ishida;Ichiro Morimoto;Toshiharu Yamashita

  • Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer.

    Ayumi Satoh;Minoru Toyota;Fumio Itoh;Yasushi Sasaki

  • Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells.

    Tamaki Okabayashi;Takashi Kojima;Tomoyuki Masaki;Shin-ichi Yokota

  • HLA-DR- and CD11c-positive dendritic cells penetrate beyond well-developed epithelial tight junctions in human nasal mucosa of allergic rhinitis.

    Ken-ichi Takano;Takashi Kojima;Mitsuru Go;Masaki Murata

  • Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions.

    Masato Fujibe;Hideki Chiba;Takashi Kojima;Tamotsu Soma

  • The role of IL‐33 and its receptor ST2 in human nasal epithelium with allergic rhinitis

    R. Kamekura;T. Kojima;K. Takano;M. Go

  • Thr207 of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP

    Tamotsu Soma;Hideki Chiba;Yuko Kato-Mori;Takuro Wada

  • Regulation of Tight Junctions in Upper Airway Epithelium

    Takashi Kojima;Mitsuru Go;Ken-ichi Takano;Makoto Kurose

  • Epigenetic Silencing of Occludin Promotes Tumorigenic and Metastatic Properties of Cancer Cells via Modulations of Unique Sets of Apoptosis-Associated Genes

    Makoto Osanai;Masaki Murata;Nami Nishikiori;Hideki Chiba

  • Cx32 but not Cx26 is associated with tight junctions in primary cultures of rat hepatocytes.

    Takashi Kojima;Yasuo Kokai;Hideki Chiba;Masao Yamamoto

  • Regulation of the blood-biliary barrier: interaction between gap and tight junctions in hepatocytes.

    Takashi Kojima;Toshinobu Yamamoto;Masaki Murata;Hideki Chiba

  • Cellular retinoic acid bioavailability determines epithelial integrity: Role of retinoic acid receptor alpha agonists in colitis.

    Makoto Osanai;Nami Nishikiori;Masaki Murata;Hideki Chiba

  • Growth and Maturation of Small Hepatocytes Isolated from Adult Rat Liver

    T. Mitaka;T. Kojima;T. Mizuguchi;Y. Mochizuki

  • Hepatocyte nuclear factor (HNF)-4α triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells

    Hideki Chiba;Tomoko Gotoh;Takashi Kojima;Seiro Satohisa

Frequent Co-Authors

Norimasa Sawada
Norimasa Sawada Sapporo Medical University
Hideki Chiba
Hideki Chiba Fukushima Medical University
Koichi Hirata
Koichi Hirata Sapporo Medical University
David C. Spray
David C. Spray Albert Einstein College of Medicine
Nobuhiro Fujii
Nobuhiro Fujii Sapporo Medical University
Noriyuki Sato
Noriyuki Sato Sapporo Medical University
Takashi Tokino
Takashi Tokino Sapporo Medical University
Yoshio Kuroki
Yoshio Kuroki Sapporo Medical University
Kohzoh Imai
Kohzoh Imai University of Tokyo
Hiroshi Yokozaki
Hiroshi Yokozaki Kobe University

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