Hiroaki Sakurai

Overview

Best Publications

• IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain

  Hiroaki Sakurai;Hiroaki Chiba;Hidetaka Miyoshi;Takahisa Sugita

  1027
  Citations

• Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides

  H Sakurai;H Kohsaka;M F Liu;H Higashiyama

  560
  Citations

• Tumor Necrosis Factor-α-induced IKK Phosphorylation of NF-κB p65 on Serine 536 Is Mediated through the TRAF2, TRAF5, and TAK1 Signaling Pathway

  Hiroaki Sakurai;Shunsuke Suzuki;Noritaka Kawasaki;Hiroyasu Nakano;Hiroyasu Nakano

  479
  Citations

• Distinct Roles of the IκB Kinase α and β Subunits in Liberating Nuclear Factor κB (NF-κB) from IκB and in Phosphorylating the p65 Subunit of NF-κB

  Nywana Sizemore;Natalia Lerner;Nicole Dombrowski;Hiroaki Sakurai

  477
  Citations

• Targeting of TAK1 in inflammatory disorders and cancer

  Hiroaki Sakurai

  396
  Citations

• Receptor Activator of NF-κB Ligand (RANKL) Activates TAK1 Mitogen-Activated Protein Kinase Kinase Kinase through a Signaling Complex Containing RANK, TAB2, and TRAF6

  Junko Mizukami;Giichi Takaesu;Hiroyuki Akatsuka;Hiroaki Sakurai

  338
  Citations

• Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.

  Masahiro Yamamoto;Toru Okamoto;Kiyoshi Takeda;Shintaro Sato

  333
  Citations

• Role of the CXCL12/CXCR4 Axis in Peritoneal Carcinomatosis of Gastric Cancer

  Kazuo Yasumoto;Keiichi Koizumi;Atsuhiro Kawashima;Yurika Saitoh

  327
  Citations

• Functional Interactions of Transforming Growth Factor β-activated Kinase 1 with IκB Kinases to Stimulate NF-κB Activation

  Hiroaki Sakurai;Hidetaka Miyoshi;Wataru Toriumi;Takahisa Sugita

  284
  Citations

• Critical Roles of Threonine 187 Phosphorylation in Cellular Stress-induced Rapid and Transient Activation of Transforming Growth Factor-β-activated Kinase 1 (TAK1) in a Signaling Complex Containing TAK1-binding Protein TAB1 and TAB2

  Pattama Singhirunnusorn;Shunsuke Suzuki;Noritaka Kawasaki;Ikuo Saiki

  280
  Citations

• High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer.

  Shozo Hojo;Keiichi Koizumi;Koichi Tsuneyama;Yoshihisa Arita

  224
  Citations

• PKCβ regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1

  Hisaaki Shinohara;Tomoharu Yasuda;Yuichi Aiba;Hideki Sanjo

  224
  Citations

• Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells

  Kriengsak Lirdprapamongkol;Hiroaki Sakurai;Noritaka Kawasaki;Min-Kyung Choo

  222
  Citations

• Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1

  Hiroaki Sakurai;Hidetaka Miyoshi;Junko Mizukami;Takahisa Sugita

  217
  Citations

• Identification of NAP1, a Regulatory Subunit of IκB Kinase-Related Kinases That Potentiates NF-κB Signaling

  Fumitaka Fujita;Yuko Taniguchi;Takashi Kato;Yasuko Narita

  215
  Citations

• Phosphorylation of serine 276 is essential for p65 NF-κB subunit-dependent cellular responses

  Tatsuma Okazaki;Sachiko Sakon;Sachiko Sakon;Tomonari Sasazuki;Tomonari Sasazuki;Hiroaki Sakurai

  200
  Citations

• TAK1 Is Recruited to the Tumor Necrosis Factor-α (TNF-α) Receptor 1 Complex in a Receptor-interacting Protein (RIP)-dependent Manner and Cooperates with MEKK3 Leading to NF-κB Activation

  Marzenna Blonska;Prashant B. Shambharkar;Masayuki Kobayashi;Dongyu Zhang

  184
  Citations

• Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-κB activation and transformation in resistant JB6 cells

  Jing Hu;Hiroyasu Nakano;Hiroaki Sakurai;Nancy H. Colburn

  180
  Citations

• Role of CX3CL1/Fractalkine in Osteoclast Differentiation and Bone Resorption

  Keiichi Koizumi;Yurika Saitoh;Takayuki Minami;Nobuhiro Takeno

  177
  Citations

• Angiotensin II plays a pathogenic role in immune-mediated renal injury in mice.

  Yutaka Hisada;Takeshi Sugaya;Masaya Yamanouchi;Hiromi Uchida

  175
  Citations