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Peter V. Kharchenko

Peter V. Kharchenko

D-Index & Metrics

Genetics

D-Index
78
Citations
35850
World Ranking
1669
National Ranking
767

Overview

Peter V. Kharchenko is affiliated with Harvard University in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine. A significant portion of their work is focused on molecular biology, immunology, cancer research, oncology, and genetics.

The scientist has contributed extensively to the fields of single-cell and spatial transcriptomics, cancer genomics and diagnostics, gene expression and cancer classification, immune cells in cancer, cancer immunotherapy and biomarkers, neuroblastoma research and treatments, as well as RNA research and splicing.

Kharchenko has published in several reputable venues, with repeated contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature Communications
  • Cancer Research
  • Nature

Recent significant papers include:

  • "Comparative cellular analysis of motor cortex in human, marmoset and mouse" (2021, Nature)
  • "An atlas of healthy and injured cell states and niches in the human kidney" (2023, Nature)
  • "Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2" (2021, Genome Biology)
  • "Cell segmentation in imaging-based spatial transcriptomics" (2021, Nature Biotechnology)
  • "A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex" (2021, Nature)

Frequent co-authors collaborating closely with Kharchenko include:

  • Shenglin Mei
  • David T. Scadden
  • David B. Sykes
  • Qiwen Hu
  • Philip J. Saylor

The scientist's research reflects a broad interest in analyzing complex cellular systems using advanced transcriptomic and proteomic methods. Their work addresses important topics such as immune cell heterogeneity in cancer contexts, cell atlas construction, and comparative analysis across species and disease states.

Best Publications

  • RNA velocity of single cells

    Gioele La Manno;Gioele La Manno;Ruslan Soldatov;Amit Zeisel;Amit Zeisel;Emelie Braun;Emelie Braun

  • An integrated encyclopedia of DNA elements in the human genome

    Ian Dunham;Anshul Kundaje;Shelley F. Aldred;Patrick J. Collins

  • ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia

    Stephen G. Landt;Georgi K. Marinov;Anshul Kundaje;Pouya Kheradpour

  • Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

    Dmitry Usoskin;Alessandro Furlan;Saiful Islam;Hind Abdo

  • Bayesian approach to single-cell differential expression analysis

    Peter Vasili Kharchenko;Lev Silberstein;David Thomas Scadden

  • Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE

    Sushmita Roy;Jason Ernst;Peter V. Kharchenko;Pouya Kheradpour

  • Design and analysis of ChIP-seq experiments for DNA-binding proteins

    Peter V Kharchenko;Michael Y Tolstorukov;Michael Y Tolstorukov;Peter J Park;Peter J Park;Peter J Park

  • Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain.

    Blue B Lake;Song Chen;Brandon C Sos;Jean Fan

  • Comprehensive analysis of the chromatin landscape in Drosophila melanogaster

    Peter V. Kharchenko;Artyom A. Alekseyenko;Artyom A. Alekseyenko;Yuri B. Schwartz;Aki Minoda

  • Comparative cellular analysis of motor cortex in human, marmoset and mouse

    Trygve E. Bakken;Nikolas L. Jorstad;Qiwen Hu;Blue B. Lake

  • Landscape of Somatic Retrotransposition in Human Cancers

    Eunjung Lee;Eunjung Lee;Rebecca Iskow;Lixing Yang;Omer Gokcumen

  • Spatiotemporal structure of cell fate decisions in murine neural crest

    Ruslan Soldatov;Marketa Kaucka;Marketa Kaucka;Maria Eleni Kastriti;Maria Eleni Kastriti;Julian Petersen;Julian Petersen

  • An assessment of histone-modification antibody quality

    Thea A. Egelhofer;Aki Minoda;Aki Minoda;Sarit Klugman;Sarit Klugman;Kyungjoon Lee

  • The genomic binding sites of a noncoding RNA

    Matthew D. Simon;Charlotte I. Wang;Peter V. Kharchenko;Jason A. West

  • A Region of the Human HOXD Cluster that Confers Polycomb-Group Responsiveness

    Caroline J. Woo;Peter V. Kharchenko;Peter V. Kharchenko;Laurence Daheron;Peter J. Park;Peter J. Park

  • Comparative analysis of metazoan chromatin organization

    Joshua Wing Kei Ho;Joshua Wing Kei Ho;Youngsook L. Jung;Tao Liu;Tao Liu;Burak Han Alver

  • Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2

    Harrison Specht;Edward Emmott;Edward Emmott;Aleksandra A. Petelski;R. Gray Huffman

  • Characterizing transcriptional heterogeneity through pathway and gene set overdispersion analysis.

    Jean Fan;Neeraj Salathia;Rui Liu;Gwendolyn E Kaeser

  • Locally Disordered Methylation Forms the Basis of Intratumor Methylome Variation in Chronic Lymphocytic Leukemia

    Dan Avi Landau;Dan Avi Landau;Kendell Clement;Kendell Clement;Kendell Clement;Michael Johannes Ziller;Michael Johannes Ziller;Patrick Boyle

  • The human body at cellular resolution: the NIH Human Biomolecular Atlas Program

    Michael P. Snyder;Shin Lin

Frequent Co-Authors

Peter J. Park
Peter J. Park Harvard University
Mitzi I. Kuroda
Mitzi I. Kuroda Brigham and Women's Hospital
Catherine J. Wu
Catherine J. Wu Harvard University
David T. Scadden
David T. Scadden Harvard University
Michael Y. Tolstorukov
Michael Y. Tolstorukov Harvard University
Gary H. Karpen
Gary H. Karpen University of California, Berkeley
Jennifer R. Brown
Jennifer R. Brown Harvard University
Donna Neuberg
Donna Neuberg Harvard University
Gad Getz
Gad Getz Broad Institute
Sarah C. R. Elgin
Sarah C. R. Elgin Washington University in St. Louis

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