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Genetics and Molecular Biology
Japan
2024

D-Index & Metrics

Genetics

D-Index
84
Citations
41694
World Ranking
1339
National Ranking
50

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Japan Leader Award

Overview

Takashi Tokino is affiliated with Sapporo Medical University in Japan and has contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research spans multiple subfields, including molecular biology, cancer research, oncology, pathology and forensic medicine, as well as pulmonary and respiratory medicine.

The main topics of Tokino's work encompass:

  • Cancer Genomics and Diagnostics
  • Genetic factors in colorectal cancer
  • Pancreatic and Hepatic Oncology Research
  • Cancer-related molecular mechanisms research
  • RNA modifications and cancer
  • Lung Cancer Treatments and Mutations
  • Gastric Cancer Management and Outcomes

Among their recent notable publications are:

  • "Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma," 2022, Hepatology
  • "Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo," 2021, Nature Communications
  • "Interactive Web-based Graphs of Coronavirus Disease 2019 Cases and Deaths per Population by Country," 2020, Clinical Infectious Diseases
  • "Frequent Tumor Burden Monitoring of Esophageal Squamous Cell Carcinoma With Circulating Tumor DNA Using Individually Designed Digital Polymerase Chain Reaction," 2020, Gastroenterology
  • "Individualized circulating tumor DNA monitoring in head and neck squamous cell carcinoma," 2022, Cancer Medicine

Tokino collaborates frequently with several researchers, including:

  • Masashi Idogawa
  • Yasushi Sasaki
  • Shoichiro Tange
  • Tokimasa Hida
  • Hisashi Uhara

Their research has been published predominantly in venues such as:

  • The Journal of Dermatology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Medicine
  • PLoS ONE
  • European Journal of Dermatology

Takashi Tokino's scholarly output reflects a broad and interdisciplinary approach to medical and molecular biological research, with a particular emphasis on cancer diagnostics and the molecular mechanisms underpinning various cancers. Their work involves both clinical and experimental settings, often focusing on innovative diagnostic modalities and the molecular characterization of cancerous tissues.

Best Publications

  • WAF1, a potential mediator of p53 tumor suppression

    Wafik S. El-Deiry;Takashi Tokino;Victor E. Velculescu;Daniel B. Levy

  • Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

    Eri Oda;Rieko Ohki;Hideki Murasawa;Jiro Nemoto

  • p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

    Katsutoshi Oda;Hirofumi Arakawa;Tomoaki Tanaka;Koichi Matsuda

  • p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage

    Kay F. Macleod;Nicole Sherry;Greg Hannon;David Beach

  • Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

    Hiromu Suzuki;Hiromu Suzuki;D. Neil Watkins;Kam Wing Jair;Kornel E. Schuebel

  • AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

    Seiji Satoh;Yataro Daigo;Yoichi Furukawa;Tatsushi Kato

  • Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors.

    David Sidransky;Takashi Tokino;Stanley R. Hamilton;Kenneth W. Kinzler

  • Topological Control of p21WAF1/CIP1 Expression in Normal and Neoplastic Tissues

    Wafik S. El-Deiry;Wafik S. El-Deiry;Takashi Tokino;Todd Waldman;Jon D. Oliner

  • Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.

    Minoru Toyota;Hiromu Suzuki;Yasushi Sasaki;Reo Maruyama

  • p53 Mutation and MDM2 Amplification in Human Soft Tissue Sarcomas

    Fredrick S. Leach;Takashi Tokino;Takashi Tokino;Paul Meltzer;Marilee Burrell

  • Sequence-specific transcriptional activation is essential for growth suppression by p53.

    Jennifer A. Pietenpol;Takashi Tokino;Sam Thiagalingam;Wafik S. El-Deiry

  • Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line

    Katsunori Nakano;Takakazu Mizuno;Yoshihiro Sowa;Tetsuro Orita

  • Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage

    Nobuyuki Tanaka;Masahiko Ishihara;Marc S. Lamphier;Hiroaki Nozawa

  • Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors

    Takeshi Niinuma;Hiromu Suzuki;Masanori Nojima;Katsuhiko Nosho

  • A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis

    Hiroyuki Nishimori;Takayuki Shiratsuchi;Takayuki Shiratsuchi;Tsutomu Urano;Yasutoshi Kimura

  • Allelotype study of primary hepatocellular carcinoma.

    M Fujimori;T Tokino;O Hino;T Kitagawa

  • Inherited p53 gene mutations in breast cancer.

    D Sidransky;T Tokino;K Helzlsouer;B Zehnbauer

  • Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer

    H Suzuki;M Toyota;M Toyota;H Caraway;E Gabrielson

  • Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.

    M Nojima;H Suzuki;M Toyota;M Toyota;Y Watanabe

  • Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.

    Hironobu Sato;Hiromu Suzuki;Minoru Toyota;Masanori Nojima

Frequent Co-Authors

Hiromu Suzuki
Hiromu Suzuki Sapporo Medical University
Minoru Toyota
Minoru Toyota Sapporo Medical University
Kohzoh Imai
Kohzoh Imai University of Tokyo
Yasuhisa Shinomura
Yasuhisa Shinomura Sapporo Medical University
Yusuke Nakamura
Yusuke Nakamura National Institutes of Biomedical Innovation, Health and Nutrition
Koichi Hirata
Koichi Hirata Sapporo Medical University
Hiroyuki Yamamoto
Hiroyuki Yamamoto St. Marianna University School of Medicine
Kenichi Matsubara
Kenichi Matsubara Osaka University
Noriyuki Sato
Noriyuki Sato Sapporo Medical University
Bert Vogelstein
Bert Vogelstein Johns Hopkins University

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