D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 64 Citations 27,588 155 World Ranking 1955 National Ranking 99

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cancer
  • DNA

Takashi Tokino focuses on Cancer research, Molecular biology, DNA methylation, Epigenetics and Gene. His research in Cancer research intersects with topics in Carcinogenesis, Cancer, Tumor suppressor gene, Wnt signaling pathway and Gene product. His study in Molecular biology is interdisciplinary in nature, drawing from both P53 binding, Promoter, Gene expression, Cell growth and Mitochondrion.

His Gene expression study incorporates themes from Regulation of gene expression, Angiogenesis and Cellular differentiation. The various areas that Takashi Tokino examines in his Gene study include Immunohistochemistry, Disease and DNA. His Reporter gene research incorporates themes from CDKN1A Gene, Gene interaction and Suppression subtractive hybridization.

His most cited work include:

  • WAF1, a potential mediator of p53 tumor suppression (7441 citations)
  • Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis (1733 citations)
  • p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53 (1054 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Cancer research, Molecular biology, Gene, Cancer and Genetics. His Cancer research research integrates issues from DNA methylation, Cancer cell, Apoptosis and Carcinogenesis, Tumor suppressor gene. His DNA methylation research is multidisciplinary, incorporating perspectives in Regulation of gene expression, Gene silencing, Methylation and Epigenetics.

His Tumor suppressor gene research is multidisciplinary, relying on both Gene product and Transcription factor. His Molecular biology research includes elements of Gene expression, DNA damage, Chromatin immunoprecipitation, Complementary DNA and Cell biology. Takashi Tokino interconnects Gene knockdown, Oncology and Bioinformatics in the investigation of issues within Cancer.

He most often published in these fields:

  • Cancer research (47.16%)
  • Molecular biology (26.42%)
  • Gene (25.42%)

What were the highlights of his more recent work (between 2014-2021)?

  • Cancer research (47.16%)
  • Cancer (23.41%)
  • Gene (25.42%)

In recent papers he was focusing on the following fields of study:

Cancer research, Cancer, Gene, Internal medicine and Oncology are his primary areas of study. His research integrates issues of Exome sequencing, Cell growth, DNA methylation, Gene knockdown and Cancer cell in his study of Cancer research. His DNA methylation research includes themes of Carcinogenesis, Methylation and Epigenetics.

He has researched Cancer in several fields, including Mutation, Molecular biology and Cisplatin. His Molecular biology study frequently links to related topics such as DNA. Gene is closely attributed to Cell biology in his work.

Between 2014 and 2021, his most popular works were:

  • Long non-coding RNA NEAT1 is a transcriptional target of p53 and modulates p53-induced transactivation and tumor-suppressor function. (49 citations)
  • Assessment of the quality of DNA from various formalin-fixed paraffin-embedded (FFPE) tissues and the use of this DNA for next-generation sequencing (NGS) with no artifactual mutation. (42 citations)
  • Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing (27 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Cancer
  • DNA

Takashi Tokino spends much of his time researching Cancer research, Cancer, microRNA, Germline mutation and Cell growth. The concepts of his Cancer research study are interwoven with issues in Exome sequencing, Gene knockdown, Cancer cell, Downregulation and upregulation and Chromatin. His research on Gene knockdown often connects related topics like Molecular biology.

His Molecular biology research incorporates elements of Antigen retrieval and DNA extraction. In his study, Carcinoma, RNA interference, CD44 and Cell culture is inextricably linked to Microarray analysis techniques, which falls within the broad field of Cell growth. His study looks at the relationship between Histone and topics such as DNA demethylation, which overlap with Regulation of gene expression.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

WAF1, a potential mediator of p53 tumor suppression

Wafik S. El-Deiry;Takashi Tokino;Victor E. Velculescu;Daniel B. Levy.
Cell (1993)

10578 Citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

Eri Oda;Rieko Ohki;Hideki Murasawa;Jiro Nemoto.
Science (2000)

2639 Citations

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage

Kay F. Macleod;Nicole Sherry;Greg Hannon;David Beach.
Genes & Development (1995)

1521 Citations

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

Katsutoshi Oda;Hirofumi Arakawa;Tomoaki Tanaka;Koichi Matsuda.
Cell (2000)

1385 Citations

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

Hiromu Suzuki;Hiromu Suzuki;D. Neil Watkins;Kam Wing Jair;Kornel E. Schuebel.
Nature Genetics (2004)

1173 Citations

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

Seiji Satoh;Yataro Daigo;Yoichi Furukawa;Tatsushi Kato.
Nature Genetics (2000)

1137 Citations

Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors.

David Sidransky;Takashi Tokino;Stanley R. Hamilton;Kenneth W. Kinzler.
Science (1992)

975 Citations

Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.

Minoru Toyota;Hiromu Suzuki;Yasushi Sasaki;Reo Maruyama.
Cancer Research (2008)

817 Citations

Topological Control of p21WAF1/CIP1 Expression in Normal and Neoplastic Tissues

Wafik S. El-Deiry;Wafik S. El-Deiry;Takashi Tokino;Todd Waldman;Jon D. Oliner.
Cancer Research (1995)

785 Citations

p53 Mutation and MDM2 Amplification in Human Soft Tissue Sarcomas

Fredrick S. Leach;Takashi Tokino;Takashi Tokino;Paul Meltzer;Marilee Burrell.
Cancer Research (1993)

703 Citations

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National Institutes of Health

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